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ALPHA LIPOIC LIPOIC ACID IN CLINICAL ACID IN CLINICAL APPLICA APPLICATION
Health centre Kosovska Mitrovica Kosovo*
Institute of Pharmacologhy and toxicologhy, Faculty of Medicine, University of Priština - Kosovska Mitrovica , Mitrovica , Kosovo
Health centre Kosovska Mitrovica Kosovo*
Institute of Psysiology, Faculty of Medicine, University of Priština - Kosovska Mitrovica , Mitrovica , Kosovo
Internal Clinic, Faculty of Medicine, University of Priština - Kosovska Mitrovica , Mitrovica , Kosovo
Published: 01.01.2009.
Volume 37, Issue 1 (2009)
pp. 107-112;
Abstract
Alpha lipoic acid is the most efficient of all known antioxidants for its lipo and hydrosolubility which enable easy penetrability in cytoplasm making its protection of free reactive radicals, energetic metabolism, regulation of genetic expresion etc. It has wide application in prevention and in therapy of diabetic angiopathy, neuropathy, cardiovascular, cerebrovascular, neurodegenerative disease, lesion, (insufficiency) of liver, HIV, intoxication with hard metals, mycotoxins etc. An important proprety of lipoic acid is its possibility to prevent or remove lesions which are caused by application aminogycosides and haloperidol (ototoxicity, nephrotoxicity) according to its wide application. R isomer of lipoic acid is physiological substance presented in organism which synthesize in in liver enabling its its application in relatively high dose for a longer period of time.
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