EFFECT OF ACUTE POISONING WITH ORGANOPHOSPHATE COMPOUNDS ON HYDROELECTROLITIC AND ACIDE-BASE STATUS OF CHILDREN'S

J. Drmončić-Putica ,
J. Drmončić-Putica

Children's clinic, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

J. Živković
J. Živković

Children's clinic, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

Published: 01.01.2011.

Volume 39, Issue 1 (2011)

pp. 47-50;

https://doi.org/10.70949/pramed201101396D

Abstract

Acute organophosphate (ÎÐ) poisoning is an important cause of morbidity and mortality in children especially in the developing countries. Published studies work have been reported on acute childhood poisoning has focused mainly on the epidemiological trends, with little information about alteration in electrolitic and acid-base equilibrium and other disturbance and on the management of the poisoned children. Hypovolaemia, electrolyte derangements and acidosis are major predisposing factors for development of complications. Metabolic acidosis is one of the major causes of death in patients poisoned with OPC acutely. We suggest that children's with acute OPC poisoning should be screened for electrolyte and metabolic acidosis with blood gas analysis.

Keywords

References

1.
Asari Y, Kamijyo Y, Soma K. Changes in the hemodynamic state of patients with acute lethal organophosphate poisoning. Vet Hum Toxicol. 46(1):5–8.
2.
Balali-Mood M, Ayati MH, Ali-Akbarian H. Effect of high doses of sodium bicarbonate in acute organophosphorous pesticide poisoning. Clin Toxicol. 43:571–4.
3.
Eskenazi B, Bradman A, Castorina R. Exposure of children to organophosphates and their adverse health effects. Environ Health Perspect. 107(3):409–19.
4.
Liu JH, Chou CY, Liu YL, Liao PY. Acid-base interpretation as a predictor of outcome among patients with acute organophosphate poisoning before hospitalization. Am J Emerg Med. 26:24–30.
5.
Toksikologija JM. Elit.
6.
Rotenberg SJ, Newmark J. Nerve agent attacks on children: diagnosis and management. Pediatrics. 112(3):648–58.
7.
Saadeh AM, Farsakh NA. Cardiac manifestations of acute organophosphate and carbamate poisoning. Heart. 77(5):461–4.
8.
Seltur R, Sharma RM. Severe metabolic acidosis secondary to organophosphate poisoning. Anesth Analg. 101(1894).
9.
Stefanović D, Antonijević B, Bokonjić D, Stojiljković PM, Milovanović AZ, Nedeljković M. Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. Basic Clin Pharmacol Toxicol. 98:173–88.
10.
Sungur M, Güngör M. Intensive care management of insecticide poisoning. Crit Care. 5:211–5.

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