Diagnosis of different pathohystological diseases of prostate in the most cases based on common benignant and malignant characteristics. The presence of periacinar cleftings (PC) is an additional criterion favouring prostatic adenocarcinoma. The aim of our work was to examine the presence of PC around glands in prostatic adenocarcinoma (PA), prostatic intraepithelial neoplasia (PIN) and benign hyperplasia of prostate (BHP) and to determinate specificity and sensitiveness for their presence in PA. We analysed biopsy material of Institute of pathology, Medical faculty Priština and Department of pathology and forensic medicine Clinical center of Kragujevac from begining of 2007. till the end of 2008. According to the presence and extent of PC, analysed on high power field (400x), glands were classified as: group 1 - glands without PC or with PC affecting ≤50% of gland circumference; group 2 - glands with PC affecting >50% gland circumference in <50% examined glands and group 3 - glands with PC affecting >50% gland circumference in ≥50% examined glands. By the analyse of our material we found PC around glands in PA, PIN and BHP: the most glands in PA were group 2 (34 or 48,6%) and group 3 (31 or 44,3%), in PIN group 1 (12 or 60%) and group 2 (8 or 40%), in BHP glands at all 100% cases were group 1. We found sensitiveness 92,9% and specificity 73,3% for glands with PC at prostatic adenocarcinoma, which indicate that periacinar cleftings represent a reliable criterion in diagnosis prostatic adenocarcinoma. 

The combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting, but also can cause serious hematological side effects. The purpose of this study was to evaluate the effect and interactions aspirin and ticlopidine on hematological variables. Thirty two Wistar rats were divided in four groups and they received intraperitoneal one of the following treatments for 4 days: group I - control, group II aspirin (50 mg/kg BM), group III - ticlopidine (125 mg/kg/day) and group IV - aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day). Hematological variables were determined at once after taking the sample of blood. Relationship between measured variables was determined by calculating linear correlation coefficient (r). The hematocrit, haemoglobin and red blood cell were significantly decreased in group treated with aspirin+ticlopidine combination compared to control (p< 0,05). Neutrophil and platelet count weren't significantly different in treated groups, but were slightly decreased in groups treated with ticlopidine and aspirin+ticlopidine combination. Between hematocrit and platelet count in control group of rats was noticed negative and medium correlation (r=-0,41), in groups treated with ticlopidine and aspirin+ticlopidine combination positive and medium correlation (r=0,52; r=0,69). Based on obtained results it can be observed significant decreased hematocrit, haemoglobin and red blood cell in group treated with aspirin+ticlopidine combination. The negative correlation between hematocrit and platelet count in control group becomes positive after the treatment with ticlopidine alone and aspirin+ticlopidine combination.

Without a knowledge of how drugs are being prescribed and used, it is difficult to suggest measures that would support rational use of drugs and improve prescribing habits in hospitals. In our work we analyzed utilization of antibiotics for systemic use at the Surgical Clinic of the Clinical Hospital Centre - Pristina in Gracanica in 2007. and 2008. on the basis of dispensing records of drugs issued from the Central Pharmacy to the Surgical Clinic for those two years. Antibiotics were distributed according to ATC classification, and antibiotics' utilisation was expressed in number of defined daily doses used per 100 patient-days (DDDs/100 PD). We analized qualitative and quantitative participation of different groups of antibacterials for systemic use. Òhe results of our study were in accordance with available results of similar studies in our country and in the neighbouring environment

