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EFFECTS OF DIFFERENT DOSES OF ZINC PREPARATION ON GLYCEMIA AND ANTIOXIDANT PARAMETERS IN EXPERIMENTALLY INDUCED DIABETIC RABBITS
Institute of Pharmacology and Toxicology, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Pharmacology and Toxicology, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Biochemical-Clinical Laboratory, Health Center Kosovska Mitrovica , Kosovska Mitrovica , Kosovo*
Institute of Physiology, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Department of mathematics, Faculty of Natural Sciences and mathematics Priština , Kosovska Mitrovica , Kosovo*
Institute of Pharmacology and Toxicology, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Physiology, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Published: 01.01.2011.
Volume 39, Issue 1 (2011)
pp. 27-31;
Abstract
Researches with micronutrients are getting more and more important in science and also in practice. In this view zinc, chromium, copper and selenium are having a special role in preventing micro- and macrovascular diabetic complications, as integral components of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and also as cofactor of enzymes and hormones involved in the metabolism of glucose and lipid. The aim of this study was to evaluate the effects different doses of zinc on glycemia and parameters of antioxidative defense: superoxide dismutase (SOD) and total antioxidant status (TAS), and correlation glycoregulation with antioxidant system of the alloxan-induced diabetic rabbits. The study was conducted on fourteen New Zealand rabbits of both sexes, weighing 2 to 3.5 kg. Experimental diabetes was induced in rabbits by intravenous injection of alloxan (80 mg /kg BW). Three weeks after induced experimental diabetes, rabbits were treated orally appropriate doses of chelated zinc: I dose - 15 mg, after a washout period (10 t ), II dose - 25 mg, af- 1/2 ter a washout period, III dose - 50 mg. Blood samples were taken at specific time intervals: before alloxan induced diabetes, after alloxan induced diabetes, after application the first dose of 15 mg of zinc, after application of a second dose of 25 mg of zinc, after application of third dose of 50 mg of zinc. The zinc preparation did not cause a statistically significant reduction in serum glucose level when administered in single doses 15, 25 and 50 mg in experimentally induced diabetic rabbits. However, the activity of superoxide dismutase (SOD) was significantly increased after single dose preparations of zinc at a dose 15 mg (p<0,05), 25 mg (p<0,001) and 50 mg (p<0,001) in relation to the activity recorded before the application of zinc. Also, after the application first, second, and than third dose of zinc in diabetic rabbits was recorded statistically significant increase of TAS in relation to the value recorded before the application of zinc (p<0,001). Glucose concentrations negatively correlated with superoxide dismutase activity. This indicates that oral application of zinc preparation can reduce the harmful effects of oxidative stress in diabetes.
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