Arachnoid cysts are cavities filled with liquor, usually localized on the floor of the middle cranial fossa. Clinically, they are usually asymptomaticand can sometimes be presented with increased intracranial pressure syndrome and epileptic seizures. We present a patient who, after a slight head injury in a accident develops an increased intracranial pressure syndrome followed by an epileptic seizure. Based on the clinical course and diagnostic processing, we want to draw attention doctors who are in a position to inspect these patients that apparently slight head injuries can be complicated and dangerous for the lives of the premorbid intracranial condition of the injured.

Melanoma is the most aggressive skin cancer that has a tendency of early lymphatic and hematogenous metastasis. Surgical excision constitutes as a methods of treatment. Early diagnosis is the key to successful treatment of melanoma, which is primarily associated with Breslow and Clark grading. The aim of this study was to investigate these and other prognostic parameters such as the age, the gender and the anatomical distribution of melanoma, macroscopic and histological type of melanoma, the size and the remains of the tumor tissue at the surgical margins. We analysed biopsy material of Institute of Pathology, Faculty of Medicine in Pristina from 2004 to 2017. year. We found that melanoma were more common at older men (average age of 68.5 ± 14.6 years), most common location was back, head and neck, upper and lower extremities, where were frequent occurrence of metastasis (Clark IV). Larger tumors require a wider excision. The greatest incidence was nodular type melanoma and predominant histological were epitheloid type melanoma. Between the size of the tumor masses and the depth of invasion there were no statistically significant positive correlation, which leads to the conclusion that the Clark and Breslow can be used as prognostic factors because they are mutually comparable.

Introduction: Some psychosociodemographic and characteristics of pregnancy and childbirth have been associated with
the onset of postpartum depression in the literature.

Aim: To examine certain psychosociodemographic and characteristics of pregnancy and childbirth as potential risk factors
for the onset of postpartum depression in the early postpartum period. Material and Methods: The study involved 120 subjects, which included the use of the Edinburgh Postpartum Depression Scale and a sociodemographic questionnaire constructed for the purposes of this study, in the early postpartum period.

Results: Of the total 92 (76.7%) subjects were not depressed, while 28 (23.3%) had depression. The high risk of postpartum depression correlates with: postpartum weight gain, subjective experience of lack of freedom, fear that she would be abandoned (p <0.05), as well as having frequent quarrels, mentioning a divorce or divorce, and a temporary separation, poor relationship with the parents on both sides and poor general family atmosphere (p <0.001). A statistically significant risk of depression was also found in the group with complications during childbirth, unplanned pregnancy (p <0.001), as well as alcohol and cigarette consumption during pregnancy (p <0.05).

Conclusion: The risk of postpartum depression can be detected by applying the EPDS scale in the early postpartum period. Early detection of potential risk factors can significantly prevent the onset of postpartum depression and significantly affect the central psychological process in the postpartum period, which is related to the development of an emotional relationship between mother and child.

Introduction:Although placement of the central venous catheter is a routine procedure carried out by anesthesiologists, it
carries a certain risk of complications. One of the complications is malposition, or inadequate catheter position.

Case report: We present a case of the patient who was admitted to an intensive care unit due to head injury and blood
vomiting. The central venous catheter was inserted through the right internal jugular vein. Due to haemodynamic instability and the need for fluid and blood infusion, a chest x-ray examination was not immediately performed to evaluate the position of the catheter. After the patient was stabilized, the test was performed and revealed that the tip of the catheter was not located in the superior vena cava but in the right subclavian vein.

Conclusion: This case has shown that the misplacement of the central venous catheter tip is not unusual. Once in the venous system, even when it is not located in the superior vena cava, it can be used for initial fluid replacement and drug administration, and after the patient is stabilized, the repositioning or placement of a new catheter should be considered. 

Introduction: Stomach cancer is the second in mortality and the fourth most frequent of all cancers in the world. In the recent decades, the number of patients with Signet ring cell carcinoma type has been growing. Unknown etiology with proven risk factors such as smoked and salted foods, smoking, metabolic syndrome, alcohol abuse and Helicobacter pylori infection. Five-year span survival is 20%-40%.