Introduction/Aim. +Gz acceleration is unique dynamic stress to organism. Development of this occurrence depends not only to magnitude of acceleration but to onset rate and duration too (1). The most of former researches pointed to +Gz stress as significant stress to basic physiological mechanisms like cardiovascular and respiratory system. The aim of our study was to examine responses of neuroendocrine and immune system to +Gz stress. Method. Examination was performed in two inbred strains of rats Albino Oxford (AO) and Dark Agouti (DA). AO, n=45 and DA, n=60, male, 9-11 weeks old. Experimental animals were subjected to the Test of linear increase of +Gz acceleration (peak 7G, onset rate 0.1 g/s) at the Institute of aviation medicine of Military Medical Academy. Before examination, animals fasted 24 hours. Control group were rats which did not subjected to +Gz acceleration. After the animals were sacrificed we punctured blood from abdominal aorta to examine plasma and serum and extirpated thymus and spleen to be examined, too. In wish to examine effects of +Gz stress to polarization of Th immune response we determined concentrations of cytokines (IFN-ã and IL-4) in the culture of spleen cells. Results. The level of cytokines in the culture of spleen cells stimulated with Con A, isolated from animals (experimental and control group) 3 and 24 hour after +Gz exposure and level of cytokines determined in supernatants, showed statistical significance as it presented on the graphics. Conclusion. According to our research obtained on animals we can conclude that +Gz acceleration in the early period (after 3 hours) decreased IFN-ã in the culture of spleen cells. AO rats showed difference compared to DA rats in reaction to +Gz stress. AO rats had increase in IL-4 in the culture of spleen cells and higher decrease of IFN-ã and emphasized polarization of Th1/Th2 in course to Th2. After 24 hours of exposure to +Gz stress we observed increase of IFN-ã (DA) and increase of IL-4 (AO).

Event-related potential which represents a large positive wave which varies in amplitude and depends on subject's capability as well as on stimulus modality on which subject needs to react and appears around 300 ms after stimulation is called event related potential P300. In 1965. Sutton and the assistants were the first to suggest division of evocated potentials, according to the stimulus that provoke them, on "exogenous" (under the influence of exogenous stimulus) and "endogenous" or "cognitive" provoked by endogenous stimulus, which depends on the state of consciousness (vigilance), attention, concentration and especially, the type of the task a subject needs to perform during the recording. One of the most studied responses of the event-related potentials is so called "P300", the late positive wave complex which appears around 300 500ms after the stimulus. It is gained when the subjects' attention is focused on the signal which rarely appears, especially if the signal has some emotional or motivational meaning. The aim of this work was to determine whether there was a difference in latency and amplitude of the event related potential P300 when the button is pushed with dominant hand compared with nondominant hand in both males and females. The experiment included 30 subjects (15 males and 15 females). P300 potential was provoked with the auditive "oddball" paradigm. Event-related potencial P300 is recorded with 10-20 system. Cz electrode is set in the middle of nazion-inion line, while Fz electrode is set on the third of nazion-inion line above frontal lobe. In classical "oddball" paradigm, when a subject reacted on the signal by pushing the button with dominant hand, the value of Fz end Cz latency was significantly shorter in comparison to the values of Fz end Cz latency gained by pushing the button with non-dominant hand (left hand) in males, while such differences were not found in females. 

Among all ALS procedures, effective airway management is vital in the treatment of critically ill patients. The aim of this study was to evaluate the impact of pre-hospital endotracheal intubation and early defibrillation on outcome of cardiac arrest (CA) patients. We examined 200 patients suffering from out-of-hospital cardiac arrest (OHCA) in a prospective cohort study in a two years period. We determined survival from CA to discharge from hospital and the factors associated with survival. We calculated the time intervals until shock decisions were made. Shock decisions were verified according to EKG downloads. 52% of patients were intubated in the field, survival to discharge from hospital was significantly higher among patients who were intubated in the field. Survival rates in patients with VF/VT was 9.7% compared to patients with asystole/PEA (1.6%). 66.7% of patients were given the shock after 4 minutes. Low survival to hospital discharge may be due to low number of CA patients who were intubated in the field and long "interval to shock delivery" (there are no AED). Existing literature shows that the first minutes are a critical time frame for successful resuscitation and this is an argument towards the introduction of AEDs used by bystanders.

