Danas gojaznost predstavlja globalni epidemiološki problem koji tokom vremena postoji sve veći. Međutim, efekti gojaznosti na respiratorni sistem često su neuvaženi. U ovom članku biće sagledani mehanički efekti gojaznosti na fiziologiju pluća kao i funkcija masnog tkiva kao endokrinog organa na produkciju sistemske inflamacije i uloge na centralnu kontrolu disanja. Gojaznost igra ključnu ulogu u razvoju opstruktivne apnee u spavanju i opstruktivnog hipoventilacionog sindroma. Bolje razumevanje efekata gojaznosti na respiratorne bolesti i pružanje adekvatnih mera zdravstvene zaštite je od vitalnog značaja u sprečavanju ovog sve značajnijeg problema.
World Health Organization Obesity and overweight. Fact Sheet N. 2010;311.
2.
Lena M, Lara J, Hill J. ABC of obesity. Strategies for preventing obesity. BMJ. 2006;959–62.
3.
Halsam D, Sattar N, Lean. ABC of obesity. Obesity-time to wake up. BMJ. 2006;642.
4.
Mcclean K, Keef, Zoung I, Elborn J. Obesity and the lung: 1 Epidemiology Thorax. 2008;649–54.
5.
Koenig S. Pulmonary Complications of obesity. Am J Med Sci. 2001;249–79.
6.
Murugan A, Sherma G. Obesity and respiratory disease. Chron Respir Dis. 2008;233–42.
7.
Stunkard A. Current views on obesity. Am J Med. 1996;230–6.
8.
Mcclean K, Cardwell C, Kee F. Longitudinal change in BMI and lung function in midle-aged men in Northern Ireland. Ir J Med Sci. 2007;(Suppl10).
9.
Nakajima K, Kubouchi Y, Muneyuki T, Ebata M, Eguchi S, Munakata H. A possible association between suspected restrictive pattern as assessedby ordinary pulmonary function test and the metabolic syndrome. Chest. 2008;712–8.
10.
Jones R, Nzekwu M. The effects of body mass index on lung volumes. Chest. 2006;827–33.
11.
Ochs-Balcom H, Grant B, Muti P. Pulmonary function and abdominal adiposity in the general population. Chest. 2006;853–852.
12.
Waannamethee S, Shaper A, Whincup P. Body fat distribution, body composition, and respiratory function in elderly men. Am J Clin Nutr. 2005;966–100.
13.
Babb T, Ranasinghe K, Comeau L, Semon T, Schwartz B. Dyspnoea on exertion in obese women. Am J Resp Crit Care Med. 2008;116–23.
14.
Malhotra A, Hilman D. Obesity and the lung:3. Obesity, respiration and intensive care. Thorax. 2008;925–31.
15.
Courbon N, Thomas D, F. Lung function impairment and metabolic syndome. The ceitical role of abdominal obesity. Am J Respir Crit Care Med. 2009;509–15.
16.
Hacken Nick HT. Physical inactivity and obesity. Proc Am Thorac Soc. 2008;663–7.
17.
Patil S, Schneider H, Marx J, Gladmon E, Schwartz A, Smith P. Neuromechanical control of upper airway patency during sleep. J Appl Physiol. 2007;
18.
Gozal M. Update on sleep medicine. Am J Respir Crit Care Med. 2009;545–9.
19.
Crummy F, Piper A, Noughton M. Obesity and the lung:2. Obesity and sleep-disordered breathing. Thorax. 2008;738–46.
20.
Lettieri C, Eliasson A, Greenburg D. Persistence of obstructive sleep apnea after surgical weight loss. J Clin Sleep Med. 2008;(4):333.
21.
Isono S. Obstructive sleep apnea of obese adults. Anesthesiology. 2009;908–21.
22.
Scafer H, Pauleit D, Sudhop T, Gouni-Berthold I, Ewig S, Berthold H. Body fat distribution, serum leptin and cardiovascular risk factors in men with obstructive sleep apnea. Chest. 2002;829–39.
23.
Candiotti K, Sharma S, Shankar R. Obesity obstructive sleep apnea, and diabetes mellitus: anaeathetic implications. Br J Anesth. 2009;(Suppl1):23–30.
24.
Horner R. Contributions of passive mechanical loads and active neuromuscular compensation to uperr airway collapsibility during sleep. J Appl Phisiol. 2007;510–2.
25.
Sato M, Suzuki M, Suzuki J. Overweight patients with severe sleep apnea experience deeper oxygen desaturation at apnoeic events. J Med Dent Sci. 2008;43–7.
26.
Tagaito Y, Isono S, Remmers J, Tanaka A, Nishino T. Lung volume and collapsibility of the passive pharynx in patients with sleep-disordered brething. J Appl Phisiol. 2007;1379–85.
27.
Heinzer R, White D, Malhotra A. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnea. Am J Resp Crit Care Med. 2005;114–7.
28.
Heinzer R, Stanchina M, Malhotra A. Lung volume and continuous airway pressure requirements in obstructive sleep apnea. Am J Resp Crit Care Med. 2005;114–7.
29.
Newman A, Foster G, Givelber R, Nieto F, Redline S, Young T. Progression and regression of sleep-disordered breathing weith changes in weight. Arch Intern Med. 2005;2408–13.
30.
Young T, Peppard P, Taheri S. Excess wight and sleep-disordered breathing. J Appl Physiol. 2005;1592–9.
31.
Toumilehto H, Seppa J, Markku M. Lifestyyle intervention with weight reduction:first-line treatment in mild obstructive sleep apnea. Am J Respir Crit Care Med. 2009;320–7.
32.
Greenburg D, Lettieri C, Eliasson A. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med. 2009;535–42.
33.
Marshall N, Grunstein R. Losing wight in moderate to severe obstructive sleep apnea. BMJ. 2009;(4363).
34.
Teichathl H. The obesity-hipoventilation syndrome revisited. Chest. 2001;336–9.
35.
Donnel O, Schaub C, Haines C, A. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med. 2000;1477–84.
36.
Makinodan K, Yoshikawa M, Fukuoka A. Effect of serum leptin levels on hypercapnoeic ventilatory response in obstructive sleep apnea. Respiration. 2008;257–64.
37.
Chin K, Shimizu K, Nakamura T. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continous positive airway pressure therapy. Circulation. 1999;706–12.
38.
Chiner E, Liompart M, Martinez-Garcia M, Fernandez-Fabrellas E, Navarro R, Cervera A. Noninvasive mechanical ventilation in Valencia, Spain: from theory to practise. Arch Bronconeumol. 2009;(3):118–30.
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