It is well known that intensive physical activity increase the production of reactive species of O and N (RONS), but 2 it is also known that moderate and regular physical activity has influence on antioxidative system adaptation and help in repairing process of oxidative damage. In this paper we estimated markers of lipid peroxidation (MDA, % ind MDA), and antioxidant status (Asc, DHA/A, GSH, CAT, Pex) for 30 students (control group), and 30 professional football players (regular intensive physical activity). In the group of professional sportsman there were significant increase of lipid peroxidation markers (MDA ↑, % ind MDA ↑), which was also followed by an increased antioxidant activity (Asc ↑, DHA/A ↑, GSH ↑, Pex ↑, CAT ≈). We can conclude that chronic physical activity significantly improves antioxidant status using the adaptation process.
Aslan R, Sekeroglu MR, Tarakcioglu M, Bayiroglu F, Meral I. Effect of acute and regular exercise on antioxidative enzymes, tissue damage markers, and membrane lipid peroxidation of erythrocytes in sedentary students. Tr J Med Sci. 28:411–4.
2.
Svensson MB, Ekblom B, Cotgreave IA, Norman B, Sjöberg B, Ekblom Ö, et al. Adaptive stress response of glutathione and uric acid metabolism in man following controlled exercise and diet. Acta Physiol Scand. 176(1):43–51.
3.
Dalton TP, Li Q, Bittel D, Liang L, Andrews GK. Oxidative stress activates metal-responsive transcription factor-1 binding activity: Occupancy in vivo of metal response elements in the metallothionein-I gene promoter. J Biol Chem. 271(42):26233–41.
4.
Janssen YM, Sen CK. Nuclear factor kappa B activity in response to oxidants and antioxidants. Methods Enzymol. 300:363–74.
5.
Davies KJA. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life. 50(4–5):279–89.
6.
7.
McArdle A, Pattwell D, Vasilaki A, Griffiths RD, Jackson MJ. Contractile activity-induced oxidative stress: Cellular origin and adaptive responses. Am J Physiol Cell Physiol. 280(3).
8.
Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Ha S, et al. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol. 84(1–2):1–6.
9.
Evelo CTA, Palmen NGM, Artur Y, Janssen GME. Changes in blood glutathione concentrations and in erythrocyte glutathione reductase and glutathione S-transferase activity after running training and after participation in contests. Eur J Appl Physiol. 64(4):354–8.
10.
Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr. 72(2).
11.
Subudhi AW, Fu MX, Strothkamp KG, Murray DM. Effect of graded exercise on blood glutathione status in trained and untrained humans. Int Sports J. 7:82–90.
12.
Brites FD, Evelson PA, Christiansen MG, Nicol MF, Basilico MJ, Wikinski RW, et al. Soccer players under regular training show oxidative stress but an improved plasma antioxidant status. Clin Sci. 96:381–5.
13.
Robertson JD, Maughan RJ, Duthie GG, Morrice PC. Increased blood antioxidant systems of runners in response to training load. Clin Sci (Lond. 80(6):611–8.
14.
Khassaf M, Child RB, McArdle A, Brodie DA, Esanu C, Jackson MJ. Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise. J Appl Physiol. 90(3):1031–5.
15.
Radák Z, Naito H, Kaneko T, Tahara S, Nakamoto H, Takahashi R, et al. Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflügers Arch Eur J Physiol. 445(2):273–8.
16.
Yagi K. Lipid peroxides and exercise. Med Sci Sports Exerc. 21:37–40.
17.
Somani SM. Influence of exercise-induced oxidative stress on the central nervous system. In: Exercise and Oxygen Toxicity. p. 463–79.
18.
Lew H, Quintanilha A. Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification. Eur J Drug Metab Pharmacokinet. 16(1):59–68.
19.
Gül M, Atalay M, Hänninen O. Endurance training and glutathione-dependent antioxidant defense mechanism in heart of diabetic rats. J Sports Sci Med. 2:52–61.
20.
Tiidus PM, Houston ME. Antioxidant and oxidative enzyme adaptations to vitamin E deprivation and training. Med Sci Sports Exerc. 26(3):354–9.
21.
22.
Leeuwenburgh C, Fiebig R, Chandwaney R, Ji LL. Aging and exercise training in skeletal muscle: Responses of glutathione and antioxidant enzyme systems. Am J Physiol Regul Integr Comp Physiol. 267(2).
23.
Gul M, Laaksonen DE, Atalay M, Vider L, Hänninen O. Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats. Scand J Med Sci Sports. 12(3):163–70.
24.
Sen CK, Marin E, Kretzschmar M, Hanninen O. Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization. J Appl Physiol. 73(4):1265–72.
25.
Venditti P, Meo S. Antioxidants, tissue damage, and endurance in trained and untrained young male rats. Arch Biochem Biophys. 331(1):63–8.
26.
Kanter MM, Hamlin RL, Unverferth DV, Davis HW, Merola AJ. Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubicin. J Appl Physiol. 59(4):1298–303.
27.
Moller P, Wallin H, Knudsen LE. Oxidative stress associated with exercise, psychological stress, and lifestyle factors. Chem-Biol Interact. 102(1):17–36.
28.
Mastaloudis A, Yu TW, O’Donnell RP, Frei B, Dashwood RH, Traber MG. Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med. 36(8):966–75.
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