Because of significance of self-rated health as a valid measure of health status it is important to research what influence on individuals when they assess own health.. The aims of the study were to investigate how north Kosovska Mitrovica adults describe their health and to compare results with results from Serbia without Kosovo and Metohija; and to determine which variables are connected with self-rated health status among this population. The research was conducted as crosssectional study, done on the representative sample of adult citizens in northern Kosovska Mitrovica in the year 2006. 318 examinees were examine. The instrument of research was a questionnaire which contained questions about self-rated health and demographic and socio-economic characteristics, mental health, social interaction, capability of daily activities, health behaviour and habits, diseases and injuries, utilization of health care service. Independent variables are defined through fac2 tor analysis taken from these groups of question. For statistic analysis were used X -test and multivariate stepwise linear regression. More than half of the respondents (54,7%) their health assessed as good or very good. Inhabitants of northern Kosovska Mitrovica were significantly often their health assessed as good or verz good than inhabitants of Serbia without Kosovo and Metohija (p<0,05). Self-rated health were connected with foreword variables: gender, mood problems, myocardial infarction, chronic bronchitis, psychic and neurotic disorders, rheumatic arthritis, high blood sugar, utilization of private gynecologist service and paying for diagnostic service. Results from this study correspond with findings from literature. Most of the respondents in north Kosovska Mitrovica assessed their own health as good or very good. Bad and very bad health was significantly associated with females, problems with mood, myocardial infarction, chronic bronchitis, psychic or neurotic disorders, rheumatic arthritis and high blood sugar. Good and very good health was significantly associated with utilization of private gynecologist service and paying for diagnostic service. 

The objective was to determine the type of venom poisoning causes accidental, sex, age, occupation, place where the poisoning and seasonal distribution. The work was carried out comparative analysis of accidental poisoning in Belgrade in two five-year period 1965th to 1969. and since 2000. by 2004. year. The structure accidental poisoning in the first mentioned period dominated by gas poisoning (CO) and alcohol, and in the second period, poisoning psychoactive substances. In both the five-year period were more likely to be poisoned males. In the first study period, were often poisoned persons older age groups, while in the second period there was a shift to younger age groups. Between 1965 and 1969 and were significantly more frequent poisoning among farmers compared to the period 2000-2004, when they are significantly more common poisoning in students and the unemployed. The highest percentage of poisoned in both investigated period, was found in our own home with no signs of life. Accidental poisoning occurred more frequently in the winter months in the first study period, while in the second period seasonality is not expressed.

Renal osteodystrophy is significant medical, economic and social problem. Over 90% of patients receiving chronic dialysis are facing some type of renal osteodystrophy. The objective of the study is to determine correlation between clinical and radiological findings in patients with renal osteodystrophy. Clinical study was performed in 60 adult patients, different sex and ages, receiving chronic dialysis, with developed renal osteodystrophy. All patients were having following symptoms: bone pain, muscle and joint pain. Muscle spasm were registered in 68.3% of patients, while proximal myopathy symptoms were registered in 86.6%.Dominant radiological findings were: subperiosteal resorption in 53.3% of patients, diffuse osteoporosis in 48.3%, rugger jersey in 33.3% and soft tissue calcification in 18.3%. We have registered statistically significant correlation of clinical and radiological findings. With this study we have confirmed that different types of renal osteodystrophy can be determined by comparing radiological, clinical and biochemical findings, especially in cases when bone biopsy cannot be performed.

Materials wich use like base,and those used for direct and indirect capping should be, except certain physicalchemical and biological performance have and antibacterial effect, to act after the application on residual microorganisms. The aim of this study is that in vitro display antimicrobial activity of some selected resources that are used to protect the dentin below the permanent restoration, and some of this as medication in treating deep surface carious lesions and to directly cover any caries, either artificially open pulp. Antimicrobial activity was tested against microorganisms. On agar plates into the grooves 4 mm in diameter was inserted freshly prepared paste or base. After inserting the material into the surface of bloî od agar, was performed by incubation under aerobic conditions for 24 h in a thermostat at 37 C. Negative effect on the microorganisms, tested materials, it was estimated by the size of growth inhibition zone.

