Actual hypothesis related to development of the age-related cataract focus the photo oxidative stress as a key process of cataract genesis. It considers that damages in the lens cells, caused by sunlight and oxygen within photodynamic action of the photo oxidative stress, make essence of the cataract genesis process. Although the cataractogenes is primary a local process that flows in a local compartment, oxidative stress is often a systemic event. It relates particularly to the older age, i.e. to the ageing process itself. Even if special regulatory mechanisms of the eye provide appropriate supply of antioxidative elements on the local level, fulfilling of the eye and it's lens with antioxidative elements depends on their systemic availability and distribution. By investigation of concentrations of malondialdehyde, vitamin C, vitamin E, glutathione and albumin, and activity of cathtalase and peroxidase in serums of patients with age-related cataract, as well as with comparison of the same elements values in serums of the same age and sex distribution group of people without cataract, we found noticeable differences of the oxidative stress intensity in serums within those two investigated groups.
Tarwadi K, Agte V. Linkages of Antioxidant, Micronutrient, and Socioeconomic Status with the Degree of Oxidative Stress and Lens Opacity in Indian Cataract Patients. Nutrition. 20(3):261–7.
2.
Stringer MD, Gorog PG, Freeman A, Kakkar. Lipid Peroxides and Atherosclerosis. BMJ. 289:281–4.
3.
Varma SD, Devamenoharan PS. Morris SM: Prevention of Cataract by Nutritional and Metabolic Antioxidants. Crit Rev Food Sci Nutr. 35(1–2):111–29.
4.
Italian-American Cataract Study Group: Risk Factors for Age-Related Cortical, Nuclear, and Posterior Subcapsular Cataracts. Am J Epidemiol. 133(6):541–2.
5.
van der Pols JC: A Possible Role of Vitamin C in Age-Related Cataract. Proc Nutr Soc. 58(2):295–301.
6.
Kottler UB, Dick HB, Augustin AJ. Is a Cataract Avoidable? Current Status with Special Emphasis on the Pathophysiology of Oxidative Lens Damage, Nutritional Factors, and the AREDS Study. Ophthalmol. 100(3):190–6.
7.
Age-Related Eye Disease Study Group: A Randomized, Placebo-Controlled Clinical Trial of High-Dose Supplement.
8.
Age-Related Eye Disease Study Group: A Randomized, Placebo-Controlled Clinical Trial of High-Dose Supplementation with Vitamins C, E, and Beta Carotene for Age-Related Cataract and Vision Loss. AREDS Report. 119(9):1439–52.
9.
Schalch W, Chylack LT. Antioxidant Micronutrients and Cataract: Review and Comparison of the AREDS and REACT Cataract Studies. Ophthalmologe. 100(3):181–9.
10.
Repka T, Hebbel RP. Hydroxyl Radical Formation by Sickle Erythrocyte Membranes: Role of Pathologic Iron Deposits and Cytoplasmic Reducing Agents. Blood. 78(10):2753–8.
11.
Taylor A, Hobbs M. Assessment of Nutritional Influences on Risk for Cataract. Nutrition. 17(10):845–57.
12.
Taylor A, Jahngen-Hodge J, Smith DE. Dietary Restriction Delays Cataract and Reduces Ascorbate Levels in Emory Mice. Exp Eye Res. 61(1):55–62.
13.
LT C. Ageing Changes in Crystalline Lens and Zonules. In: Albert/Jakobiec Basic Sciences Principles and Practice of Ophthalmology. p. 1107–12.
14.
Mohan M, Sperduto RD, Angra SK. India-US Case-Control Study of Age-Related Cataract. Arch Ophthalmol. 107:670–6.
15.
Kawai K, Yoh M, Hayashi T, Imai H. Effect of Diabetic Retinopathy on Redox State of Aqueous Humour and Serum Albumin in Patients with Senile Cataract. Tokai J Exp Clin Med. 26(3):93–9.
16.
Obara Y. The Oxidative Stress in Cataract Formation. Nippon Ganka Gakkai Zasshi. 99(12):1303–41.
17.
Frei B, Stocker R, Ames BN. Antioxidant Defenses and Lipid Peroxidation in Human Blood Plasma. Proc Natl Acad Sci USA. 85:9748–52.
18.
Reiss GR, Werness RP, Zollman PE, Brubaker RF. Ascorbic Acid Levels in the Aqueous Humour of Nocturnal and Diurnal Mammals. Arch Ophthalmol. 104:753–5.
19.
Malik A, Kojima M, Sasaki K. Morphological and Biochemical Changes in Lens of Guinea Pigs After Vitamin C Deficient Diet and UV-B Radiation. Ophthalmic Res. 27(4):189–96.
20.
Leske MC, LT C, Wu SJ. The Lens Opacities Case-Control Study: Risk Factors for Cataract. Arch Ophthalmol. 109:244–51.
21.
Jackues PF, LT C, McGandy RB, Hartz SC. Antioxidant Status in Persons with and Without Senile Cataract. Arch Ophthalmol. 106:337–40.
22.
Metelitsyna IP. Metabolic Disturbances in Blood from Patients with Senile Cataracts Accompanied by Somatic Diseases. Ukr Biokhim Zh. 70(2):110–5.
23.
Pavlović D, Trajković G, Kovačević J. Statistika za Medicinare.
24.
Petz B. Osnovne Statističke Metode za Nematematičare.
25.
Ledwozyw A, Michalak B, Stepien A, Kadziolka A. The Relationship Between Plasma Triglycerides, Cholesterol, Total Lipids, and Lipid Peroxidation Products During Human Atherosclerosis. Clin Chim Acta. 155:275–84.
26.
N MS. Klinička Enzimologija.
27.
Koroljuk MA, Ivanova LI, Maiorova JG, Tokarev VE. Metod Predelenia Aktivnosti Katalazi. Lab Delo. 1:16–9.
28.
Dacie JV. Lewis SM: Estimation of Reduced Glutathione (GSH.
29.
Štraus B. Medicinska Biokemija.
30.
McCorwick DB. Vitamins. In: Tetz NW Textbook of Clinical Chemistry.
31.
Christen WG, Glynn RJ. Hennekens CH: Antioxidants and Age-Related Eye Diseases: Current and Future Perspectives. Ann Epidemiol. 6(1):60–6.
32.
Fecondo JV, Augusteyn RC. Superoxide Dismutase, Catalase, and Glutathione Peroxidase in the Human Cataractous Lens. Exp Eye Res. 36:15–8.
33.
Kwan M, Nikikoski J, Hunt TK. In Vivo Measurement of Oxygen Tension in the Cornea, Aqueous Humour, and Anterior Lens of the Open Eye. Invest Ophthalmol Vis Sci. 11:108–11.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
