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ENTS WITH PURULENTMENINGITIS MYELOPEROXIDASE ACTIVITY IN SERUM AND CEREBROSPINAL FLUID OF PATIENTS WITH PURULENT MENINGITIS
Institute of Biochemistry, Medical faculty, Pristina , Kosovska Mitrovica , Kosovo*
Clinic for Infective Diseases, Clinical Center Pristina , Gracanica , Bosnia and Herzegovina
Institute of Biochemistry, Medical faculty, Pristina , Kosovska Mitrovica , Kosovo*
Institute of Biochemistry, Medical faculty, Pristina , Kosovska Mitrovica , Kosovo*
Published: 01.01.2008.
Volume 36, Issue 1 (2008)
pp. 7-10;
Abstract
Myeloperoxidase (MPO), a heme enzyme present in the primary granules of polymorphonuclear leukocytes (PMNs) participate in oxygen-dependent microbicidal activity of these cells. During the course of bacterial meningitis plenty of PMNs leave blood vessels and migrate to cerebrospinal fluid (CSF) space, and some of their MPO may become, extracellular. MPO activity in control CSF is low (Me = 0.5 U/L), comparing with patients CSF samples of all three groups of proteinorrachia where elevated values were found already on admission (3.5 U/L, 5.0 U/L and 12.0 U/L, respectively), with highest values found during second lumbal punction (5.5 U/L, 7.5 U/L and 14.0 U/L, respectively). Poor correlation was found between albumin quotient and MPO activity CSF/serum, but significant correlation between MPO in CSF and CSF PMNs count.
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