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THE EFFECT AND INTERACTION ASPIRIN AND TICLOPIDINE ON HEMATOLOGICAL VARIABLES IN RATS
Institute of Pharmacology and Toxicology, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute of Pharmacology and Toxicology, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute of Physiology, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Department of mathematics, Faculty of Natural Sciences and mathematics Pristina , Kosovska Mitrovica , Kosovo*
Institute of Pharmacology and Toxicology, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Published: 01.12.2010.
Volume 38, Issue 2 (2010)
pp. 9-13;
Abstract
The combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting, but also can cause serious hematological side effects. The purpose of this study was to evaluate the effect and interactions aspirin and ticlopidine on hematological variables. Thirty two Wistar rats were divided in four groups and they received intraperitoneal one of the following treatments for 4 days: group I - control, group II aspirin (50 mg/kg BM), group III - ticlopidine (125 mg/kg/day) and group IV - aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day). Hematological variables were determined at once after taking the sample of blood. Relationship between measured variables was determined by calculating linear correlation coefficient (r). The hematocrit, haemoglobin and red blood cell were significantly decreased in group treated with aspirin+ticlopidine combination compared to control (p< 0,05). Neutrophil and platelet count weren't significantly different in treated groups, but were slightly decreased in groups treated with ticlopidine and aspirin+ticlopidine combination. Between hematocrit and platelet count in control group of rats was noticed negative and medium correlation (r=-0,41), in groups treated with ticlopidine and aspirin+ticlopidine combination positive and medium correlation (r=0,52; r=0,69). Based on obtained results it can be observed significant decreased hematocrit, haemoglobin and red blood cell in group treated with aspirin+ticlopidine combination. The negative correlation between hematocrit and platelet count in control group becomes positive after the treatment with ticlopidine alone and aspirin+ticlopidine combination.
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