In essential hypertension, hemodynamic changes in systolic and diastolic function acompany left ventricul hypertrophy ussualy. Both of these cardiac function can be detected with echocardiography and were measured during this study. 23 patients with moderate essential hypertension were treated with cilazapril plus small doze of diuretic (hydrochlorothiazide) once daily for 120 days. On the begining we found diastolic disfunction, but after the treatment there was a significant improvement in isovolumic relaxation time, early diastolic filling pattern and normalized left ventricular early/ atrial filling ratio. Cilazapril + diuretic combination in a dose once daily controlled blood pressure satisfactory, too. Parameters of systolic function were in the normal levels and there were no significant changes between the two determinations. Thickness of the interventricular septum and posteroinferior wall did not change significantly after 16 weeks of therapy, probably because of too short time of investigation.

Although nowadays is importance of surgery as primary method of gestational trophoblast disease treatment smaller than earlier,appliance of the surgical procedure is still valuable addition to the modern therapy of these diseases. We present a patient with mola hydatidosa where hysterectomy had been done as operative way of this disease treatment.

Ahigher concentrations of microorganisms in the vagina can lead to preterm delivery. Bacterial vaginosis is a well known risk factor of preterm delivery. Aim of this study was to estimate the presence of bacterial vaginosis as a potential cause of preterm delivery relative to the patients with term delivery, as well as to define the type of present bacteria. The results of our investigation showed more frequent presence of bacterial infection of the vagina in the patients with preterm delivery. The following bacteria have been cultured in the group of patients with preterm delivery: Streptocossus agalctiae, Enterococcus, Staphylococcus sp. and Escherichia coli. In prevention of preterm delivery, we recommend a routine screening of pregnant women (such as obtaining smears to bacterial infection) as well as administration of the therapy in case of positive findings, particularly in those presenting a risk for the development of bacterial vaginosis and preterm delivery. 

Besides big improvement of diagnostic, therapeutic and preventive procedures vascular disease generally and vascular disease of brain remain of biggest importance in total morbidity and mortality. This examination included patients in Urgent Surgery Center “Simonida” Gracanica. In article is represent relationship between brain and heart dysfunctions and it is obvious that cerebral disturbances can cause heart disturbances and also it can be in opposite direction. Well, based on this is very important to make fast and correct orientation: CARDIOCEREBRAL or CEREBROCARDIALSYNDROME. In diagnostic procedure and therapeutic treatment is necessary cooperation between cardiologist and neurologist because in most of these cases we have cardiocerebral or cerebrocardial syndrome. Better treatment patients with brain stroke claim teamwork different specialist.

Stress ulcer presents acute lesion of gastric mucosa, which resulted from influence of different stressors: trauma,
shock, burns, drugs administration, various irritants etc. Since pathogenesis of stress ulcer is not completely clarified, the
most adequate therapy for the patients which suffer from it, is not defined yet. Esomeprazole is a S-isomer of omeprazole
and is the first inhibitor of proton pump synthesized as an isomer. Our aim was to test effects of esomeprazole, given during
pretreatment and posttreatment period, on progress of alcohol induced stress ulcer lesions. We had experiments on sexually
mature Wistar rats weight 200-250 g. Alcohol stress was induced by intragastric administration of 1 mL 96% alcohol.
Alcohol stress produced massive submucosal lesions in glandular part of stomach. Macroscopic lesions were verified
histologicaly. Intragastric pretreatment administration of esomeprazole (20 mg/kg BW) significantly (p<0,001) reduced gastric lesions. Intragastric post-treatment administration of esomeprazole (20 mg/kg BW) did not reduce gastric lesions. Esomeprazole (20 mg/kg BW) administrated in pretreatment period of alcohol induced stress significantly decreased dimensions of stress ulcer lesions in rats, while the same dose administrated in posttreatment period did not cause that effect.