Case outline: Patient, 70 years old, in good health, came to the GP, because of pain she had been feeling in the lower back area for a couple of months. Sometimes she wakes up because of the pain below the chest. Belch, acid, lost three kilograms. Didn't pay any attention to the problem because earlier, due to severe osteoporosis, she had obtained a compression fracture of two vertebrae. Occult bleeding negative. Laboratory normal. Tenderness on palpation of epigastrium, the tumor mass is not palpable. Addressed immediate to esophagogastroduodenoscopy. Diagnosis: Ulcer ventriculi, region antrum. Histopathological findings: Gastric Adenocarcinoma, diffuse type, Signet ring cell. Computed tomography showed locoregional lymphadenopathy so responsible Consilium decided radical surgery and chemotherapy. Despite being treated, the patient pass away two years after the onset of the illness.

Conclusion: Primary health care workers have a big responsibility, because of nonspecific symptoms, in detection of gastric cancer. Good evaluation of patients who should be referred for esophagogastroduodenoscopy is essential. The doctor should keep in mind in the further course of treatment early postoperative complications, Dumping syndrome, appears ventral anastomosis, subocclusive disorders, gallbladders calculus formation, educate patients about nutrition, vitamins, monitor vitamin B12 and iron because patients are prone to vitamin deficiency and pernicious anemia. Psychological support for patients and their families is also very significant, through a concrete doctor-patient relationship. 

Introduction: Glaucoma diagnosis is based on consideration of several factors, such as increased intraocular pressure (IOP), damage to the optical disc, and associated visual field loss. Evaluation of the integrity of the corneal endothelium and monitoring of the corneal thickness is indispensable during the preoperative preparation for phacoemulsification. These data are of great importance for later treatment and monitoring of early and late postoperative complications.

Objective: The aim of this study was to determine the central corneal thickness immediately before and after cataract surgery in patients with primary glaucoma (open and closed angle), comparing them with patients who do not have diagnosed glaucoma. Materials and methods: A prospective study covered a total of 159 subjects who performed cataract surgery by the method of phacoemulsification with the implantation of the intraocular lens in the posterior chamber at the Clinic for Eye Diseases at the Clinical Center of Serbia in Belgrade in 2017 and 2018. Pre-operative patients are classified into two groups. The first group with a primary glaucoma consisted of 71 respondents, with an open angle 41 with glaucoma, and a closed angle glaucoma 30. The second group consisted of people who did not have a diagnosed glaucoma, 88 of them. The central corneal thickness was measured using an ultrasound pachymeter. The measurements were made before the operation, 24 hours, 10 and 30 days after the operation, trying to get all done at the same time of day.

Results: Between patients without glaucoma (BG), primary open-angle glaucoma (POAG) and primary glaucoma of closed angle (PACG), there is a statistically significant difference in median age (χ2 = 10.102; DF = 2; p = 0, 006). Among the observed groups there were statistically significant differences in the values measured preoperatively (χ2 = 10.265; DF = 2; p = 0.006). Among the observed groups, there was no statistically significant difference in the values measured in the first postoperative day (χ2 = 4.364; DF = 2; p = 0.099), nor in the 10th postoperative day (χ2 = 3.250; DF = 2; p = 0.197); 30 days after surgery (χ2 = 1.427; DF = 2; p = 0.490). In each of the groups individually, the appearance of oedema or a very statistically significant difference in the first and tenth postoperative day. Statistically significant difference was present 30 days after surgery, but far less compared to early postoperative period.

Conclusion: Based on the values obtained in this prospective study, we estimate that monitoring of corneal thickness has a mandatory place in the observation of patients after cataract surgery. We found that there is no difference in preoperative measurement only between groups without glaucoma and open angle glaucoma. Measurements performed in the first, tenth, thirtieth day do not differ in groups, but edema restitutin in the 30-th day was observed in all observed groups. 

