In the study with experimental animals in vitro conditions, the aim of the research was to examine the effect of verapamil on the even brawniness of the isolated organ of the respiratory ways (tracheas) in guinea-pigs on acetylcholine and histamine, and in that way, to examine local mechanisms of smooth muscle system but also to exclude the rest of the neurohumoral influences. The guinea-pigs of both sexes (average weight of 500-700 gr), were used for this experiment. 10 guinea-pigs were included in the experimental research; the trachea was taken from them after the immolation. The preparations of isolated organs of trachea were divided into two groups (A and B). The previous incubation of trachea -5 isolated by verapamil (1 minute) in concentration 10 M significantly reduced the contraction caused by acetylcholine -4 (ascent 21.49±9.63, r=0.97, p<0.05). Concentration of verapamil 10 M also caused significant fall of contraction (ascent -5 21.3±12.63, r=0.95, p<0.05). Verapamil in concentration 10 M significantly reduces the response of isolated trachea cau- -6 -5 -4 sed by histamine in concentrations 10 M and 10 M (slope 21.3±10.6, r=0.96, p<0.05).Concentration of verapamil 10 M significantly reduced the contraction of smooth muscles of isolated trachea caused by histamine (slope 15.46±10.47, r= 0.94, p < 0.05).

Serious metabolic diseases and infections, such as sepsis, may lead to the occurrence of stress ulcers. Unfortunately, in our hospitals, the stress ulcer is often diagnosed as a separate disease, not as the manifestation of the existing stress status of the patient. Therefore, the goal of this pilot study was to establish the incidence of stress ulcers in sepsis patients treated at the Infective Disease Clinic. Patients treated at the Military Medical Academy Infective Disease Clinic during 4 month period, who experienced acute bleeding, verified gastroscopically, were subjected to retrospective analysis. Five out of 344 hospitalized patients had serious hemorrhages. Out of a total of 21 patients diagnosed with bacterial sepsis, acute gastric bleeding was verified gastroscopically in three, or 14.28 percent. To obtain more data, prospective long-term study, wich would include greater number of septic patients, should be conducted.

The existence of left ventricular hypertrophy is an independent prognostic factor for cardiovascular morbidity and mortality. Heterogenous factors lead to left myocardial hypertrophy. The most frequently factors are: arterial hypertension, valvular heart disease (aortic stenosis and insufficiency, mitral insufficiency), hypertrophic myocardiopathy, left myocardial hypertrophy after myocardial infarction... For making the diagnosis of left ventricular myocardial hypertrophy used electrocardiography („voltage“ and „repolarization“ criteria) and echocardiography. Echocardiography is the gold standard for diagnosis of left ventricular myocardial hypertrophy. Left ventricular mass was estimated by the modified formula 3 3 using measurements obtained in accordance with the Penn convention: MLK = 1,04 (LDDd+PWDd+IVSDd) - (LVDd) - 13,6 Where LDDd is diastolic left ventricular internal dimension, IVSDd is diastolic ventricular septal thickness and PWDd 2 is diastolic posterior left ventricular wall thickness in diastole. LV mass indexed by body surface area (g/m ). By Penn con2 2 vention left ventricular hypertrophy criteria were ≥134 g/m for men and ≥110 g/m for women.

Seronegative arthropathy represents group of rheumatic diseases which affects younger patients, more often male. Ocular findings are numerous such as conjunctivitis, iridocyclitis, and they are a part of extraarticular clinical manifestations. Acute anterior uveitis, as most common ocular manifestation, could be a sole or associated morbidity condition at the forme of systemic diseases.

Family planning is a civilizational value that should lead to a reduction of abortions, especially abortion as a method of family planning. Contraception or pregnancy prevention is the most purposeful way of birth control. It includes all the means and methods to a certain point, and certainly before the implantation of blastocyst, they stop the natural process of reproduction. The aim of our study is to analyze the application of some method of contraception among women who had and who had an early abortion in the sample and to analyze the application of some method of contraception in the study group of women and their correlation with the attendance of education in counseling contraceptive after intentional interruption of early pregnancy. A significant change in the use of contraceptive after pregnancy termination, and conducted training in family planning, is that the increased incidence of permanent contraceptive methods, compared to their occasional use.

