Gastrointestinal stromal tumors (GIST omi) are a heterogeneous group of mesenchymal tumors. Etiological factors that cause GIST ome are not clearly distinguished, characterized by remarkable diversity of the clinical, histopathological and genetic features. Mitotic activity, nuclear pleomorphism, degree of cellularity, nuclear-cytoplasmic ratio, tumor size, mucosal invasion, tumor ulceration and necrosis, are factors that determine the malignancy of these tumors. The most common location of these tumors of the stomach and small intestine, while very rare localization of the colon, esophagus and rectum. Despite the progress that has been made in the diagnosis and further diagnosis of intra - or postoperative. The aim of this report is to contribute to easier recognizing the symptoms, diagnosis and treatment of these tumors. It was a mixed tumor, epitheloid-spindle type cells, immunohistochemical analysis, we have a positive expression of CD 117 and CD 34.
Pappo A, Katherine, Janeway K. Pediatric Gastrointestinal Stromal Tumors Clinical Update on Adult and Pediatric Gastrointestinal Stromal Tumor Volume. (1):15–34.
2.
De Silva C, Reid R. Gastrointestinal stromal tumors (GIST):C-kit mutations, CD117 expression, differential diagnosis andtargeted cancer therapy with Imatinib. Pathol Oncol Res. 2003;(1):13–9.
3.
Fletcher C, Berman J, Corless C, Gorstein F, Lasota J, Longley B. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002;(5):459–65.
4.
Steigen S, Eide T. Gastrointestinal stromal tumors (GISTs): a review. APMIS. 2009;(2):73–86.
5.
Boni L, Benevento A, Dionigi G, Rovera F, Dionigi R. Surgical resection for gastrointestinal stromal tumors (GIST): experience on 25 patients. World J Surg Oncol. 2005;78.
6.
Otani Y, Furukawa T, Yoshida M, Saikawa Y, Wada N, Ueda M, et al. Operative indications for relatively small (2-5 cm) gastrointestinal stromal tumor of the stomach based on analysis of 60 operated cases. Surgery. 2006;(4):484–92.
7.
Rubin B, Heinrich M. Corless CL Gastrointestinal stromal tumour. Lancet. 2007;(9574):1731–41.
8.
Cao H, Zhang Y, Wang M, Shen D, Sheng Z, Ni X, et al. Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease. Chin Med J (Engl). 2010;(2):131–6.
9.
Akahoshi K, Sumida Y, Matsui N, Oya M, Akinaga R, Kubokawa M, et al. Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspirationWorld J Gastroenterol. 2007;(14):2077–82.
10.
Blay J, Bonvalot S, Casali P, Choi H, Debiec-Richter M, Tos D, et al. Ann Oncol. (4):566–78.
11.
Mahzouni P, Jafari M. The study of CD117 expression in glial tumors and its relationship with the tumor-type and grade. J Res Med Sci. 2012;(2):159–63.
12.
Fletcher C, Berman J, Corless C, Gorstein F, Lasota J, Longley B. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002;(5):459–65.
13.
Rodriguez S, Faigel D. Endoscopic diagnosis of gastrointestinal stromal cell tumors. Curr Opin Gastroenterol. 2007;539–54.
14.
Parfitt J, Streutker C, Riddell R, Driman D. Gastrointestinalstromal tumors: a contemporary review. Pathol Res Pract. 2006;(12):837–47.
15.
Amato D, Steinert G, Mcauliffe D, Trent J, J. Update on the biology and therapy of gastrointestinal stromal tumors, Department of Sarcoma Medical Oncology. Cancer Control. 2005;(1):44–56.
16.
Samelis G, Ekmektzoglou K, Zografos G. Gastrointestinal stromal tumours: clinical overview, surgery and recent advances in imatinib mesylate therapy. Eur J Surg Oncol. 2007;(8):942–50.
17.
Sjolund K, Kindblom L, Meis-Kindblom J, Bumming P, Nilsson O, Andersson J, et al. Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumours (GIST). Br J Cancer. 2007;(11):1656–8.
18.
Andtbacka R, Ng C, Scaife C, Cormier J, Hunt K, Pisters P, et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib. Ann Surg Oncol. 2007;(1):14–24.
Lin S, Huang M, Zeng C. Wang 1’1, Liu ZL, Shiay RK. Clinicalmanifestationsand prognosticfactors in patients with gastrointestinalstromal tumors. World JGastrocnterol. 2003;(12):2809–12.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
