Vulva can easily be examined, therefore it could be expected that any changes that may emerge at it would be easy to notice and treat quickly and efficiently. Despite that, the incidence of pre-malignant and malignant changes is increasing. Many risk factors connected to the emerging of these changes have been discovered, but many explanations have become available only when the theory of the participation of HPVin oncogenesis has been set. The goal of the study is to identify all the pathological changes at vulva - benignant, pre-malignant and malignant, according to the age of the patients, and therefore, both biopsy and operational material collected from 1331 patients treated at GAK “Narodni Front” Belgrade, has been used. There have been 46 diagnoses of benignant changes, of which 20 (43,48%) had been diagnosed as condylomata acuminata, a change including a HPV infection. Most of these changes have occurred at patients aged 31-40. In 17 cases of pre-malignant changes, VIN I has occurred in 2 cases (11,76%), and VIN II and VIN III as more serious pre-malignant lesions were noticed in 8 samples. In 7 cases (41,18%), VIN III was discovered to be moving into a starting invasion phase. It can be concluded that VIN is most often at patients aged over 60. Malignant vulva tumors occurred in 14 cases, 13 of those where diagnosed as invading planocellular carcinoma, and one of them was metastatic. Vulva carcinomas seem to occur most often at patients aged over 60.
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