Oral health is an integral part of the general health of humans and significantly affect the quality of life. Dental caries is today the most widespread disease of our civilization, which if untreated leads to tooth loss. It is significant to note that studies show the possibility of successful prevention of diseases of the oral cavity. Traditionally, there has always been lower economic and educational level of the population in rural areas, and also a lower availability of dental services. Possible reasons for this include the lack of pediatric dental offices in schools in rural areas, the greater the distance of the dentist, the lack of properly organized school dental care, lack of knowledge about the importance of oral health by their parents as role models and unfavorable socio-economic status. The aim of this study was to examine the level of awareness and habits of children and parents toward oral hygiene and bad habits in the Serbian enclaves in Kosovo and Metohija and to compare them with children who live in urban areas in Kosovska Mitrovica. The study included 160 elementary school students in the area of Kosovska Mitrovica (urban area) and the Serbian enclaves on Kosovo and Metohia (rural area) which included elementary school students from Sirinić District, the Kosovo Morava, the central Kosovo, villages of Suvo Grlo and Banja in municipality Istok. By examining the frequency of tooth brushing we found that 32 (40%) of children in enclaves brush their teeth once a day, 40 (50%) two times a day, and only 8 (5%) of them maintain hygiene teeth 3 times a day. Boys who wash their teeth three times a day were 12.5% and 37.5% of girls. The children from the enclave more often come to the dentist when they have an appointment (33:8), while children from Kosovska Mitrovica more often come to the quarterly control (21:4). An interesting fact is that 15.33% of children from urban areas cited as a source of oral health information from the Internet and Android application for mobile phone or tablet. The difficult security situation, limited freedom of movement, the poorly developed dental services, poor health education and promotion of oral health of the population of Serbian enclaves, the reason for the weaker informing children and parents about preventive dental measures. It is necessary to mobilize all sectors of society on joint actions aimed at the promotion of oral health.

Collagen is a major constituent of the gingival extracellular matrix, which crucially affects the histoarchitecture of the gingival tissue. Collagen type I dominates the gingival tissue, while type II, III and IV are present to a lesser extent. Changes in distribution and density occur in the inflamed gingiva. The aim of the study was to examine the organization and density of the collagen in healthy and inflamed gingiva. The material for the study consisted of the gingival biopsies performed in 96 patients aged from 13 to 70 years. The gingival specimens were classified into 4 groups: healthy gingiva, gingivitis, moderate periodontal disease and severe periodontal disease. The samples of the gingival tissues were stained by the method of Van Gieson’s Stain, while the VD of the collagen was measured bz the use of multipurpose testing system M42. In healthy gingival collagen are thick and receptive to color. In gingivitis collagen is mostly preserved structure, but reduced volume; in the periodontitis collagen bundles are reduced, short, thin, disorganized, often fragmented and less susceptibility to color. In healthy gingiva collagen fibers occupy 58.6 ± 5.1% of the volume of lamina propria; in gingivitis significantly lower (44.2 ± 6.2%); in moderate periodontitis 32.7 ± 8.5% and in the progressed periodontitis only 28.7 ± 9.7%. Based on our results, we concluded that in periodontal disease occurs collagenolysis. Quantitative evaluation of gingival collagen volume density may reflect the clinical severity of periodontal disease.

Hypertension represents one of the most significant preventable causes of death worldwide, and accordingly the target group for its prevention and early detection primarily refers to young population. Assessment of prevalence of selected risk factors for the development of hypertension among students, and determination of the existence of differences between genders, defined age groups and included faculties. A cross-sectional study was carried out during 2013., at Faculties of Medical Sciences, University of Belgrade. Respondents completed an questionnaire specially designed for the purpose of this study. Categorical data were analyzed using statistical chi-square test of independence. The study included 600 respondents, mainly female (61.2%), with the mean age of 53.1 ± 17.4 years. More than third of the participants (38,6%) reported the genetic predisposition to development of hypertension. Recorded modifiable risk factors were overweight (22,33%), regular extra salt intake (86,3%) and smoking (32,8%). The results of the study indicate presence of reversible risk factors in the observed population. Designing educational programs on chronic diseases during graduate studies is necessary to keep hypertension from developing at older age and mitigate the number of existing risk factors development.

