HISTOPATOLOGICALAND CLINICOMORPHOLOGICAL CHARACTERISTICS OF MALIGNANT TUMORS OF THE SKIN

M. Vančentović-Mijović ,
M. Vančentović-Mijović

Institute of pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

N. Mitić ,
N. Mitić

Institute of pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

D. Vukićević ,
D. Vukićević

Institute of pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

Z. Dolićanin ,
Z. Dolićanin

Institute of pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

B. Đerković
B. Đerković

Institute of pathology, Medical faculty Priština , Kosovska Mitrovica , Kosovo*

Published: 01.01.2009.

Volume 37, Issue 1 (2009)

pp. 85-92;

https://doi.org/10.70949/pramed200901279V

Abstract

Malignant tumors of the skin (MTS) are between the most common malignant tumors at human population. Because of their similarities, and more important, their dissimilarities, it is very important to determinate histophologycal type, grading and staging, because they are the most important factors of therapy choise and prognosis. The aim of our work was to examine those parameters, and also to define sex, age and locations distribution, as well as the value of surgical treatment. We analysed biopsy material of Institute of pathology, Medical faculty Priština from 2004-2007. year. We found that squamocellular carcinoma (SCC) and basal cell carcinoma (BCC), and malignant melanoma (MM) were more common at older persons, about 2x more common at male, little bit younger at persons with BCC and MM than SCC. The most common location was skin face; at persons with SCC and BCC significant more common than on all other skin locations. SCC was more common below, and BCC was more common on skin face above imagine line from tragus to the same side lips corner. Average size was about 1,5 cm, and macroscopic they were ulcerous, verrucous and infitrative. Invasive SCC was diagnosed in 2/3 cases in the most early stadium. In opposite MM was diagnosed in late stadium in majority cases. Moderate inflammatory infiltrate was found in most cases of all MTS. MTS was adequate removed in the most part cases.

Keywords

References

1.
D. R, M. P, H. Z. UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin. J Am Acad Dermatol. 44:293–7.
2.
Lever W. Histopathology of Skin. Lippincott Company. 1975:398–441.
3.
H.W. L, K C. The health impact of solar radiation and prevention strategies. J Am Acad Dermatol. 41:81–9.
4.
Marks R. An overview of skin cancers: Incidence and causation. Cancer. 75:607–12.
5.
A.H M. Aggressive basal cell epithelioma on sunlight-protected skin: Report of eight cases, one with pulmonary and bone metastases. Am J Dermatopathol. 5:221–9.
6.
R.L M. Clinical presentation of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol. 42:8–10.
7.
Oprić M. Marković Lj.: Pigmentni tumori kože, Naučna knjiga.
8.
Piepcorn M. Melanoma genetics: An update with focus on the CDKN2A (p16)/ARF tumor suppressors. J Am Acad Dermatol. 42:705–22.
9.
D. P, R S. Nonmelanoma cancers of the skin. N Engl J Med. 327:1649–62.
10.
N. PI, R V. Histopathologic variants of basal cell carcinoma: Correlation with sex, age, and localization. Acta Derm Croat. 3:3–9.
11.
I.R.H. K, R.B. K, J.J P. Sobin L.H.: Definition of leukoplakia and related lesions: An aid to studies on oral precancer. Oral Surg. 46:518.
12.
S. R, R. C, V K. Pathologic Basis of Disease.
13.
K. R, V. A, M. S, M J. Rončević D.: Invasive, aggressive basal cell carcinoma. European Journal of Plastic Surgery. 6:379–84.
14.
Salache S. Epidemiology of actinic keratosis and squamous cell carcinoma. J Am Acad Dermatol. 42:4–7.
15.
L.M S. Review of the 2001 AJCC staging system for cutaneous malignant melanoma. Curr Oncol Rep. 3:332–7.
16.
S. S, M. P, V. S, V. D. Epidemiological characteristics of basal cell skin epithelioma treated at the Department of Dermatovenereal Diseases in Novi Sad. Med Pregled. 46(11–12):413–6.
17.
Šitum M. Malignant Tumours of Skin and Soft Tissue. Medicus. 10(2):237–45.
18.
Urbach F. Geographic pathology of skin cancer. In: International Conference on the Biologic Effects of Ultraviolet Radiation (with Emphasis on the Skin. p. 635–50.
19.
Urbach F. Incidence of nonmelanoma skin cancer. Dermatologic Clinics. 9:751–5.
20.
M. C, P. B, J. A, M. S, G.R M. Ring I.: Trends for in situ and invasive melanoma in Queensland, Australia 1982-2002. Cancer Causes Control. 17(1):21–7.
21.
A.E. B, K Y. The hedgehog pathway and basal cell carcinomas. Hum Mol Genet. 10:757–62.
22.
Barnhill R. Malignant melanoma, dysplastic melanocytic nevi, and Spitz tumors. Clin Plast Surg. 27:331–60.
23.
Здесь следует добавить информацию о статье, так как сейчас она отсутствует.
24.
V. B, S. E, H. S, G M. Cutaneous factors related to the risk of malignant melanoma. Br J Dermatol. 109:165–72.
25.
Berking C. The role of UV irradiation in malignant melanoma. Hautarzt. 56(7):687–96.
26.
M. B, I. K, B K. Lichen planus: A clinical and epidemiological study. J Dermatol. 27:576–82.
27.
DE. B, JA. R, JA. S, A. L, GJ. M, HP. B, et al. Ponten J.: A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA. 88:10124–8.
28.
O. BF, G. P, H.H W. Burgdorf W.H.C.: Malignant Epithelial Tumors.
29.
Chin L. The genetics of malignant melanoma. Nat Rev Cancer. 3:559–70.
30.
C.M. B, S.J. S, J.E. G. Prognostic factors analysis of 17,600 melanoma patients. J Clin Oncol. 19:3622–34.
31.
Vries E., F.I. B, J.W C. Park D.M.: Changing epidemiology of malignant cutaneous melanoma in Europe 1953-1997: rising trends in incidence and mortality but recent stabilization in Western Europe and decreases in Scandinavia. Int J Cancer. 107(1):119–26.
32.
V. E, V. M, V. T, R D. Betts C.M.: Endocrine differentiation in basal cell carcinoma. Tumori. 65:123–6.
33.
E. G, P.E S. Wick M.R.: Neuroendocrine differentiation in basal cell carcinoma: An immunohistochemical study. Am J Dermatopathol. 11:131–5.
34.
M.L. G, W.M. K, R.B. C. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 92:709–20.
35.
K. G, L. C, V. S, R S. Muneoka L.: Skin cancer prevention for children, parents and caregivers: A field test of Hawaii’s Sun Smart program. J Am Acad Dermatol. 38:413–7.
36.
B.G G. Goldstein A.O.: Diagnosis and management of malignant melanoma. Am Fam Physician. 63:1359–68.
37.
M.D JR. Ackerman’s Surgical Pathology.
38.
K.H. K, M.M. L, A.D A. Lambert W.C.: The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. Arch Dermatol. 130:1018–21.

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