Poremećaj podnošenja proteina kravljeg mleka se javlja kod 2-6% dece, uglavnom u dojenačkoj dobi. Cilj rada je bio da se prikažu iskustva i zapažanja u vezi sa kliničkim simptomima i znacima nepodnošenja proteina kravljeg mleka kod odojčadi. U istraživanje je bilo uključeno 121 odojče kod kojih je nepodnošenje proteina kravljeg mleka dijagnostikovano u uzrastu od petnaest dana do devet meseci. U kliničkoj prezentaciji nepodnošenja proteina kravljeg mleka dominirale su kutane smetnje, koje su utvrđene kod 88 bolesnika (72,72%), potom digestivne smetnje, zabeležene kod 68 odojčeta (56,20%), dok su respiracione tegobe bile najređe (14,87%). Ni kod jednog ispitanika nije zabeležen anafilaktički šok. Rezultati istraživanja pokazuju da u poremećaju podnošenja proteina kravljeg mleka kod odojčadi preovlađuju kutane i kutano-digestivne smetnje, dok su respiracione tegobe relativno retke.

Peripartalna kardiomiopatija (PPKM) je redak poremećaj srčane slabosti nepoznatog uzroka koji je često fatalan za mlade žene. Javlja u kasnoj trudnoći ili postpartalnom periodu. PPKM može biti teško dijagnostikovati jer simptomi srčane slabosti mogu imitirati one simptome koji se inače javljaju u trudnoći. Prikaz bolesnika,29- godišnja žena, u 38 nedelji gestacije primljena je na odeljenje zbog otežanog disanja, zamora pri minimalnom naporu i osećaja ubrzanog lupanja srca. Na prijemu bleda, lako oznojena i dispnoična, blede kože i vidljivih sluznica. Gojazna. Auskultacijom na plućima bazalno obostrano oslabljen disajni šum uz inspirijumske pukote bazalno desno. Akcija srca je tahikardna (135 /min) , tonovi oslabljeni, ritam galopa, sistolni šum na ictusu 3/6 po Levinu. TA 130/90. Abdomen je iznad ravni g. koša, inspekcijom se uočavaju gravidarne strije. Ekstremiteti bez edema. Elektrokardiogram pokazuje sinusnu tahikardiju sa fr 130/min, pQ 0,10 sec,qr u D3, slaba progresija r zubca od V1-V4, bifazan p talas u V1, povremene VES, nema značajnih ST-T promena. Odmah urađena transtorakalna ehokardiografija (TTE) pokazala je levi ventrikul uvećanih enddijastolnih i endsistolnih dimenzija (EDDLV 82mm, ESDLV 72 mm), uredne debljine zidova, sa globalnom hikpokinezijom i bez regionalnih ispada u kinetici, sa sniženom EF koja je procenjena na oko 25-30%. Tretirana kardiotonicima, diureticima, uz suspstituciju kalijuma, i Antagonistima kalcijuma što dovodi do poboljšanja stanja. Nakon 5 dana trudnoća je završena carskim rezom i rođeno je zdravo žensko dete. Zaključak: Peripartalna kardiomiopatija je oboljenje čija je etologija još uvek nedovoljno rasvetljena, i na na našim prostorima nije tako česta, ali neblagovremena ili zakasnela dijagnoza su fatalni za trudnicu.

Copper is an essential element, a constituent of all living cells and an integral component of many enzymes. The increase in pollution of the environment, and various metabolic diseases, imbalances biological processes and homeostatic regulated content of bioelements in the body. For the purpose of determining changes in the contents of bioelements with increased intake of copper, the paper followed by interaction before and after ingestion of copper. The results showed that copper in excess causes disruption of physiological interactions of bioelements in tissues and significantly increases the content of iron and magnesium. The nature and relationships of these interactions are important, because in terms of exposure to metals, there are changes in their mutual relations, with some of these antagonistic relationships may be utilized for further study in order to protect them from toxicity.

Rheumatoid arthritis is a chronic multisistemic disease of an unknown cause characterised by persistens inflammatory synovitis which results in destruction cartilage and bone erosions. RA is a systemic disease with various out of joint manifestations of different clinical importance, among which rheumatoid knots, rheumatoid vasculitis, pleuropulmonal and ophthalmological manifestations are the most prominent ones. The most frequent changes of the eye in patients with RA are keratoconjunctivitis sicca (KCS), episcleritis and scleritis and ulcerous keratitis. Out of 70 examined patients, 52 (74.3%) are female, and 18 (25.7%) of male sex (ratio 4:1), average age 56.47. In 18 (25.71%) RA diseased patients eye changes found are as folows: secondary Sjögren syndrom, that is keratoconjunctvitis sicca in 18.57%, only in female patients, episcleritis nodosa and scleritis in 4.29%; 2.86% in male and 1.43% female patients and ulcerous keratitis in 2.86% RA diseased patients. 

