Praxis Medica
Sign in
Issue image

More articles from Volume 44, Issue 2, 2015

Awareness, habits and behaviors associated with the oral health of children in elementary schools on Kosovo and Metohia

Organization and collagen volume density of the gingiva in the patients with periodontitis

Research on presence of chosen risk factors for hypertension in medical students

Impact of adipose specific peptides on the course and prognosis of myocardial heart attacks

Pain and justification from dental intervention

Citations

Crossref Logo

0

Leucoariaosis influence on cognitive status of patients with lacunar brain infarcts

S. Filipovic-Danic ,
S. Filipovic-Danic
View authors publications

Search this author on:

PubMed | Google Scholar
V. Mitrovic ,
V. Mitrovic
View authors publications

Search this author on:

PubMed | Google Scholar
B. Bisevac ,
B. Bisevac
View authors publications

Search this author on:

PubMed | Google Scholar
N. Milosevic ,
N. Milosevic
View authors publications

Search this author on:

PubMed | Google Scholar
D. Ljusic
D. Ljusic
View authors publications

Search this author on:

PubMed | Google Scholar

Published: 01.06.2015.

Volume 44, Issue 2 (2015)

pp. 41-45;

https://doi.org/10.5937/pramed1502041f

Abstract

Leukoaraiosis is a change in brain white matter with characteristic manifestation in MR and CT head scans. Common leukoaraiosis risk factors include aging and arterial hypertension. A quarter of symptomatic ischemic infarcts belongs to small blood vessel disease group and could be presented as lacunar infarcts. These two crucial pathophysiological mechanisms are in the root of cognitive dysfunction related to small blood vessel disease. 60 lacunar infarct patients were examined and parameters for groups with and without leukoaraiosis were determined. It was found that leukoaraiosis incidence was highest in the group of women older than 70. Neurological assessment was scored on NIH-NINDS scale, functional status was scored with Barthelo index, and cognitive status was determined using Mini Mental State Examination (MMSE) and Alzheimer Disease Assessment Scale Late (ADAS-L). Correlation analysis of these parameters on significance level of *p<0.05, **p<0.01, suggests decrease in neurological status and cognitive performance.

Keywords

leucoaraiosis,

lacunar brain infarcs,

cognition

References

1.
Inzitari D. Leukoaraiosis: An Independent Risk Factor for Stroke? Stroke. 2003;2067–71.
2.
Breteler M, Van Swieten J, Bots M, Grobbee D, Claus J, Van Den Hout J. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam study. Neurology. 1994;1246–52.
3.
Fisher C. The arterial lesions underlying lacunes. Acta Neuropathol (Berl). 1968;(1):1–15.
4.
Leys D, Henon H, Mackowiak-Cordoliani M, Pasquier F. Poststroke dementia. Lancet Neurology. 2005;752–9.
5.
Danic F, Mitrovic S, Milosevic V, N. Faktori rizika za nastanak lakunarnih infarkta mozga. Praxis medica. 2012;(1–2):81–6.
6.
Streifl Er J, Eliasziw M, Benavente O, Alamowitch S, Fox A, Hachinski V, et al. North American Symptomatic Carotid Endarterectomy Trial Group. Prognostic importance of leukoaraiosis in patients with symptomatic internal carotidartery stenosis. Stroke. 2002;1651–5.
7.
Miyao S, Takano A, Teramoto J, Takahashi A. leukoaraiosis in relation to prognosis for patients with lacunar infarction. Stroke. 1992;1434–8.
8.
Rockwood K, Moorhouse P, Song X. Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to investigate vascular impairment of cognitin (CIVIC) cohort study. Journal of Neurological Sciences. 2007;106–12.
9.
Rost N, Fitzpatrick K, Biffi A, Kanakis A, Devanw, Anderson C. White matter hyperintensity burden and susceptibility to cerebral ischemia. Stroke. 2010;(12):2807–11.
10.
Miki Y, Sakamoto S. Age-related white matter lesions (leukoaraiosis): an update Brain Nerve. 2013;(7):789–99.
11.
Pavlović D. Neuropsihološka dijagnostika i neurobihevioralna procena. 1996;
12.
Putaala J, Metso A, Metso T, Konkola N, Kraemery, Haapaniemi E. Analysis of 1008 consecutive patients aged 15 to 49 with fi rst-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke. 2009;1195–203.
13.
O’sullivan M, Leukoaraiosis. Pract Neurol. 2008;26–38.
14.
Danić ELIOCSOPWLBIF, Mitrović S, Biševac V, Milošević B, Ljušić N, D. Department of Neurology, Medical faculty Priština, Kosovska Mitrovica SUMMARY Leukoaraiosis is a change in brain white matter with characteristic manifestation in MR and CT head scans. Common leukoaraiosis risk factors include aging and arterial hypertension. A quarter of symptomatic ischemic infarcts belongs to small blood vessel disease group and could be presented as lacunar infarcts. These two crucial pathophysiological mechanisms are in the root of cognitive dysfunction related to small blood vessel disease.

Citation

Copyright

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Most read articles

Indexed by
DOAJ
Google Scholar
ERIHPLUS
MIAR I
Crossref