Uvod: Dispepsija je čest gastroenterološki sindrom koji značajno narušava kvalitet života. Infekcija bakterijom Helicobacter pylori (H. pylori) ključni je faktor u razvoju organske dispepsije, dok njena povezanost sa funkcionalnom dispepsijom ostaje predmet istraživanja. Cilj: Ispitati prevalenciju H. pylori infekcije kod pacijenata sa dispepsijom i njenu povezanost sa simptomima, endoskopskim nalazima i hematološkim parametrima Metode: Retrospektivna studija obuhvatila je 117 pacijenata sa dispepsijom pregledanih tokom 2023. godine na Internoj klinici KBC Priština-Gračanica u Lapljem Selu. Svi su podvrgnuti gornjoj gastrointestinalnoj endoskopiji i testiranju na H. pylori antigen u stolici. Analizirani su demografski podaci, simptomi, endoskopski i hematološki nalazi. Rezultati: H. pylori infekcija je potvrđena kod 63,25% pacijenata, bez značajne razlike između polova. Zabeležen je trend porasta prevalencije sa godinama, ali bez statističke značajnosti (p=0,060). Epigastrični bol (p=0,0068) i gorušica (p<0,0001) su bili značajno češći kod H. pylori pozitivnih pacijenata, dok su hronični gastritis (p=0,005) i duodenalni ulkus (p=0,029) bili dominantni endoskopski nalazi kod ove grupe. Značajno veći procenat H. pylori pozitivnih pacijenata imao je snižene vrednosti broja eritrocita i hemoglobina u odnosu na negativnu grupu (p<0,01). Prosečan hematokrit bio je niži u H. pylori pozitivnoj grupi (p=0,013), ali se nije značajno razlikovao od referentnih vrednosti. Zaključak: H. pylori infekcija je česta među pacijentima sa dispepsijom i povezana sa specifičnim simptomima, patološkim endoskopskim nalazima i hematološkim promenama. Testiranje na H. pylori je ključno u proceni dispepsije, dok H. pylori negativni pacijenti sa upornim simptomima zahtevaju dodatnu dijagnostiku. Ključne reči: Helicobacter pylori; dispepsija; simptomi; endoskopski nalaz; hematološki parametri
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