METABOLISM AND INHALED ANESTHETIC ELIMINATION

J. Plačkić ,
J. Plačkić

Department of Chemistry, Faculty of Science, University of Novi Sad , Novi Sad , Serbia

Lj. Gvozdenović ,
Lj. Gvozdenović

Institute of Surgery, Clinic of Anesthesiology and Critical Care Medicine, Clinical Center of Vojvodina , Novi Sad , Serbia

M. Vojnović ,
M. Vojnović

The Health Center , Novi Sad , Serbia

M. Popović ,
M. Popović

Department of Chemistry, Faculty of Science, University of Novi Sad , Novi Sad , Serbia

R. Mitić
R. Mitić

Faculty of Medicine Pristina , Kosovska Mitrovica , Kosovo*

Published: 01.12.2010.

Volume 38, Issue 2 (2010)

pp. 133-136;

https://doi.org/10.70949/pramed201002380P

Abstract

In this review paper, metabolism of most used inhaled halogenated anesthetics (halothane, enflurane, isoflurane, desulfurane and sevoflurane) is shown Only part of the anesthetics is metabolized, while the remainder is eliminated unchanged. They are metabolized by mixed function oxidases (reductive or oxidative pathways). 

Keywords

References

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Varagiæ V, Miloševiæ M. Farmakologija.
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Spracklin DK, Hankins DC, Fisher JM, Thummel KE, Kharasch ED. Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. J Pharmacol Exp Ther. 281(1):400–11.
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Reichle FM, Conzen PF. Halogenated inhalational anesthetics. Best Practice & Research Clinical Anaesthesiology. 7:29–46.

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