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THE MATHEMATICAL MODELS OF ALBUMIN AS DIAGNOSTIC PARAMETERS OF BLOOD-BRAIN BARRIER STATUS
Institute of Biochemistry, Medical faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute of Biochemistry, Medical faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute of Biochemistry, Medical faculty Pristina , Kosovska Mitrovica , Kosovo*
Clinic for Infective Diseases, Clinical Center Pristina, Gracanica
Institute of Biochemistry, Medical faculty Pristina , Kosovska Mitrovica , Kosovo*
Published: 01.01.2009.
Volume 37, Issue 1 (2009)
pp. 39-42;
Abstract
The increased protein concentration in cerebrospinal fluid is among most prominent biochemical parameter of intensified passage of macromolecules through blood-brain barrier. It is often found in cases of meningeal inflammation, neurodegeneration, neoplastic and traumatic processes developed on brain or spinal cord structures. Protein concentration in cerebrospinal fluid is often determined, but determination of albumin concentrations as well as mathematical models utilizing albumin are more reflective to the pathologic processes on the brain and spinal cord. Our study was limited to the determination of referent values for our laboratory for cerebrospinal fluid albumin concentrations, albumin quotient, as well as albumin transudat and exudat in the function of the age of probands. The results of the study show great agreement with previously published data.
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