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DOXYCYCLIN IN INHIBITION OF METALLOPROTHEASIS IN GONARTHROSIS
Internal clinic, reumatology, Medical faculty Pristina , Коsоvsка Мitrovica , Kosovo*
Published: 01.12.2006.
Volume 34, Issue 2 (2006)
pp. 31-32;
Abstract
Gonarthrosis is degenarative knee disease as well as the commonest chronic knee arthropaty. Nowadays more attention is given to modern pathogenesis of arthrosis in two levels: 1. immunological; 2. some ferments disbalance phenomenon. In the second level of pathogenesis, a special atention is given to metalloprotheasis. The importance of doxycyclin on the reduction of metalloprotheasis in synovia has a great therapy importance not only theoretically but pratically as well 78 patients with primary and secundary gonarthrosis has been examined (19 men and 59 women) the appliance of doxycyclin in clinic elements common for gonarthrosis caused the improvemnt of all clinic parameters especially muscular strenght and pain, but the largest improvement was noticed in knee - joint circumference
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