The aim of the research was to use a system of 25 variables of morphological characteristics on a sample of subjects numbering 200 top athletes, all males (50 handball players,50 volleyball players, 50 basketball players, 50 soccer players), aged 18 to 30, in order to determine their factor structure, which would be in aid of more rational procedures for the continual selection of athletes in these sports and the transformational training process. By means of the component analysis (the direct oblimin) and the GK criterion (ë≥1.00) used to obtain the common characteristic roots and the explained segments of common variance, five latent variables were isolated for the handball players (body mass and voluminosity and the subcutaneous fatty tissue of the upper body, the longitudinal dimension of the skeleton, the subcutaneous fatty tissue of the lower extremities and upper àrm, the transverse dimension of the lower extremities, the transverse dimension of the elbow and shoulder), six latent variables for the volleyball players (the transverse dimension of the wrist and body volume and mass, subcutaneous fatty tissue of trunck, longitudinal dimension of skeleton, the transverse dimension of knee and foot length, lower leg skin folds and fatty tissue of the upper arm,elbow diameter), another five latent variables for basketball players (the longitudinal dimension of the skeleton, body mass and voluminosity and subcutaneous fatty tissue of the trunck, the subcutaneous fatty tissue of the lower extremities and upper arm, transverse dimension of the lower extremities and the wrist, the transverse dimension of pelvis) and six latent variables for the soccer players (the longitudinal dimension of the skeleton, the subcutaneous fatty tissue of the lower extremities and upper arm, body mass and voluminosity, the transverse dimension of the legs, shoulder and hand, the subcutaneous fatty tissue of the trunck, transverse dimension of the arms). On the basis of the identified factor structures of the latent variables, it can be concluded that we are dealing with a case of different morphological structures of the different athletes. 

Bacterial meningitis is an infectious disease, with potentially fatal outcome, where the main event reflects inflammation of soft meninges and associated phenomena on the other structures of the central nervous system. Despite the use of powerful antibiotics and other drugs and therapeutical measurements, the number of diseased, as well as the mortality from this suerious disease, are not changed for years. The most common pathogens of bacterial meningitis in children age are H.influenzae, S.pneumoniae and N. meningitidis. Other significant causes are Streptococcus B, E.colli, L.monocytogenes, Salmonella, Pseudomonas and other Gram-negative bacteria. Our research included 120 children sufferin from bacterial meningitis. Out of the total number of treated children, the highest incidence was in age of infants (51,6%), and regarding to the gender structure, male were somewhat more frequent (54,6%). The most significant unfavorable factors for occurrence of sequalea were: younger age, the type of bacteria, bacterial concentration in cerebrospinal fluid, the time required for liquor sterilization, hypoglycorrhachia, focal neurological sings and convulsions. Complications could relate to the central nervous system or some other organic systems. Convulsions are the early complications of bacterial meningitis. Hearing impairment is often present with severe forms of bacterial meningitis with convulsions, prolonged febrile state and presence of hypoglycorrhachia. Epilepsy is rare, late sequelae, while hydrocephalus is more likely to occur in neonatal meningitis. Heavy neurological damage occures in 5% of the children.

We treated 15 subfertile men with varicocele with combination of subinguinal ligature of spermatic vein or plexus pampiniformis and medicaments. In a five-year period , we registered 5 pregnancies (30%) in female partners of our patients. We consider subinguinal ligature of spermatic vein as minimally invasive and cost-effective initial treatment of "infertile couples".

According to the relevant investigations during past decade there is a great increase of malignant skin tumors. By this research we tried to investigate this hypothesis in domestic population and present complicated reconstructive procedure. In this research were included 591 patients with melanomas and carcinomas of head and neck who were surgically treated at our clinic from August 2000. to October 2008. Results of this research showed that 50 patients had melanoma and 541 carcinomas of skin. We have found that men are affected by skin facial carcinomas four times as much as women. The most common location of plano cell carcinoma was the skin of the auricle and lips, while basal cell carcinoma was mostly found on the nose. 62% patients with squamous cell carcinoma who were primary surgically treated survived more than 5 yr. 85% patients with basal cell carcinomas survived more than 5 yr.

Ankylosing spondylitis is a chronic rheumatoid inflammation with characteristic synovitis of sacroiliac joints and vertebrae of spinal column and fewer coxofemoral and glenohumeral and periferal joints. The disease is of an unknown etiology and shows strong correlation with histocompatibile antigene HLA-B27 wich is found in 90% AS diseased patients. Acute anterior uveitis is the most frequent extra-articular manifestation, it can precede spondylitis and is found in at least 20% AS diseased patients. Acute anterior uveitis is mostly bilateral, with recidives and in inadequate treatments results in complicate cataract and secondary glaucoma. Out of 41 patients with ankylosing spondylitis 36 (87.8%) is of male , and 5 (12.1%) female sex (ratio 9:1). The youngest patient was 25 and the oldest 69 years of age, average age of the diseased was 38.45. Acute anterior uvetis is found in 11, that is 26.8% diseased patients. The length of uveitis is approximately 28+/- 10 days. In 7 patients (63.64%) AAU is found in both eyes. Out of 11 patients with with AAU, 3 patients (27.27%) had more than first attack,7 (63.64%) had 1-5 recidives, and only 1 patient had more than 5 recidives. The most frequent type of exudation is serofibrose (77.78%), then follows fibropurulent-hypopyon (16.67%) and serose (5.55%). Out of 18 eyes, in 14 (77.78%) back synechies were formed. However, these synechies are in most cases broken by the use adequate therapy.