The most significant prostate diseases (PD) are benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia
(PIN) and prostate cancer (PC). Generally, all PD are rare before the age of 50 with growing number of patients, primarily
with BHP, with each next decade, but about decade later the highest number of PIN and PC began to report. The aim of this
paper is to examine some of clinical, biochemical and histopathological characteristics of BPH, PIN and PC. Our sample
consisted of 169 men. Statisticaly the most common PD was BPH-77.5%, and the rarest PIN-8.3% (p<0.001). The average age of patients was 70.6±7.5 years (51-89) with no significant differences between diagnosis (p=0.415). PIN and PC are more often found in people from urban areas (p=0.004). In the central prostate area BPH is significantly higher in 88.5% (p<0.001). Peripheral parts are significantly more common places of PIN and PC (p<0.001). Median serum PSA values is statistically highest in PC-87.2 ng/ml (12.7-372.5), (p<0,001), especially those with predominantly peripheral parts localization. Gleason score is an important prognostic factor, with average value at PC is 7.32±1.4 (5-10), with a significantly higher values for diffuse PC. BPH is the most common, and PIN rarest PD. All diseases have occurred in people older than 50 years. Usually, BPH is in central and PIN and PC in peripheral prostate parts. PSA values were highest at PC, which is a prove of its importance in malignancy early detection.

Introduction: Asphyxiation by aspiration- inhalation of foreign bodies is a form of violent mechanical asphyxia and can occur at any age, most commonly in children and the elderly. In children up to third age choking is a significant cause of morbidity and mortality. Mortality due to aspiration of foreign bodies is higher in children because of the relatively narrow airways and less developed protective mechanisms. The size, type, shape and place of obstruction with foreign body leads to the diversity of clinical picture.

Case report. We present the case of a 15 month-old girl, who was found by her mother in her house in a village, lying down, cyanotic, collapsed, without breathing. Autopsy showed that the cause of death was acute respiratory obstruction with impacted grains of corn in two places, on the larynx entrance and in the right bronchus.

Conclusion. The diagnosis of death by asphyxiation due to aspiration of foreign bodies is set at autopsy, when the place of airway occlusion is found. If a foreign body was removed during providing assistance, the diagnosis would be made based on medical records or history data of persons who were provided assistance. In cases of sudden deaths of young children, in order to clarify pathophysiological mechanism and mode of death in each case, a pathologist should always keep in mind the possibility of aspiration of foreign bodies, and in accordance with this, carefully apply appropriate autopsy techniques to locate the place of obstruction, with special regard to local finding in airways.

Introduction: Primary mediastinal large B cell lymphoma is a rare highly aggressive form of non-Hodgkin lymphoma and occurs in 5-7% of all diffuse large B lymphoma and 2% of all non-Hodgkin lymphomas. Originates from thymic medullary cells and has its own histogenesis. Typically affects young women in the third and fourth decade of life. Superior vena cava syndrome is present in more than 50% of cases, with swelling of face, hands, deep venous thrombosis, dyspnea, dysphagia, chest pain, headache and cough. Diagnosis is made by histopathological analysis and immunohistochemical surgical biopsy specimens obtained mediastinoscopy. Timely treatment with cycles of monoclonal antibody and chemotherapy is requirement to relapse and stable state.

Case outline: Patient, 37 years old, came for the first time for review at General practice because she has been repeatedly visited emergency service due to coughing, feeling that something is strangling, the lack of air pressure and pain in the head and swelling of face and neck. Started detailed diagnostics. Radiologically determined mediastinal tumor, computed tomography confirmed it and sent to the referral Institute where video-assisted thoracic surgery and patho histology diagnosed PMBCL CSII AM +. Administered six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone therapy protocols submitted by the expected side effects. Control positron emission tomography found that the tumor mass completely withdrawn. In remission for two years, have a good feeling and occurs at regular checkups.

Conclusion: General practice has a big responsibility in recognizing early symptoms of malignant disease that accelerates
the diagnosis and timely start of treatment.