Assessment of neutrophil-lymphocyte and platelet-lymphocyte ratio in patients with hashimoto's thyroiditis

Sanja Gašić; Milica Perić; Tamara Matić; Teodora Jorgaćević; Slađana Ilić

doi:10.5937/pramed2202015g

Abstract

INTRODUCTION: The ratio of neutrophils-lymphocytes (NLR) and platelet-lymphocytes (PLR) is a new parameter in the assessment of patients with Hashimoto's thyroiditis OBJECTIVE: The aim of this study was to investigate the effect of NLR and PLR in patients with Hashimoto's thyroiditis MATERIALS AND METHODS: In this cross-sectional study, subjects were subjected to tests of thyroid gland function, antithyroid antibodies, as well as laboratory analyzes of blood count with determination of NLR and PLR. The respondents were grouped into two groups. The first group was patients with Hashimoto's thyroiditis (HT), while the second group consisted of healthy individuals who represented the control group. RESULTS: NLR was statistically significantly higher in patients with HT compared to the control group (2.62±0.8 and 2.43±0.8, respectively; p=0.02), while PLR was higher in people with HT compared to the control group, but without statistical significance significance (169±42.5; 159±40.3; p=0.08). Among the examined patients with HT, the group with hypothyroidism showed statistically higher NLR values compared to the group of patients with euthyroid status (2.7±0.9 ; 2.31±0.7 p=0.03). Among the examined patients with HT, the group with hypothyroidism showed statistically higher PLR values compared to the group of patients with euthyroid status, as well as the group with subclinical hypothyroidism (177.8±48.2; 148.3±39.3; 155.5±42.5 p=0.04). NLR and PLR show a statistically significant positive correlation with the level of TSH, Anti TPO and TG At in the group with HT. CONCLUSION: NLR and PLR can serve as practical and valuable markers of the clinical course of the disease, but also markers of autoimmune diseases that progress with chronic inflammation.

References

Kim D. Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis. HORMONES.

Tulgar YK, Cakar S, Tulgar S. The effect of smoking on neutrophil/lymphocyte and platelet/lymphocyte ratio and platelet indices: a retrospective study. Vol. 20. 2016. p. 27460742.

Koh CH, Bhoo-Pathy N, Ng KL, Jabir RS, Tan GH, See MH, et al. Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer. Vol. 113, British Journal of Cancer. 2015. p. 150–8.

Akdag S, Akyol A, Asker M, Duz R, Gumrukcuoglu HA. Platelet-to-Lymphocyte Ratio May Predict the Severity of Calcific Aortic Stenosis. Vol. 21, Medical Science Monitor. p. 3395–400.

Liu Z, Li Y, Wang Y, Zhang H, Lian Y, Cheng X. The Neutrophil-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios Are Independently Associated With the Severity of Autoimmune Encephalitis. Vol. 13, Frontiers in Immunology.

Chao G, Zhu Y, Fang L. Correlation Between Hashimoto’s Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D. Vol. 11, Frontiers in Endocrinology.

Duntas LH. Environmental factors and autoimmune thyroiditis. Vol. 4, Nature Clinical Practice Endocrinology & Metabolism. 2008. p. 454–60.

Demirbilek H, Kandemir N, Gonc EN, Ozon A, Alikasifoglu A, Yordam N. Hashimoto’s Thyroiditis in Children and Adolescents: A Retrospective Study on Clinical, Epidemiological and Laboratory Properties of the Disease. Vol. 20, Journal of Pediatric Endocrinology and Metabolism. 2007.

Zeng Z, Wang C, Wang B, Wang N, Yang Y, Guo S, et al. Prediction of neutrophil-to-lymphocyte ratio in the diagnosis and progression of autoimmune encephalitis. Vol. 694, Neuroscience Letters. 2019. p. 129–35.

10.

Hu ZD, Sun Y, Guo J, Huang YL, Qin BD, Gao Q, et al. Red blood cell distribution width and neutrophil/lymphocyte ratio are positively correlated with disease activity in primary Sjögren’s syndrome. Vol. 47, Clinical Biochemistry. 2014. p. 287–90.

11.

Onalan E, Aslan M. Could neutrophil to lymphocyte ratio be a marker in Hashimotos thyroiditis? Journal of the Pakistan Medical Association. 2020. p. 1.

12.

Liu C, Lee J, Liu T, Chang Y, Hsu Y, Cheng S. Blood neutrophil‐to‐lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. Vol. 107, Journal of Surgical Oncology. 2013. p. 493–7.

13.

Kim JY, Park T, Jeong SH, Jeong CY, Ju YT, Lee YJ, et al. Prognostic importance of baseline neutrophil to lymphocyte ratio in patients with advanced papillary thyroid carcinomas. Vol. 46, Endocrine. 2014. p. 526–31.

14.

Hammerstad SS, Jahnsen FL, Tauriainen S, Hyöty H, Paulsen T, Norheim I, et al. Inflammation and Increased Myxovirus Resistance Protein A Expression in Thyroid Tissue in the Early Stages of Hashimoto’s Thyroiditis. Vol. 23, Thyroid. 2013. p. 334–41.

15.

Li J, Chen Q, Luo X, Hong J, Pan K, Lin X, et al. Neutrophil‐to‐Lymphocyte Ratio Positively Correlates to Age in Healthy Population. Vol. 29, Journal of Clinical Laboratory Analysis. 2015. p. 437–43.

16.

Zahorec R. Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Vol. 122, Bratislava Medical Journal. 2021. p. 474–88.

17.

Arpaci D, Gurol G, Ergenc H, Yazar H, Tocoglu A, Ciftci I, et al. A Controversial New Approach to Address Hematological Parameters in Hashimoto’s Thyroiditis. Vol. 62, Clinical Laboratory. 2016.

18.

Bilge M, Yesilova A, Adas M, Helvaci A. Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis. Vol. 127, Experimental and Clinical Endocrinology & Diabetes. 2019. p. 545–9.

19.

Onalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid Hashimoto’s thyroiditis. Vol. 91, Acta Bio Medica Atenei Parmensis. p. 310–4.

20.

Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E, et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis. Vol. 63, Revista da Associação Médica Brasileira. p. 1065–8.

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