Zastupljenost faktora aterogeneze kod pacijenata sa moždanim infarktima prednje i zadnje granične vaskularizacione oblasti

V. Mitrović ,
V. Mitrović
S. Filipović Danić ,
S. Filipović Danić
B. Biševac ,
B. Biševac
R. Stolić ,
R. Stolić
M. Šipić
M. Šipić

Published: 15.01.2014.

Volume 42, Issue 2 (2013)

pp. 19-21;

Abstract

Aterogeneza je postepen proces koji započinje u ranom životnom periodu, odvija se lagano, decenijama i može biti prepoznat tek kada se razviju infarkt srca, mozga ili periferna vaskularna bolest. Cilj istraživanja bio je da se utvrdi učestalost i zastupljenost faktora aterogeneze kod pacijenata sa moždanim infarktima u graničnoj supratentorijalnoj arterijskoj distribuciji. Istraživanje je sprovedeno u sedmogodišnem periodu, kod 30 bolesnika, kao prospektivna studija. Kao faktori aterogeneze definsisani su pacijenti sa kardiovaskularnim oboljenjima, dijabetes mellitusom i pušači, a kod svih ispitanika verifikovana je koncentracija holesterola. U grupi ispitanika sa infarktom moždanog tkiva u prednjim partijama, u odnosu na bolesnike sa moždanim infarktom u zadnjim partijama, utvrđen je statistički značajno veći broj bolesnika sa kardiovaskularnim bolestima (p=0,025). Grupa pacijenata kod kojih je utvrđen infarkt moždanog tkiva u prednjim partijama imaju značajno veći broj bolesnika sa diabetes mellitusom (p=0,023), veći broj pušača (p=0,021), a utvrđena je i statistički značajno veća koncentracija holesterola (p<0,0001). Pacijenti sa prednjim moždanim infarktom imaju statistički značajno veći aterogeni potencijal.

Keywords

References

1.
Alexander RW. Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: A new perspective. *Hypertension*. 1995;25(2):155–61.
2.
Association AH. *Heart and Stroke facts: 1994, Statistical Supplement*. 1994.
3.
Dyken ML. Risk factors predisposing to stroke. In: *Surgery for cerebrovascular diseases*. 1996. p. 33–42.
4.
Group ECSTC. Randomised trial of carotid endarterectomy for recently symptomatic stenosis: Final results of the MRC European Carotid Surgery Trial (ESCT. *Lancet*. 1998;351:1379–87.
5.
Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. *Stroke; a journal of cerebral circulation*. 2011;42(2):517–84.
6.
Grundy SM, Balady GJ, Criqui MH, Fletcher G, Greenland P, Hiratzka LF, et al. Primary prevention of coronary heart disease: guidance from Framingham: a statement for healthcare professionals from the AHA Task Force on Risk Reduction. *Circulation*. 1998;97(18):1876–87.
7.
Mancia G. Optimal control of blood pressure in patients with diabetes reduces the incidence of macro and microvascular events. *Journal of Hypertension*. 2007;25(Suppl 1):7–12.
8.
O’Regan C, Wu P, Arora P, Perri D, Mills EJ. Statin Therapy in Stroke Prevention: A Meta-analysis Involving 121,000 Patients. *American Journal of Medicine*. 2008;121(1):24–33.
9.
Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. *Nature*. 1993;362(6423):801–9.
10.
Whincup PH, Gilg JA, Emberson JR, Jarvis MJ, Feyerabend C, Bryant A, et al. Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement. *BMJ (Clinical Research Ed)*. 2004;329(7459):200–5.

Citation

Copyright

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Most read articles

Indexed by