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HISTOCHEMICAL LOCALISATION AND ACTIVITY OF DPP IV IN ANTIGEN STIMULATED TONSILLA

S. Savić ,
S. Savić

Institute of Histology and Embryology, Medical faculty , Priština, Kosovska Mitrovica

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S. Savić ,
S. Savić

Institute of Histology and Embryology, Medical faculty , Priština, Kosovska Mitrovica

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V. Avramović ,
V. Avramović

Institute of Histology and Embryology, Medical faculty , Niš , Serbia

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V. Vlahović
V. Vlahović

Institute of Nephrology and Hemodialisis, Clinical center , Niš , Serbia

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Published: 01.01.2004.

Volume 32, Issue 1 (2004)

pp. 11-18;

https://doi.org/10.70949/pramed200401061S

Abstract

Dipeptidyl peptidase IV is ecto-enzyme which is present on the cell surface of large number of cells and particularly of T-lymphocytes. It takes part in immune reactions and regulation of immune response, while antigen stimulation of cells increases percentage of expression of DPPIV on their cell surfaces. Since the immune response is different for chronic tonsillar disease of tonsilla palatine, idiopathic tonsillar hyperplasia ITH and recurrent tonsillitis RT, and considering the fact that DPPIV takes part in activation of T and B-lymphocytes stimulated by antigen, we presume that different activities of DPPIVexist in tonsillis and blood of persons diseased of different types of chronic tonsillitis, ITH and RT. The main goals of research are determination of activities of DPPIV on lymphocytes of tonsillas and serum of persons diseased of ITH and RT as well as histochemical and immunohistochemical determination of DPP IV localisation on lymphocytes of examed tonsillas. Two groups of patients are included: nineteen persons with ITH and thirteen persons with RT, while the control group was contained of thirty nine persons with diagnosis systematic lupus erythematosus (SLE) and fiftteen health persons. The research was done on 32 tonsillas created by tonsillectomia of persons with ITH and RT and 86 blood samples of all 86 persons. The results of research show histochemical localisation of enzyme activity of DPPIVin T-dependent zones of tonsilla and it is originating from activated T-lymphocytes. The enzyme activity of DPP IV on tonsillar lymphocytesis is higher in case of IHT compared with RT. By this research we conclude that deifferent activity of DPPIV on tonsillar lymphocytes for ITH and RTpresumes the difference of immuno response of tonsillas during these tonsillar diseases.

Keywords

Dipeptidyl peptidase IV (DPPIV),

T-limphocyte; tonsilla palatina,

idiopathic tonsillar hyperplasia (ITH),

re current tonsillitis (RT)

References

1.
Kähne T, Neubert K, Faust J, Ansorge S. Early phosphorylation events induced by DPPIV/CD26-specific inhibitors. Cell Immunol. 189:60–6.
2.
Agren K, Andersson U, Litton M, Funa K, Nordlander B, Andersson J. The production of immunoregulatory cytokines is localized to the extrafollicular area of human tonsils. Acta Otolaryngol. 116:477–85.
3.
Brandtzaeg P. Immunopathological alteration in tonsillar disease. Acta Otolaryngol (Stockh. Suppl. 454:64–9.
4.
Resta R, Thompson LF. T cell signaling through CD73. Cell Signal. 9:131–9.
5.
Mentlein R, Heymann E, Scholz W, Feler AC, Flad HD. Dipeptidyl peptidase IV as a new surface marker for a subpopulation of human T-lymphocytes. Cellular Immunology. 89:11–9.
6.
Fleischer B. CD26: a surface protease involved in T-cell activation. Immunology Today. 15(4):180–4.
7.
Tanaka T, Camerini D, Seed B. Cloning and functional expression of the T cell activation antigen CD26. J Immunol. 149:481–6.
8.
Durinx C, Neels H, Auwera JC, Naelaerts K, Scharpe S, Meester I. Reference values for plasma dipeptidyl-peptidase IV activity and their association with other laboratory parameters. Clin Chem Lab Med. 39(2):155–9.
9.
Martin M, Huguet J, Centelles JJ, Franco R. Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex - possible role of adenosine deaminase as costimulatory molecule. J Immunol. 155:4630–43.
10.
Meester I, G V, L K. Binding of adenosine deaminase to the lymphocyte surface via CD26. Eur J Immunol. 24:566–70.
11.
Avramović V. Topografska distribucija i kvantifikacija imunoglobin-produkujućih ćelija kod antigen stimulisane tonzile. Doktorska disertacija.
12.
Hegen M, Kameoka J, Dong RP, Schlossman SF, Morimoto C. Cross-linking of CD26 by antibody induces tyrosine phosphorylation and activation of mitogen-activated protein kinase. Immunology. 90:257–64.
13.
Kähne T, Lemdeckel U, Wrenger S, Neubert K, Ansorge S, Reinhold D. Dipeptidyl peptidase IV: A cell surface peptidase involved in regulating T cell growth. Int J Mol Med. 3:199–211.
14.
Bühling F, Junker U, Reinhold D, Neubert K, Jager L, Ansorge S. Functional role of CD26 on human B lymphocytes. Immunol Lett. 45:47–51.
15.
Cordero OJ, Salgado EJ, Vinuela LE, Nogueira M. Interleukin-12 enhances CD26 expression and dipeptidyl peptidase IV function on human activated lymphocytes. Immunobiology. 197:522–33.
16.
Gorrell MD, Wickson J, McCaughan GW. Expression of the rat CD26 antigen (dipeptidyl peptidase IV) on subpopulations of rat lymphocytes. Cell Immunol. 134:205–15.
17.
Fleischer B, Sturm E, De-Vries JE, Spits H. Triggering of cytotoxic T lymphocytes and NK cell via the Tp 103 pathway is dependent on the expression of the T cell receptor/CD3 complex. J Immunol. 141:1103–7.
18.
Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept. 85(1):9–24.
19.
Gorrell MD, Gysbers V, McCaughan GW. CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand J Immunol. 54(3):249–64.
20.
Bednarczyk JL, Carroll SM, Marin C, McIntyre BW. Triggering of the proteinase dipeptidyl peptidase IV (CD26) amplifies human T lymphocyte proliferation. J Cell Biochem. 46:206–18.

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