The thyroid gland produces two major active thyroid hormones, thyroxin (T4) and triiodothyronine (T3). The production of these hormones within the thyroid is regulated by thyreotropin (thyroid-stimulating-hormone- TSH). Iodine deficiency is the most common cause of goiter and borderline hypothireoidsm word-widw. In non iodine deficient areas, however autoimmunity is the most common cause of hypothyroidism. Destructive therapy by surgery or radioiodine for thyrotoxicosis acounts for approximately one third of all cases excessive iodine (e. g. as e result of chronic ingestion of proprietary cough medicines) may also cause hi pothyreoidsm. Primary hypothireoidsm due to failure much more common than failure secondary to pituitary dysfunction, or tertiary hypothireoidsm due to hypothalamic disease. The symptom of hypothireoidsm are non-specific and may be attributed by bath patient and doctor to ageing the onset usually being insidious. Hypothireoidsm is treated with replacement T4 therapy. The author describe a 55 year-old women with diagnosis of Primary hypothireoidism. The disease had a rarely course with disorders this metabolism lipids and complications here cardiovascular system. 

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