Tests have shown that adipose tissue is very important in the production of chemical substances that have a major impact on atherosclerosis. The basic fat cells adiposity is very active in bio secretion hormones and other substances. Adiposities secrete chemical substances such as leptin, resistin, adiponectin, and others who participate in metabolic processes. One of the most important adipocytokine affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. So our aim was to determine the value of the concentration of adiponectin and resistin on patient with myocardial heart attack and determine their correlation with the control group of healthy subjects. In this study were included 68 subjects, 40 with myocardial heart attacks and 28 control groups of normal healthy. In the group with myocardial 78.6% of respondents were male and 21.4% female. Tests have shown that the concentration of adiponectin in the group with myocardial heart attack was significantly lower than the control group (4.94 to 6.74, p=0.043, p<0.05. In the same study group average value of resistin was significantly higher than in the control group (15.73 to 7.88, p=0.001, p<0.01) (Student's t-test, p = 0.581, p> 0.05). All this indicates that in patients with myocardial heart attack there is a decline in the concentration of adiponectin, which has cardio protective effect. The increase in resistin in myocardial heart attack in directly related to the appearance of athermanous plaques in the coronary blood vessels and has a bad prognostic significance.

Patient fear from dental intervention is the most common cause of permanent disposal of the visits to the dentist by the patient , and there arise some magic circle in which symptoms of disease becomes more intensive , which proportionally increase the already present fear and further delay the visits to the dentist . The ultimate outcome is compromised oral health with early loss of teeth and chewing function , speech , etc. The aim of work is to determine the frequency of fear from dental intervention , occurrence of pain during certain phases of tooth extraction , its intensity , and justified fear of the patient from the most common oral surgery . The study includes 96 patients , aged 16-45 years , of whom 55 were male and 41 were female . For the assessment of fear of dental intervention was used Korah modified anxiety scale consisted of four questions ,in which every question has an answer and they are scored on a five point Likert scale . To determine the prevalence of pain in various stages of extraction there was used interview about the pain made up of three questions , and the sample consisted of patients divided by Kore scale into high and very high anxiety person. People who have positively responded to the questionnaire, the pain was further determined with visual analogue scale. For statistical analysis we used hi square test at a significance of level p<0,05. Modified Kore scale in a group of very highly anxious individuals were classified as 8 (7.68%), highly anxious individuals 15 (14.4%), moderately anxious individuals 31 (29.76%)and in the group of people without anxiety 42 patients (40, 32%).From a total of 23 patients identified as high and very high anxiety , only three (14%) felt the pain during the observation and characterized as a mild by using visual analogue scale as mild. By using Hi-square test (p<0,05) there were significant differences in responses( x²=12,6>5,92) . Five patients (22,74%) felt the pain during anesthesia where was found statistically significant differences in responses (X ²=7.34> 5.91) . Two patients (8.7%) registered the pain during tooth extraction and all the pain was characterized as mild to moderate. There was no statistically significant difference using the Hi square in the responses (x²=15,69>5,91 za p<0,05). The frequency of dental anxiety in our sample was very high in comparison with similar studies in the west of Europe, and the possible cause among other things, can be considered as a lower level of education of the population on which we must work. The emergence of real pain in high and very high anxiety patients during tooth extraction is very small, which indicate the unjustified fear of this type of intervention .

Due to the extension of life expectancy, the number of elderly people increases, and thus the number of disease and injuries of the locomotor system, especially the hip joint. One of the persistent trend is an increasing trend in the number of patients with coxarthrosis and implanted total hip endoprosthesis. One of the postoperative complications that occurred after implantation a total hip endoprosthesis is heterotopic ossification (HO). HO is the most common complication that occurs after the implantation a total hip endoprosthesis with recorded cases in the range of 9-90%. HO are insufficiently understood phenomenon, which is characterized by the formation of bone in periarticular tissues. We prospectively followed patients who implanted total hip endoprostheses in the department of orthopedics ZC in Kos. Mitrovica in 2008. and 2009. year. We examined the influence of physical agents on the prevention of HO near the hip joint. In these patients the treatment was carried out kinesiotherapeutic at the Center for Rehabilitation Health Center Kosovska Mitrovica, as well as pulse therapy low frequency magnetic field frequency of 30 Hz, 30 minutes, 8 mT intensity and 15 minutes interferential current, 0-100 Hz frequency. All patients were on the rehabilitation of one month (20 days). Based on this research we confirmed the assumption that the use of low frequency pulsed magnetic fields, interference currents and kinesitherapy prevents HO in patients after implantation of total endoprosthesis of the hip joint.