In our work we analyzed utilisation of antibiotics for systemic use at the Surgical Clinic of the Clinical Hospital Centre - Pristina in Gracanica in 2007. and 2008. Data on antibiotic utilization were delivered on the basis of drug dispensing records from the Central Hospital Pharmacy during the two-years period. Antibiotics were distributed inside the ATC/DDD system in accordance with WHO guidelines. Quantitative antibiotics' utilisation was expressed as number of defined daily doses per 100 patient-days (DDDs/100 PD). Overall use of antibiotics in 2007 was 123.37 DDDs/100 PD, and 125.09 DDDs /100 PD in 2008. Three most utilized antibiotics in 2007. were cefuroxime 24.26 DDDs/100 PD (19.66 % of total antibiotics' use), ceftriaxone 16.65 DDDs/100 PD (13.49 %), and cephalexin 15.78 DDDs/100 PD (12.79 %). In 2008. the most utilized were ceftriaxone 23.23 DDDs/100 PD (18.57 %), cefuroxime 22.53 DDDs/100 PD (18.01 %), and co-trimoxazole 19,55 DDDs/100 PD (15.63 %). Qualitative and quantitative part of the consumed antibiotics was mainly in accordance with the results of similar researches in our country.

In the last ten years significant progress has been made in understanding of role of neutrophil granulocytes and their enzyme myeloperoxidase in the evolution and complications of atherosclerosis. Myeloperoxidase plays the role in the development of vulnerable plaque associated with the development of acute coronary syndrome. There is much evidence that suggests the role of myeloperoxidase in the development of vulnerable plaque. We investigate the value of myeloperoxidase as marker of the presence of vulnerable plaques in patients with acute coronary syndrome. Myeloperoxidase activity was significantly high in serum of the patients with the diagnosis of acute coronary syndrome as reflection of the presence of vulnerable plaques. Increase in myeloperoxidase activity in serum of patients with the diagnosis of acute coronary syndrome precedes to myocardial damage.

Even 1000 years BC the famous Persian physician Aviccena describet the first time gangrene diabetes mellitus as a complication. Basic pathohistological substrate vascular complication is atherosclerotic plaqueand therefore is an adequate treatment opf patients with vascular disease is conditioned by timely and precise diagnosis.The introduction of ultrasound technology in clinical practice enabled Edler and Hertz when the shou moves infarction 1954th,a then and Yoshida (1956.) and Sotomura (1959.), Frenklin (1961.) who are using ultrasound display of blood flow in the courts of man. The aim of our study was to deterimne the frequency of occurrences of atherosclerotic plaque in the carotid arteries and ultrasound examination of differences in the variability of certain plaques between patients with diabetes mellitus type 2 and healthy subjects. The examination was attended by a total of 82 people divided into two group. In first group they are 51 persons suffering from diabetes mellitus type 2 in to second control, the number of healthy respondents was 31. Among our respondents, a significantly higher incidence and plaque vulnerability was ina group of patients with diabetes mellitus type 2. 

In diabetics fungal skin infections are reported to be related to greatly disturbed metabolism. In order to get better insight into the association between diabetes mellitus and fungal skin infections, we started our study with the aim to assess the effect of metabolic regulation on the incidence of fungal skin infections is diabetics. The obtained results of our study show that in patient with metabolically poorly regulated primary disease i.e. diabetes the incidence of the fungal skin infections is highest (36.0%), its incidence is lower in patients with metabolically satisfactorily regulated diabetes (29.5%) and lowest in those with well regulated diabetes (18.8%), witch is statistically significant difference (p=0.045).

Endometrial hyperplasia appears like a result of continues, not mortified stimulation of endometrial by estrogenically hormones. Endometrial becomes nub which histological mirrors in endometrial gland multiplication, in smaller amount even endometrial strom. Endometrial polyp represents focal overmuch growth of gland stromas endometrial and its considered a focal endometrial hyperplasia. Therefore we will examine them at the same time. Medical faculty of Prishtina - Kosovska Mitrovica did an analysis of biopsy and operational material in pathology institute in the period from 2005 to 2008 out of 3696 histological proved cases, its recorded that 210 cases have endometrial hyperplasia and endometrial polyp, which is 5,68%. According histological type the most often seen is endometrii hyperplasia simplex who is spotted in 127 cases (60,48% - D= 0,195; p<0,001), endometrii hyperplasia complex in 19 cases (9,09%), cases where endometrial hyper-plasia and endometrial polyps are united are spotted in 14 cases (6,67%), while endometrii polypus in 50 cases (23,81%). By analysis of all types of endometrial hyperplasia and endometrial polyps we came to conclusion that all of these changes are mostly made at the age of 41-50 (60,48%) compared to other ages. (D=0,267; p<0,001). In between all patients the youngest was 22 years old (endometrii hyperplasia simplex) and the oldest 78 years old (endometrii polypus). On the basics of studied values, regression's analysis it's been confirmed that the numbers of cases with endometrial hyperplasia and endometrial polyps are growing for 8,6 every year, which points at bigger and bigger problem in the whole pathology.

This article aims to promulgate the use of Microsoft Excel, one of the predominant spreadsheet applications, in the calculation of approximate functions by the method of spline polynomial interpolation. Cubic spline functions have demonstrated a remarkable suitability for the analysis of pharmacokinetic data of drugs with non-linear kinetic behavior or an unknown kinetic model, as well as general kinetic analysis, regardless of pharmacokinetic and compartmental models. It should be noted that cubic spline polynomials can be employed in determining a highly significant pharmacokinetic parameter - the area under curve (AUC), especially when the area measurement is not the principal intention, and the data is to be used for further research. Spreadsheet software is exceptionally pertinent to this kind of computation, as it delivers high precision and virtually instantaneous availability of the results. Moreover, this type of software possesses conspicuous flexibility, characterized by a real-time graphical representation and the capability to sustain user-created functions through a macro-language (VBA - Visual Basic for Applications) implemented in the program itself.