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PARAMETERS OF OXIDATIVE STRESS AND ANTIOXIDATIVE POWER IN THE AQUEOUS IN PATIENTS WITH DIABETES AND AGE- RELATED CATARACT
Clinic of Eye Disease, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Institute of biochemistry, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Clinic of Eye Disease, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Clinic of Eye Disease, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Clinic of Eye Disease, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Clinic of Eye Disease, Medical faculty Priština , Kosovska Mitrovica , Kosovo*
Published: 01.01.2010.
Volume 38, Issue 1 (2010)
pp. 54-56;
Abstract
Any kind of ocular lens opacification is well known as cataract. Most cataracts are age-related, so called senile cataract. Cataractogenesis as process involves either pathological and natural aging processes. Chronical oxidative stress is considered as primary factor in age-related cataractogenesis. In this study we measured concentration of lipid hydroperoxides, sulfhydril groups (SH) and entire antioxidative capacity,as well as ocular superoxide dismutase and catalase activity in 11 subjects with diabetes mellitus (DM) type 2 and cataract and in 39 nondiabetic subjects with senile cataract. All patients underwent complete ophthalmological examination before they were surgically treated by phacoemulsifications. 0 During the intervention, aqueous sample in volume 0,2 was aspirated and refrigerated in -20 C and preparated for further biochemical analysis. Parameters of antioxidative power in diabetic subjects with cataract have decreased values (sulfhydril groups and antioxidative potential - FRAP test) in aqueous while one of lipid peroxidation product has increased value (lipid hyperoxide). Aqueous catalase activity in subjects with diabetes and senile cataract is remarkably higher compared with nondiabetic subjects (p<0.0.5). Oxydative stress and antioxidative capacity are well known risk factor in cataractogenesis but in DM 2 patients, oxydative stress is more intensive than in control group.
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