Actual hypothesis related to development of the age-related cataract focus the photo oxidative stress as a key process of cataract genesis. It considers that damages in the lens cells, caused by sunlight and oxygen within photodynamic action of the photo oxidative stress, make essence of the cataract genesis process. Although the cataractogenes is primary a local process that flows in a local compartment, oxidative stress is often a systemic event. It relates particularly to the older age, i.e. to the ageing process itself. Even if special regulatory mechanisms of the eye provide appropriate supply of antioxidative elements on the local level, fulfilling of the eye and it's lens with antioxidative elements depends on their systemic availability and distribution. By investigation of concentrations of malondialdehyde, vitamin C, vitamin E, glutathione and albumin, and activity of cathtalase and peroxidase in serums of patients with age-related cataract, as well as with comparison of the same elements values in serums of the same age and sex distribution group of people without cataract, we found noticeable differences of the oxidative stress intensity in serums within those two investigated groups.

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