Bacterial meningitis is an important medical problem, as because of the use of powerfull antibiotics and other
drugs, and therapeutic measures, the number of patients, as well as the mortality haven't been changed for years. Because of that the study of pathogenesis of bacterial meningitis has been one the most dynamic researsh fields in recent years. Meningitis caused by salmonella is not usual clinical manifestation of salmonella infections, but because of fulminant evolution and specific structure of cause. Path and effect of diseases, it deserves special attention. Our researches encompases 29 children who suffer from salmonella meningitis. Out of the whole number of cured children, the moust frequent was at newborn (58,6%), while the smallest number was in the group of older infant (6.9%). Concernig the sex structure of diseased, the biger number was at male (62.0%). The most important finding in liquor cerebrospinalis at patients is polymorphonuclear leucocytosis (average value of cell elements is 3744, with 82% polymorphonuclears). At the same time existed leucocytosis in peripheral blood with sigificant deviation into left. At all our patients hypoglycorachya expressed (1.45mmol/L). The value of proteinorachya was 1.71 g/L. The result of the disease was successful in 49.3%, died 24,1%, and cured with consequences 27,6%.

Today it is noticeable that the incidence and mortality from cervical carcionoma increases, especially the growth of
frequency of those changes at younger women. The total number of diagnosis of invasive carcinoma at the processed biopsy and operative matrials was 186. The majority of results were the histological grade G1 N1 54,83% in the group of 41-50 years old patients, and the less significant was number of histological grade G2 N2 at the age 51-60 and G3 N3 at patients over 60 years old. In 72 cases the radical surgical treatment was done after previously made HP diagnosis of planocellular carcinoma on the biopsy material, and it was done in the cases that were operable in stage Ib (FIGO). The most of operated women were with histological grade G1 N1, so we followed in what degree the size of tumor, beside the histological grade G1 N1, so we followed in what degree the size of tumor, beside the histological grade, have an effect on the possibility of presence of the metastasis in regional lymphatic nodes. We came to the conclusion that with the growth of macroscopically size of tumor, the frequency of appearance of lymphatic nodes increases. Those parameters could not the small number of operated cases. When the disease is discovered in these histological grades. It is not operable, and then we perform radiotherapy as a method of treatment.

Nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) today is the most powerful review method of a human body. Method is based on effect strong magnetic field and on demonstration of natural physical characteristics of nucleus. Hydrogen atom is a part of almost every compound in our body (water, lipids, proteins and nucleid acids).
When we exposed body to strong magnetic field hydrogen nucleus orients in direction of field, which cause resonance and
6 8 emission of radio signals. Resonance frequency for MRI is in range from 10 Hz to 5x10 Hz, which is equal to energies from -28 -25 6x10 J to 3x10 J.

In February 2000, in Pancevo, 71 persons suffered from trichinosis. Of that number, 47 were hospitalized. In one of
the cases, which is a subject of this work, patient developed clinical feature of encephalitis. Encephalitis was diagnosed
based on clinical feature, EEG and spine fluid results. In the another case, that this work also deals with, toxic myocarditis
was developed. This diagnosis is based on clinical feature, changes in ECG and ultrasound of heart. Changes in ultrasound
of heart were noted 33 days after first symptoms had occurred.

The genes mutate either spontaneously or under the influence of mutagenic agents (irradiation, viruses, toxins).
The occurrence of genetic syndromes in the scope of one family is pointing more to the inherited than to de novo mutation.
Aim of this study was to present two syndromes in the same family tree, occurring subsequently one by one, which carry severe mental retardation and have a poor prognosis and frequently tragic outcome. A case report was given of a patient in
whom both pregnancies were completed by birth of the newborns presenting with severe syndromes: the first one with
Down's syndrome and the second one with Prader-Willi-Labhart syndrome. The results of investigation point to the necessity of genetic investigations before pregnancy and during pregnancy as early as possible, in order to avoid giving birth to
the children with syndromes which bear severe mental retardation and having poor prognosis.