The use of antibiotics and their influence on course and outcome of bacterial meningitis in children before diagnosing it

D. Odalovic ,
D. Odalovic
M. Cukalovic ,
M. Cukalovic
N. Ikatanic ,
N. Ikatanic
A. Odalovic
A. Odalovic

Published: 01.12.2013.

Volume 43, Issue 2 (2014)

pp. 15-19;

https://doi.org/10.5937/pramed1402015o

Abstract

Bacterial meningitis is a severe infective disease caused by different bacteria during which purulent pyorrhea is created in a subarachnoid space. In clinical terms, it is represented with the appearance of meningeal symptoms and signs. Neither recent years’ success accomplished in treatment of bacterial meningitis nor the best organized treatment provide an optimistic prognosis in sick children. Our research was conducted in 91 children with bacterial meningitis. Before diagnosing bacterial meningitis, 50 patients ( 54.9 % ) were treated with antibiotic therapy. In this group, 21 patients ( 42% ) showed complications in disease manifested with convulsions in 13 patients (26 % ). In the same group, 29 patients ( 58 % ) had a complete recovery after the treatment while 8 patients ( 16 % ) had sequele. In 41 patients ( 45 % ) without previous antibiotic treatment, complications are registered in 25 patients ( 60.9 % ) as follows: 18 patients ( 43.9 % ) had early complications while 7 patients ( 17.1 % ) had sequele. 16 patients ( 39 % ) had a complete recovery in this group. Complications and sequele are more common in the group of sick children without antibiotic therapy before diagnosing bacterial meningitis. However, the presence of sequele in the group of children which were treated with antibiotics before completed diagnostics showed that treatment of bacterial meningitis must be done in a more effective way as well as an early antibiotics treatment.

Keywords

References

1.
Marjanović B. 2005;231–45.
2.
Dimitrijević N. Bakterijski meningitis-epidemiologija i patofiziologija, Zbornik radova, 42. Pedijatrijski dani. 2009;123–4.
3.
Chang C, Chang W, Huang L, Huang S. Bacterial meningitis in infants: the epidemiology, clinical features, and prognostic factors. Ann Epidemiol. 2004;(1):44–8.
4.
Odalović D. Bakterijski meningitis salmonelozne etiologije u dece. Praxis medica N. 2004;(4):15–9.
5.
Scheld W, Koedel U, Nathan B. Pathophysiology of bacterial meningitis: Mechanism of neuronal onjury. I. Infect Dis. 2002;(Suppl 2):225-S233.
6.
Sunakawa K, Ubukata K, Chiba N, Hasgawa K, Nonoyama M, Iwata S, et al. Childood bacterial meningitis. Kansenshogaku Zasshi. 2008;(3):187–97.
7.
Nigrovic L, Kuppermann N, Macias C. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. Jama. 2007;52–60.
8.
Odalović D, Mitić N. Clinical-Morphological aspect of the bacterial meningitis in children. :184.
9.
Kaster-Rasmussen R, Korshin A, Meyer C. Antibiotic treatment delay and outcome in acute bacterial meningitis. J Infect. 2008;(6):449–54.
10.
Johnson W, Adedovin O, Abdulkarim A, Olanrewaju W. Bacterial pathogens and outcome determinants of childood pyogenic meningitis in LLorin, Nigeria. J Med Med Sci. 2001;(4):295–303.
11.
Marjanović B, Pavlović M, Janković B, Abinun M, Pašić S. 1995;171–84.
12.
Swartz M. Bacterial meningitis-A view of the past 90 years. N Engl J Med. 2004;
13.
Marjanović B, Vlajić B, Ignjatović M. Novine u lečenju bakterijskog meningitisa u dece. U: Marjanović B, urednik. Problemi u pedijatriji 88. Naučna knjiga. 1989;16–33.
14.
Blazer S, Berant M, Alon U. Bacterial meningitis: Efect of antibiotic treatment on cerebrospinal fluid. J Clin Pathol. 1983;386–7.
15.
Mongelluzzo J, Mohamad Z, Have T, Shah T, S. Corticosteroids and mortality in children with bacterial meningitis: Jama. 2008;(17):2048–55.
16.
Kilpi T, Anttila M, Kallio M. Lengrh of prediagnostic history related to the course and sequele of childhood bacterial meningitis. Pediatr Infect Dis J. 1993;184–8.
17.
Mcinture P, Macintyre C, Gilmour R. A population based study of the impact of corticosteroid therapy and delayed diagnosis on the outcome of childhood pneumococcal meningitis. Arch Dis Child. 2005;391–6.
18.
Odalović D, Čukalović M, Perić M, Odalović A. Komplikacije I sekvele bakterijskog meningitisa u dečjem uzrastu. Praxis medica. 2010;(4):71–5.
19.
Obradović S. Bakterijski meningitis u dečjem uzrastu. Zbornik radova. 42. Pedijatrijski dani. 2009;125–6.

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