Hyperprolactinemia is the most common hypothalamic-pituitary axial disorder which is found in clinical practice. Increased level of prolactin, regardless of the cause, results in disorder of gonadal function and infertility, while normalization of the level of prolactin is associated with establishment of normal gonadal function and fertility. Establishment of the correct diagnosis is a great significance, because it is possible to normalize the level of prolactin and establish normal function of ovaries in more than 90% cases with specific therapy. The objective of the work is to study concentration of prolactin in each phase of menstrual cycle, its impact (influence) on FSH, LH and E2, as well as the influence of hyperprolactinemia on the rhythm of menstrual cycle. The study has encompassed 150 of women in reproductive period, from 18-40 years of age. The control group includes 50 of women, and there are 100 of women with menstrual cycle disorders (oligomenorrhea, polymenorrhea and secondary amenorrhea) which causes hyperprolactinemia. The turnout of hyperprolactinemia in causes the disorders of menstrual cycle (oligomenorrhea, polymenorrhea, amenorrhea) is 83%, on the basis of the results, wich demonstrates a serious problem and justifies a scientific study.

Doppler ultrasound check-up significantly increases a possibility of initial functioning of arteriovenous fistula. The aim of the study was the preoperative evaluation of vascular system of the extremity for creation of arteriovenous fistula for haemodialysis. The examination was organized at Urology and Nephrology Clinic, Clinical Centre "Kragujevac". The examined subjects were 87 patients, 52 (59,8%) male and 35 (40,2%) female, mean age of 61±11,1 years. There were performed the routine biochemical analyses, demographical structure and clinical characteristics (type of anastomosis, fistula placement, arterial blood pressure, lumen size of the artery and vein, measured intraoperatively by Doppler technique). In 72,1% of patients with functioning fistula there was made a terminal-lateral anastomosis, compared to 57,7% of patients with initial non-functioning fistula, there was found a statistically significant difference between the groups p=0,008. Radiocephalic fistula was created in 62,3% of the examined patients with initial functioning , in patients with non-functioning, the distal fistula was created in 38,5% of the examined patients. Regarding the type of the fistula location there was obtained statistically significant difference; p=0,04. There was found a statistically significant difference between the group of patients with initial functioning of arteriovenous and the group without, concerning the intraoperatively measured lumen of the cephalic vein (2±0,29 vs. 2±0,38 mm); p=0,03 (2,1±0,5 vs. 1,8±0,4); p=0,0009. Statistical significance between the groups was also found in the lumen of the cephalic vein verified by the ultrasound (2,1±0,53 vs. 1,8±0,25 mm); p=0,038. Peak of the systolic speed of the radial, corelated to the group of patients with and the group without initial functioning fistula (50 ± 12,42 vs. 40 ± 6,9 cm/sec); (p=0,0026), has statistically significant value. By the correlation of the group of patients with initial functioning and the group of patients without initial functioning, regarding hemoglobin (97 ± 16,1 vs. 88 ± 18,3 g/l); p=0,006 and the level of urea (22,6 ± 12,7 vs. 23,9 ± 9,8); p=0,02, there was found a statistically significant difference. Color Doppler ultrasound has an important role in preoperative evaluation of blood vessels and it represents a meaningful predictive parameter of functioning of arteriovenous fistula. 

Biological equality assessments are carried out by means of: a) comparative pharmacokinetic study; b) comparative pharmacodynamic study; c) controlled comparative clinical experimentation; d) comparative in vitro assay (dissolution test). The first method mentioned, i.e. determining the concentration of a drug in the blood of healthy volunteers, is the most accurate and most frequently employed. In this paper, a study conducted on healthy volunteers that displays the possibility of evaluating biological equality using pharmacodynamic variable data, giving the example of such assay of retard tablets of verapamil produced by two different companies, is presented. Taking into account the effects of this drug, biological equivalence was proved by comparing pharmacodynamic variables such as PR interval, systolic and diastolic blood pressure and heart rate.

