Trombofilija, urođena ili stečena, tokom trudnoće, može dovesti do spontanog pobačaja, intrauterinog zastoja u rastu ploda koji može biti rani ili kasni, do preeklampsije i eklampsije kao i do prevremenog odlubljivanja posteljice. Tokom trudnoće, fiziološki se razvija hiperkoagulacija zbog normalnih promena u zgrušavanju krvi i fibrinolize. Ovakvo stanje u krvi trudnice ima potencijal da reaguje sa promenama u zgrušavanju krvi koje se javljaju kod trombofilije I potencijalno prouzrokovati neželjene komplikacije koje mogu ugroziti kako plod tako i trudnicu. Ispitivanja ka potencijalnoj trombofiliji, treba tražiti kod pacijantkinja kod kojih se ponavlja loš ishod trudnoće,intrauterini zastoj u rastu, fetalna smrt, preeklampsija.
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