The number of elderly with chronic kidney disease (CKD) is constantly increasing worldwide, and irregular screening of CKD leads to disease discovering usually in advanced stages. The aim of the study was to examine the presence of CKD biomarkers in the elderly primary care patients, and to analyze whether the presence of diabetes and hypertension in elderly increases the risk for microalbuminuria and reduction of glomerular filtration rate (GFR). Cross-sectional study included 90 patients older than 65 years of age who are registered in the Family medicine teaching centre of Health centre Bijeljina. Patients were divided into three groups: first consisted of 30 patients who had neither hypertension nor diabetes nor other chronic disease, second of 30 patients with type 2 diabetes mellitus and third of 30 patients with arterial hypertension. Data on patients were obtained by interview, analysis of medical records and physical examinations. Serum and urine creatinine, proteinuria, microalbuminuria (MAU, turbidimetry), and urinary sediment were analyzed. Biomarkers of chronic kidney disease (GFR <60 mL / min / 1.73m2, proteinuria and mikroalbuminurija<MAU) were found in 20 (22.2%) patients. Among them, 14 had normal GFR and MAU (12) or MAU and proteinuria (2), whereas 6 had GFR <60 mL / min / 1.73m2 of which 3 had proteinuria and / or MAU. The group with diabetes had significantly more MAU compared to the other two groups, while the groups with diabetes and hypertension had slightly more proteinuria and erythrocyturia than control group. Hypertension and diabetes in the elderly may result in development of CKD biomarkers, so prevention and regular screening of CKD in the patients with these two diseases are necessary.
Engberg H, Oksuzyan A, Jeune B. Centenarians -a useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905. Aging Cell. 2009;270–6.
2.
2012;
3.
Registry EE. Academic Medical Center, Department of Medical Informatics. 2011;
4.
Stevens L, Viswanathan G, Weiner D. Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance. Adv Chronic Kidney Dis. 2010;(4):293–301.
K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;(Suppl 1):1-S266.
8.
Chadban S, Briganti E, Kerr P. Prevalence of kidney damage in Australian adults: TheAusDiab Kidney Study. J Am Soc Nephrol. 2003;
9.
Standards of medical care in diabetes. Diabetes Care. 2009;(Suppl 1):13-S61.
10.
Grahami, Atar D, Borch-Johnsen K. European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil. 2007;(Suppl 2):1–40.
11.
Nielenmmj, Schellevis F, Verheij R. Prevention of chronic kidney disease in primary care] in Dutch. 2006;
12.
Levey A, Bosch J, Lewis J, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;461–70.
13.
Miller W. Estimating glomerular filtration rate. Clin Chem Lab Med. 2009;1017–9.
14.
Bačak-Kocman I. Transpantacija bubrega kod starih osoba-važnost obilježja darivatelja i primatelja. Acta Med Croatica. 2012;203–6.
15.
Zavod za zaštitu zdravlja Republike Srpske. Zdravstveno stanje stanovništva Republike Srpske. 2010;
16.
Coresh J, Selvin E, Stevens L, Manzi J, Kusek J, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;2038–47.
17.
Chen W, Wang C, H, Liu X, Mao Q, H. Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant. 2009;1205–21.
18.
Ležaić V, Dimković N, Perunićić G, Bukvić D, Bajčetić S, Pavlović J, et al. Monografije Akademije medicinskih nauka SLD. 2010;129–48.
19.
Zucchelli P. Hypertension and atherosclerotic renal artery stenosis: Diagnostic Approach. J Am Soc Nephrol. 2002;184-S186.
20.
Ležaić V, Bajčetić S, Peruničić-Peković G, Bukvić D, Dimković N, Đukanović D. Screening of Elderly for Chronic Kidney Disease. Kidney Blood Press Res. 2012;497–503.
21.
Singh N, Ingle G, Saini V. Prevalence of low glomerular filtration rate, proteinuria and associated risk factors in North India using Cockcroft-Gault and modification of diet in renal disease equation: An observational, cross-sectional study. BMC Nephrol. 2009;4.
22.
Kim S, Lim C, Han D. The prevalence of chronic kidney disease (CKD) and the associated factors to CKD in urban Korea: A population-based cross-sectional epidemiologic study. J Korean Med Sci. 2009;
23.
Król E, Rutkowski B, Czarniak P. Early detection of chronic kidney disease: Results of the PolNef study. Am J Nephrol. 2009;(3):264–73.
24.
Heidland A, Bahner U, Deetjen A. Mass screening for early detection of renal disease: Benefits and limitations of selftesting for proteinuria. J Nephrol. 2009;249–54.
25.
Brown W, Peters R, Ohmit S. Early detection of kidney disease in community settings: The Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2003;22–35.
26.
Vassalotti J, Li S, Chen SC, Collins A. Screening populations at increased risk of CKD: The Kidney Early Evaluation Program (KEEP) and the public health problem. Am J Kidney Dis. 2009;(S3):107-S114.
27.
Obrador G, García-García G, Villa A. Prevalence of chronic kidney disease in the Kidney Early Evaluation Program (KEEP) México and comparison with KEEP US. Kidney Int Suppl. 2010;(116):2-S8.
28.
Takahashi S, Okada K, Yanai M. The Kidney Early evaluation Program (KEEP) of Japan results from the initial screening period. Kidney Int. 2010;17-S23.
29.
Middleton R, Foley R, Hegarty J. The unrecognized prevalence of chronic kidney disease in diabetes. Nephrol Dial Transplant. 2006;88–92.
30.
Watanabe Y, Fujii H, Aoki K, Kanazawa Y, Miyakawa T. A cross-sectional survey of chronic kidney disease and diabetic kidney disease in Japanese type 2 diabetic patients at four urban diabetes clinics. Inter Med. 2009;411–4.
31.
Barrios V, Escobar V, Murga N. Clinical profile and management of hypertensive patients with chronic ischemic heart disease and renal dysfunction attended by cardiologists in daily clinical practice. J Hypertens. 2008;(11):2230–5.
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