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CONNECTION OF TUMOR BUDDING, LYMPHATIC VESSEL INVASION AND LYMPH NODE METASTASIS IN COLORECTAL CARCINOMAS
Institute of Pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Published: 01.01.2010.
Volume 38, Issue 1 (2010)
pp. 77-81;
Abstract
Tumor budding refers to an isolated cell or a cluster of up to five undifferentiated tumor cells, located in the stroma close to the invasion frontline of a carcinoma. It has been observed that tumor budding invariably precedes both an invasion into the lymphatic vessels surrounding a tumor and the development of metastases in lymphatic nodes. The aim of this paper is to determine the link between tumour budding, lymphatic vessel invasion and presence o lymph node metastasis in colorectal carcinomas. The study involved 92 cases of colon and upper rectum cancers removed at the Trebinje General Hospital and the Medical Centre in Kosovska Mitrovica. High-grade tumour budding was diagnosed in 66 (71.7%) cases, and lowgrade tumour budding in 26 (20.3%) cases. Lymphatic invasion was detected in 63 (68.5%) cases (55 (87.3%) of these cancers showed high-grade tumour budding, while on the other hand 8 (12.7%) had low-grade tumour budding). Lymphonodal metastases were found in 45 (48.9%) cases (of which 36 (80.0%) were high-grade and 9 (20.0%) low-grade incidents). Based on the ÷2-test, it may be concluded that the distribution of tumour budding in relation to lymphatic invasion (p<0.001) is statistically very significant, which was not confirmed in the case of metastases developing in lymphatic nodes (p>0.05). In conclusion, tumour budding is highly linked to lymphatic invasion, which it most probably precedes.
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