Background: In hernia inguinal regions that are usually on the front wall of the belly may appear epigastric, umbilical and postoperative (incision-ventrale) hernia. Incision (postoperative-ventral) hernia is the kind of hernia that occurs in the area before surgical incision made through the entire thickness of the abdominal wall. Purpose: The aim of this paper is to indicate the frequency incision, epigastric and umbilical hernia, and the validity of some methods used in surgical treatment. Materials and methods: The making of the material used Surgical Clinic KBC Pristina in Gracanica. This prospective study we included 107 (3.43%) patients with hernia abdominal front wall, which were operated in the Surgical Clinic from 2003- 2009th year. Results and discussion: the anterior abdominal wall hernia, are recorded in 48 (44.86%) male patients and in 59 (55.14%) female patients. Age is of great influence on the frequency of anterior abdominal wall hernia, because we have the largest number of hernia 45 (43.14%) recorded in patients older than 61 years. Free hernia we found in 68 (63.55%) and hernia incarcerate of 39 (36.45%) patients. Incision (postoperative) we found a hernia in 44 (41.12%), umbilical in 36 (33.65%) and epigastric of 27 (25.23%) patients. Postoperative hernia is most often occurring after longitudinal laparotomia. We have them registered in 19 (43.18%) patients with infraumbilical, in 10 (22.72%) with supraumbilical, in five (11.36%) with subcostal, with four (9.09%) with transrectal, at two (4.55%) with pararectal laparotomia, in two (4,55%) patients after lumbotomia made with two (4,55%) after Phanensthil incision. The treatment of the anterior abdominal wall hernia in 72 (67.21%) patients, we used prolen net, while in 35 (32.79%) patients made plastic abdominal wall. Drainage was used in 62 (57.94%) operated patients. In 78 (72.90%) patients applied the prophylactic dose of antibiotics, while in 29 (27.10%) patients applied therapeutic dose. The length of treatment of patients who applied prophylactic dose of antibiotics was 2.48 days and length of treatment of patients with therapeutic dose applied was 4.82 days. Prospective studies of patients in the postoperative complications are recorded in four (3.74%) patients. We had wound infection in two (1.87%) and recidive hernia in two (1.87%) patients. Conclusion: This surgical method, when it comes to herniotomia, a direct comparison with the number of postoperative recurrence. Implantation of mesh has found its place and it is a revelation in the resolution of abdominal wall hernia.

Vital extirpation is microsurgical intervention.Wellknowing of internal morpfology of pulp cavity and with patience, carefull and precise work is possible to extirpate, dilatate and fil in both distal and mesial root of down molars,even if in mesial root exists two canal (buccal and lingual) what is the ruosh aften finding. Vital extirpation is very frequenthy used method in the treatment of multi-root teeth.It is more requested intervention tlak usnal once,but patients mane less visits at the dentist and the results one good enongh. So, one session method isacceptable as from medical point of view but endodontic too.

Intussusception is a specific type of delay in the bowel passage which according to frequency, clearly takes place in children's abdominal surgical pathology. Most commonly occurs in children during the first year of life and from 6 and 9 months where the 3 diagnosed in boys than girls 2. The incidence is 1-4 per 1000 live-born children. The most common form of invagination is ileocecala (80%), ileocolic, and ileo-ileal colo-colic. Intussusception is most often idiopathic (almost 90%) cases, while in a very small percentage described the existence pathoanathomic substrate (points leaders), which areusually enlarged lymph nodes or Meckel divertikulum. Surgical therapy for these other groups is much more radical. For a period of 6 years (2003-2009), which we cover the work, the children’s surgery of the Health Center Novi Pazar was treated with 22 children diagnosed with invagination (intussusception). Of this number, there were 14 (63.63%) boys, 8 girls (36.36%), and the average number of cases was 4.44 per year. Frequently appeared ileo-cecal and ileo-ileal (90.63%), while colocolic and ileocolic appeared much less (9.09%). The most common clinical symptoms were the presence of fresh blood in the stool, painful cramps and, vomiting who did the dominant clinical presentation in the majority. Following: fever, malaise, and even convulsions. The conclusion is: triad of symptoms (pain, vomiting and blood in the stool in the form "of currant jelly") were pathognomonic diagnosis. The method of choice in the diagnosis and conservative therapy is the initial hydrostatic desinvagination controlled ultrasound.