The aim is to determine pathological -ulcero-erosive changes in the gastroduodenal mucosa (erosions, ulcers, ulcers, ulcer complications, subepithelial hemorrhage, etc.) resulting from the adverse effects of salicylates /ACK/ corticosteroid, imunoodulatora which was prescribed in the treatment of rheumatoid arthritis (RA). The test was performed on 50 patients diagnosed with RA who were on the two-year continuous therapy. When respondents were done gastroscopy and pathological macroscopic changes resulting from the gastroduodenal mucosa as a result of adverse effects of administered drugs verified. After two years of preparations ACK controlled therapy, corticosteroids, imunomodula- sector on mucosa gastroduodenal erosions were found in 81.5% of patients, gastric ulcer in 33%, duodenal ulcer with 18.5% of patients and bleeding in 44.4%.

Leukoaraiosis is a change in brain white matter with characteristic manifestation in MR and CT head scans. Common leukoaraiosis risk factors include aging and arterial hypertension. A quarter of symptomatic ischemic infarcts belongs to small blood vessel disease group and could be presented as lacunar infarcts. These two crucial pathophysiological mechanisms are in the root of cognitive dysfunction related to small blood vessel disease. 60 lacunar infarct patients were examined and parameters for groups with and without leukoaraiosis were determined. It was found that leukoaraiosis incidence was highest in the group of women older than 70. Neurological assessment was scored on NIH-NINDS scale, functional status was scored with Barthelo index, and cognitive status was determined using Mini Mental State Examination (MMSE) and Alzheimer Disease Assessment Scale Late (ADAS-L). Correlation analysis of these parameters on significance level of *p<0.05, **p<0.01, suggests decrease in neurological status and cognitive performance.

Delivery before 37th week of gestation is defined as preterm, independently of body mass of babies, according to the World Health Organization. Premature birth is the current problem in the world due to the high risk of neonatal morbidity and mortality and incompletely clear etiology. In our country the frequency of preterm delivery is 6%. We have retrospectively analyzed early deliveries in Health Center Kosovska Mitrovica in the period from 2009 to 2013. In this five-year period, there were totaly 3398 deliveries, of which 148 or 4.35 % were preterm delivery. The aim of this study was to investigate the incidence of premature birth in the five-year period in relation to: the total number of births in a given period, the age of the patients, the manner of completion of delivery, gestational week of pregnancy, parity and the most common causes that led to the PTP. In the analysis we have included the body weight and Apgar score of premature infants. We have used protocols of births, maternal history of disease, neonatal protocols and lists of newborns. Most of them were multiparas (41.2 %),56.7 % of pregnant women were aged of 21-30 years and pregnancy in 79.9 % of cases ended with 33 to 37 ng. Vaginal deliveries were completed in 84.4% of premature births, and caesarean in 15.6%. Twin pregnancies with preterm deliveries were represented in 10.2%. The most common weight of premature infants ranged from 2000 to 2500 grams (48.6 %). The most common causes that led to the PTP were PPROM (22.9 %), unknown causes (27. 1 %), multiple pregnancy (18.2 %), genital infection (8.7 %), cervical incompetence (6.7 %), IUGR (5.4%), PIH (4.2%), placental abruption and placenta previa (2.1 %) and other (4.7%) .

