Aging as continous biological process, affect all organic systems. Aging is believed to affect the structure and function of the enteric nervous system. Prymary aim these studies is to verify changes in number of neurons in myenteric nervous plexus of human stomach within relation to process of aging. In the course of research played is analysis number of neurons in myenteric nervous plexus of anterior wall stomach. Analysis was performed within 30 tissue samples which are classified into three age groups: (from 20 to 44 years, from 45 to 64 years and over 65 to 84 year old). Played is histological processing and stained with HE, Cresyl-violet, AgNO3 and AChE methods. The morphometric measures operated by morphometric multipurpose test system M42. Finding results are statistically processed by Student-t-test and analysis of variance. Discernible is very heavy loss of neurons of myenteric plexus within the oldest group in relation to younger groups. Applied test show are having statistically notable variance between age groups. In percentage, the loss of neurons in the oldest group in relation to others was from 13,81% to 15,44%.

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