Planocellular carcinomas grow rapidly infiltrating the surrounding tissues. Because of that approach to the treatment of the patients must be multidisciplinary. A series of 101 patients with tongue and mouth floor carcinoma were analyzed. All were surgically treated in the period 2000. through 2007. The clinically evidenced local spread (cT) is highly correlated to the intraoperatively and patohistologically evidenced spread (pT) ~84%. The degree of correlation falls with increase of the T stage. The clinically evidenced regional spread (cN) and intraoperatively and patohistologically evidenced of regional spread (pN) presented lower in ~57% correlation then corresponding T categories. The study proves that multidisciplinary approach to the patients with oral carcinomas is the base for their proper treatment. 

Objective: To study the clinical profile of patients admitted with polytrauma over a five year period in a general hospital and review the management of abdominal trauma in them. Material and Methods: Medical records of 92 patients were studied retrospectively. The clinical presentation with details of injuries, relevant investigations done and the operative findings were analyzed. Results: Polytrauma was significantnly more common in males than females (P<0.001) and more so in the young age, between 20 and 29 years of age ( P<0.01). Road Traffic Accidents were the predominant cause followed by falls. Surgical operative management was necessary in 38 patients (41%) with abdominal trauma. Overall mortalitety was 4%, that for admitted patients 1% and post-operative mortality 3%. Conclusion: The clinical profile of polytrauma and the management of abdominal trauma in a general hospital are presented. The need for updating the national trauma registry with uniformity in reporting polytrauma in Serbia. 

Cancer diseases of female genital system emerge as a result of continues influence of risk factors and heritage base. Commonly accepted risk factors are viruses, sexual intercourses without protection, early sexual relations- where the contact in the period under age 18 is highly risk, smoking (consumption of tobacco) and promiscuities males. Beside mentioned risk factors, we are exploring whether the life conditions and chronically stress are specific risk factors for isolated community. Serbian community in area of central Kosovo counts around 10.000 women in reproductive and menopausal stage. In the period of last 10 years, this specific community was exposed to the aftermaths of Nato aggression in 1999, meaning bombardment with uranium ammunition, poor conditions, refugee exile and return, chronically stress, period without adequate health protection and permanent feeling of life in hostile environment. The results were catastrophic : 5 invasive carcinomas of cervix in female in postmenopausal (56, 71, 50, 76, 54, years of age), 1 squamocellulare carcinoma of vagina (76 years of age) and one squamocellulare carcinoma of vulvae (57 years of age), both in postmenopausal period. In reproductive stage in 3 female H SIL was diagnosed (36, 42, 31 years of age). In three cases, as result of explorative curettage adeno cancer of endometrium was diagnosed (72, 66, 64 years of age).

Basic features of spiral scanners are described, and constructive features of multislace devices are described in detail.Basic principles of functioning and detector number of multislace scanners are described, particularly in 64 layered devices.A short survey of device construction and received X-ray dose during examination is presented. Diagnostic possibilities and multislace scanner application according to organs and organ systems, as well as their advantages in relation to sequential and spiral scanners, are presented.

In this review paper, metabolism of most used inhaled halogenated anesthetics (halothane, enflurane, isoflurane, desulfurane and sevoflurane) is shown Only part of the anesthetics is metabolized, while the remainder is eliminated unchanged. They are metabolized by mixed function oxidases (reductive or oxidative pathways). 

Because of it’s anabolic and lipolytic effects and with the beginnings of the production of recombinant growth hormone for the treatment of many congenital diseases began and growth hormone abuse in sport. His contributions to enhancing the physical performances of athletes are debatable, and there are many side effects. Detection of growth hormone use as doping agents is impossible by standard means of doping because of the identity of its recombinant and natural forms. There are various tests measuring its isoforms and collagen peptide, while the use of carbon isotope is still under investigation. Efficient detection tests, the use of "athlete passport" and education of athletes, are good way to prevent misuse of growth hormone.