The number of elderly with chronic kidney disease (CKD) is constantly increasing worldwide, and irregular screening of CKD leads to disease discovering usually in advanced stages. The aim of the study was to examine the presence of CKD biomarkers in the elderly primary care patients, and to analyze whether the presence of diabetes and hypertension in elderly increases the risk for microalbuminuria and reduction of glomerular filtration rate (GFR). Cross-sectional study included 90 patients older than 65 years of age who are registered in the Family medicine teaching centre of Health centre Bijeljina. Patients were divided into three groups: first consisted of 30 patients who had neither hypertension nor diabetes nor other chronic disease, second of 30 patients with type 2 diabetes mellitus and third of 30 patients with arterial hypertension. Data on patients were obtained by interview, analysis of medical records and physical examinations. Serum and urine creatinine, proteinuria, microalbuminuria (MAU, turbidimetry), and urinary sediment were analyzed. Biomarkers of chronic kidney disease (GFR <60 mL / min / 1.73m2, proteinuria and mikroalbuminurija<MAU) were found in 20 (22.2%) patients. Among them, 14 had normal GFR and MAU (12) or MAU and proteinuria (2), whereas 6 had GFR <60 mL / min / 1.73m2 of which 3 had proteinuria and / or MAU. The group with diabetes had significantly more MAU compared to the other two groups, while the groups with diabetes and hypertension had slightly more proteinuria and erythrocyturia than control group. Hypertension and diabetes in the elderly may result in development of CKD biomarkers, so prevention and regular screening of CKD in the patients with these two diseases are necessary.

Among the many antibiotics that treat infections of the respiratory system, the most common and with a large role are penicillins, cephalosporins, and macrolides. Acute otitis media is rapidly formed otitis media, with the duration of the inflammatory process to 3 weeks. As a rule, there is a nasal-pharyngeal route, and causes are viruses, bacteria and / or a viral / bacterial coinfection. To determine the effectiveness of amoxicillin, amoxicillin with clavulanate, ceftriaxone and azithromycin in children aged 0 to 14 years, depending on the number of repeat episodes. 120 patients with acute inflammation of the middle ear, treated in the cabinet of Otorhinolaryngology of Health Center of Gracanica. Diagnosis of the patients was placed and confirmed on the basis of physical examination, laboratory and microbiological analysis and tympanometry findings. 120 children aged 0-14 years. 52 (43.33%) male and 68 (56.67%) female. In 37 (30.83%) an episode of OMA, in 41 (34.86%) two episodes, in 29 (24.16%) three, in 13 (10.83%) cases more than three episodes in the past year. In 23 (19.16%) two epizide acute inflammation shorter than two months, in 11 (9.16%) children 3 episodes in 6 months, and in 13 (10.83%) children four episodes OMA for a period of one year . Causes: Streptococcus pneumoniae (37.64%), Haemophilus inphluenzae (14.11%), Moraxella catarrhalis (12.94%) and Pseudomonas (12.94%), Staphylococcus aureus (4.70%), Escherichia coli (4.70%) and Streptococcus pyogenes (3.52%). Amoxicillin (90 mg / kg bw) and amoxicillin + clavulanate (90 mg / kg bw), azithromycin (5-10 mg / kg bw), ceftriaxone (50mg / kg). Based on our research, we came to the data that is generally consistent with the WHO recommendations for the treatment of OMA in children.

Diabetes mellitus is one of the most common non-communicable chronic diseases, which is the combined action of genetic factors, environmental factors and lifestyle. Specific conditions occur in the oral cavity in the course of diabetes that cause changes in all oral tissues with different symptoms and signs. Increased salivary glucose level is followed by increased accumulation of dental plaque and decreased resistance to noxious agents. The most common oral manifestations in diabetic patients include higher prevalence of periodontal desease, burning mouth syndrome, disruption in salivary flow, opportunistic infections, higher prevalence of denture stomatitis, oral lichen planus, fissured tongue, angular cheilitis etc. Dental interventions in patients with well-controlled diabetes are not different from those applied to nondiabetic patients. Regular monitoring of these patients is required because of the complications that can occur.

Modern aspects of social development brings new concerns that contribute to obesity, as a direct result of the overall abundance. Almost that there is declarative consistent view that obesity, according to its frequency, a global epidemic of the new millennium and that is because of the effect on the overall health of the necessary complementary multidisciplinary approach, because its prevention can prevent and significantly reduce the mortality rate. Technological development, automation in the food production, reduced participation of manual labor and a sedentary lifestyle, obesity causes an increase not only in highly industrialized, but in the less developed countries. Obesity is a direct temptations of modern civilization and a major challenge for a community where food is plentiful. This fact increases the responsibility of each individual and placed before him the obligation to recognize the causes of obesity, so that, by changing their behavior, could reduce the burden involved with obesity.

Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine has been commonly implicated in SJS. We report a case of SJS-TEN overlap syndrome developing in patient who was prescribed carbamazeine after epileptic attack during radiotherapy for the purpose of treatment Glioblastoma multiforme, patients underlying disease, whose symptomatology deteriorated patients condition.

Meniscus injuries occupy an important place among damages to the knee joint and are crucially important for athlets. Arthroscopy is a method of choice in both diagnostic as well as therapeutic treatment. After the intervention, it is necessary to start physical tretmeant as soon as possible. The study presents the treatment of 14 year old female patient, who started physical therapy five days after the removal of part of the lateral meniscus. Procedures involved electrical and kinesy therapy. Within the kinesy treatment static contractions were included, lymphatic drainage, and also passive exercises in order to increase range of motion. In the end, exercises against resistance were conducted to strengthen the musculature. After one month of therapy the treatment was completed, and patient was advised to continue strengthening the musculature at home. During the last examination the absence of swelling was noted, with painful sensitivity and limited motion in the knee. The MMT score for qvadriceps femoris was 4. The patient was advised to start with the lighter recreative activities. Arthroscopic meniscotomy is relatively rare intervention with adolescents, which was the motive for displaying this case. Applying early rehabilitation is fully exploited regenerative potential of this age and the optimal time for patients to return completely to usual activities.

One of the best-studied responses of cognitive evoked potentials is a so-called “P300”, the late positive wave complex that occurs about 300-500 ms after the stimulus. It is obtained when the subject’s attention is focused on a signal that is rare, especially if the signal has a motivational or emotional meaning. In the study of P300 potential, we followed the variations of potential amplitude and latency, so the objective was to examine whether there is a difference in Fz and Cz amplitudes of auditory induced cognitive evoked P300 potential depending on the performance of oddball tasks, both in male and female subjects. The study included 60 subjects (30 female respondents and 30 male respondents). P300 potential is induced by the auditory "oddball" paradigm with 80% of non-target and 20% of target stimuli that are presented to the patient through headphones. The target tones are high tones of 2000 Hz. The standard, 1000 Hz tones the respondent should ignore but when he hears the target tones the respondent should press the button on the special handle. The value of Fz and Cz amplitudes both in male and female subjects obtained in the classical "oddball" paradigm when the subject reacted to the signal by pressing the key with the dominant (right) arm were statistically significantly lower (p>0,05) than the values of Fz and Cz amplitudes obtained when the key was pressed by the non-dominant hand. Based on this experiment it can be concluded that both in male and female subjects the performance of oddball tasks does not affect the amplitude of P300 cognitive evoked potentials.

Disturbances of thyroid function are often accompanied by cognitive and affective disorders. Assessment of cognitive status in the patients with subclinical hypothyroidism represents a possibility for early diagnostics of cognitive impairment and timely introduction of necessary pharmacotherapy treatment. The aim of this study was to quantify whether there are P3 event related potential (ERP) deviations as electrophysiological markers of cognitive activity in patients with subclinical hypothyroidism. P300 potentials were examined in thirty patients with subclinical hypothyroidism and in 30 healthy subjects of the control group. P300 was recorded using the classic auditory oddball paradigm, with 20% of target and 80% of non-target stimuli. The results analysis showed a significantly longer latency P300 and reduced amplitude P300 in subjects with subclinical hypothyroidism compared to euthyroid subjects. There is also a statistically significant negative correlation between the results of a mini mental state examination and the P300 latency at Fz electrode (r= -0.47, p <0.01) and Cz electrode (r= -0.43, p =0.017). P300 ERP is important in the evaluation of patients with subclinical hypothyroidism, due to the sensitivity in the detection cognitive disorders.

The belief in the inability of neurogenesis, that is the inability to create new neurons after embryonic and early postnatal development of the central nervous system, was rejected in the mid-nineties, when the existence of neurogenesis in restricted areas of CNS adult mammals, including humans, was discovered.Transplantation of stem cells or their derivatives into respective tissues or organs is considered as one of the most promising remedies for many incurable diseases.In this review, we summarized current knowledge and present and future perspectives andchallenges regarding stem cells treatment for Parkinson's and Alzheimer's disease, as the most common age-related neurodegenerative diseases.