The middle of last century it was established that the increased value registered fibrinogen in patients with coronary disease, hypertension, peripheral artery disease, patients with diabetes mellitus. Fibrinogen also participate in the earliest stages of atherosclerosis.Task of our research was to compare the level of fibrinogen in patients of type 2 diabetes mellitus without complications, and manifested in patients with apparent chronic complications as well as the correlation of fibrinogen with the parameters of metabolic control. Included 64 respondents, a close age divided into 4 groups: control group, people of type 2 diabetes mellitus without complications, people with microvascular complications, and people with macrovascular complications.The highest average value of fibrinogen in the blood we had in the group with diabetes mellitus without complications (3.47±0.26 g/l) and the lowest mean value in the control group (2.87±0.15 g/l). It is a test of correlation showed a strong correlation with the value of fibrinogen level of development of chronic complications.

The aim of this study was to determine the functional state of the feet of 40 boys aged 12 and 6 moths up to 13 and 6 months and by using the criterion variable of the 500 m run, to carry out a comparative analysis of their running speed. The subjects were divided into three groups: group I which numbered 14 boys with normal feet, group II which numbered 14 boys with high arches (pes excavatus) and group III numbering 12 boys with flat feet (pes planus). The diagnosis of the feet conditions was made following the inspection of the Achilles' tendon and the medial edge of the foot, followed by a plantogram. The statistical analysis of the results from the 500 m run was carried out by means of basic statistics, the analysis of variance (ANOVA) and the Ò criterion used to determine the source of the variability while testing the normality of the distribution. The analysis of the obtained results led us to the conclusion that foot deformities represent a negative factor for the ability to perform the 500m run which is one of the requirements in the battery of tests used in elementary schools. The analysis of variance, ANOVA, has indicated that there are significant differences between the boys in terms of their results for the 500 m run (p=.00). The difference between the average running time of the boys with normal feet and the boys with high arches is not statistically significant, while the differences between the average results of the run for the boys with normal and flat feet, as well as between the boys with high arches and flat feet are statistically significant, which led us to the conclusion that flat feet have a greater negative impact on the running ability than high arches. We can assume that boys with feet deformities (especially the ones with flat feet) will probably be less physically active than boys with high arches, which also leads to their significantly weaker running abilities. 

Acute viral hepatitis A (HAV) is a benign self-limited disease, which does not become chronical and does not require obligatory hospitalization. It's an intestinal infectious disease with a dominantly fecal-oral way of transmission. Endemic epidemic appearance of this disease on the municipality of Prijedor, with a very high level of incidence, from the sixties of the 20-th century, has put the viral hepatitis among the priority problems of epidemiologic practice. During the period 1965-2007. in Prijedor there were 5707 registered cases of HAV contaminated people and three death cases. From 1990 it has been noticed an epidemiologic regression of HAV followed by its complete absence during the period 1997-2007. Studies of reasons of HAV regression have been conducted by a descriptive-epidemiologic method according to sex, age, ethnic affiliation, place of residence, seasonal appearance of disease, and the way of water supply. It has been determined that there is no statistically important differences among contaminated people according to sex, differences in other treated parameters correspond to the data from literature [1,2]. Seroconversion has been proved in 53 persons or 55,2% of tested people. Percentage of sero-positive people was 93,7% among people older than 60 years of age and 79,2% among the refugee population. Based on studies, the epidemiologic regression of HAV from the 90-ties of the 20th century, is explained by the fact that this disease appears in the interepidemic period, that there is a significant collective immunity of population with the HA virus, and the most important, the basic epidemiologic factors which contribute to the spreading of disease have been removed - the majority of population live in the urban and suburban areas where a hygienic water supply has been provided for. Also the customs and habits of population have been significantly changed. 

Organophosphates are famous insecticides which are often used as suicide venoms in Bitola's surrounding. When treating such patients you should gastric washing, keep the airways clear, give Atropin until fully atropinized, give symptomatic therapy. All patients need to be hospitalized. The treatment for this kind of patients is finalized with a psichyatric observation.

A survey was made among the employees of the Health Centre Novi Sad. It included 237 people, of which 99.6% were health workers and 0.4% administrative workers. Among the respondents 8.4% occupied a managing post. The questionnaire included the issues relating to the satisfaction of the employees with working conditions, work-associated fatigue, comparison of the job satisfaction five years ago and now, plans for the next five years, and overall job satisfaction. Based on the answers of the respondents it comes out that only 36.3% of the health workers are satisfied and very satisfied with their jobs, which is a very small percentage regarding the nature of the work they do. However, 42.2% of health workers plan to remain in the public sector in the next five years, and 41.8% do not even think about changing the job. This was logical to expect bearing in mind the material position of the health care and overall economic situation in the society.