Introduction: Most permanent teeth erupt and establish proper occlusion. In some cases, the permanent teeth have a problem in the eruption and remain impacted in bone.There are two possibilities. 1. Extraction of impacted tooth and its replacement implant or a prosthetic replacement, 2. Surgical release of the impacted teeth and orthodontic traction in the dental arch. The time of treatment, type of surgery release impacted teeth, orthodontic techniques and possible problems during treatment, depending on the type of the impacted tooth and its location. Case report: Clinical examination 14-year-old patients concluded the lack of maxillary canine teeth in the dental arch. Panoramic image showed bilateral canine impaction in the upper jaw. The analysis of X-ray image was recorded axial and in the middle alveolar position of both the impacted tooth. This is why we chose the of closed eruption method. Discussion: Impacted maxillary canines, the middle alveolar ridge treated by closed eruption, except for a slight increase in clinical crown of the tooth does not show other changes deteriorate.

Gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract. Anatomic locations, in decreasing, are: stomach (60%), small intestine (30%), colon and rectum (5%), oesophagus (5%). Histogenesis is still unclear, criteria of malignancies are not adapted, biological behavior in not known, and the diagnosis and prognosis are questionaly. Although usually asymptomatic, large gastrointestinal stromal tumor may present with repeated bleeding. Most often diagnosis in mode during the explorative laparotomy and postoperative immunohistochemical analysis of specimen. In this paper we have analized patients with gastrointestinal stromal tumors of the oesophagus. The patient preoperatively diagnosed submucosal tumor of the esophagus presented with repeated gastrointestinal bleeding. After the resuscitation, we performed total gastrectomy. The immunohistochemical analysis proved benign GIST. Surgical resection is a treatment of choice gastrointestinal stromal tumors presented with gastrointestinal bleeding. 

Aim: There is a few data in the literature on the medical significance of Mesobuthus gibbosus whose sting is considered potentially hazardous for human health. In this case two patients in the age of 16 and 25 with diagnosed scorpionism Mesobuthus gibbosus are described.Here is the example of woman 49 years old who had scorpionism, Euscorpius italicus. Case report: The stings by Mesobuthus gibbosus in both cases occurred during the construction work done by tourists. The following general symptomes were noticed: excitement, pulsating pains, muscle cramps in legs, pallor and profuse sweating. Local symptoms were: paresthesis, bruised skin, erythematous swelling with a red spot in the centre.After two years one patient had occasional muscle twitching, extension of superficial vein and pain on her injured leg. Sting by Euscorpius italicus happened in a bathroom while doing her physiological needs. The local symptoms were: swelling, redness and pain. The general symptoms were: numbness of a neck, intensive salivation and nausea. The symptomatic therapy was implemented in all three cases and was successful. Conclusions: Mesobuthus gibbosus and Euscorpius italicus can be found at the Montenegrian coast and represents a real danger for the health of the local community and tourists. Therapy of these scorpionism is only symptomatic.

Treatment, rehabilitation and aesthetics should be the main tasks of modern dentistry. Adequate prosthetic therapy and rehabilitation may be conditioned by different factors. The paper describes prosthetic rehabilitation of a patient, 55 years old woman, with abnormalities in the vertical dimension of occlusion and malocclusion of the third class, and all in order to return of aesthetics and the function of stomatognathic system. The patient came to the clinic due to disturbed aesthetics and function, where was achieved the appropriate amount of bite along with satisfactory aesthetics and functional results due to a combination of fixed and partial dentures. Two metal-ceramic bridges consisted of 13 pieces were built in the upper jaw, and 8 teeth mobile partial denture in lower jaw, thus resulting in satisfactory requirements set to re-establish aesthetics and function of stomatognathic system. 

Epstein-Barrov virus (EBV) is a cause of heterophile antibody positive infectious mononucleosis (IM),which is characterized by fever, sore throat, limfadenopatiom and atypical limfocitozom. IM is mainly a self-limited disease. Complications of the central nervous system, hepatitis (which can be fulminant), (splenomegalia, obstruction of the upper respiratory tract with bacterial can sometimes be deadly.