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ACTIVITY XANTHINE OXIDOREDUCTASE AND OXIDATIVE STRESS IN PLASMA HYPERTENSIVE AND HEART FAILURE PATIENTS ASSOCIATED WITH AGE-RELATED CATARACT
Institute of Biochemistry, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Biochemistry, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Institute for Preventive Medicine, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of Biochemistry, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Clinic for Eye Diseases, Medical Faculty Priština , Kosovska Mitrovica , Kosovo*
Centre of Medical Biochemistry, Health Centre Kosovska Mitrovica , Kosovska Mitrovica , Kosovo*
Published: 01.01.2010.
Volume 38, Issue 1 (2010)
pp. 7-11;
Abstract
Oxidative stress and associated oxidative damage are mediators of vascular injury and inflammation in many cardiovascular diseases, including hypertension, atherosclerosis, ischemic heart disease, diabetes. Xanthine oxidoreductase is one of the enzymes producing free radicals in the cardiovascular system, and it can contribute to the increment of the oxidative stress and, consequently, blood pressure. The xanthine oxidase is a molybdoenzyme capable of catalyzing the oxidation of hypoxanthine and xanthine in the process of purine metabolism. Xanthine oxidase can exist in two interconvertible forms, either as xanthine dehydrogenase or xanthine oxidase. The aim of the paper was investigate the activity xanthine oxidoreductase in the plasma patients with age related cataract, with hypertensive, and with heart failure. Clinical and biochemical researches were carried out in 73 patients with age related cataract, mean age 72±7 years, divided into group with hypertensive (N=35), with heart failure (N=22) and group normotensive and without heart failure (N=16). Plasma xanthine oxidoreductase activity was determined spectrophotometrically by measuring the formation of uric acid from hypoxanthine at 293 nm. The concentration of triglycerides (TG), total cholesterol (TC), LDL-C, HDL-C in plasma were determined. Our findings show a significantly increased activity xanthine oxidoreductase in plasma hypertensive patients (XO 9.18±1.5 U/L) (p< 0.001) and patients with heart failure (XO 10.44±1.53U/L) (p< 0.001), compared with values plasma xanthine oxidoreductase activity in normotensive and patients without heart failure (XOD 6.02±1.4 U/L). Concentrations of plasma TG, TC and LDL-C were elevated in groups with hypertensive and with heart failure, and we to find significant differences with group normotensive and without heart failure values. Elevated activity of plasma xanthine oxidoreductase contribute to the increasåd oxidative stress and may play a role in accelerated atherosclerosis.
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