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EHOCARDIOGRAPHIC CHARACTERISTICS OF LEFT VENTRICLE IN NON-Q ACUTE MYOCARDIAL INFARCTION

VITAMIN C CONCENTRATIONS IN SERUM BEETWEN PATIENTS SUFFERING FROM DIFFERENT FORMS OF NON-SPECIFIC OSTEOMYELITIS

QUALITY QUALITY AND EFFICACY AND EFFICACY OF A TELECOLPOSCOPY TELECOLPOSCOPY PROGRAMME PROGRAMME

RECURENT ECURENT CHILDREN HEADACHES IN CHILDREN HEADACHES IN VOJVODINA

PREGNANCY TERMINATION AT PRENATALLY DIAGNOSTIFIED FETAL ANOMALY: TWO PROTOCOL COMPARATION

VITAMIN C CONCENTRATIONS IN SERUM BEETWEN PATIENTS SUFFERING FROM DIFFERENT FORMS OF NON-SPECIFIC OSTEOMYELITIS

D. Mirić ,
D. Mirić

.Institute for Biochemistry, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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R. Grbić ,
R. Grbić

.CHC Pristina, Clinic for Orthopaedic surgery, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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A. Vasić ,
A. Vasić

CHC Pristina, Clinic for Orthopaedic surgery, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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B. Božović ,
B. Božović

Institute for Biochemistry, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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I. Dragojević ,
I. Dragojević

Institute for Biochemistry, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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M. Marković ,
M. Marković

CHC Pristina, Clinic for Orthopaedic surgery, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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V. Nestorović
V. Nestorović

Institute for Physiology, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*

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Published: 01.12.2006.

Volume 34, Issue 2 (2006)

pp. 7-11;

https://doi.org/10.70949/pramed200602146M

Abstract

Bone tissue infections caused by non-specific agents (non-specific osteomyelitis) occur most frequently among children and young individuals demanding surgical and antibiotic therapy, although with unpredictable clinical outcome. While mobilization of cellular response to infectious agents takes place, a bulk of oxygen-derived free radicals emerge with concomitant participation of various elements of endogenous antioxidative defense. Vitamin C is an endogenous antioxidant active in the aqueous phase. It is very likely that ostoemyelitic patients already have some kind of disorder in specific antioxidant system due to hematogenic origin of non-specific osteomyelitis. Our results show that serum total vitamin C concentrations among patients with non specific osteomyelitis are not significantly different from those obtained among control subjects. However, we found significantly different concentrations of ascorbate, dehyroascorbate and their concentration ratio in serum within osteomyelitic patients that points to enlarged consumption of ascorbate even before the bone localization of infection took place

Keywords

Osteomyelitis,

Vitamin C,

Oxygen-derived free radicals,

Antioxidative defense

References

1.
G.A.C. M, M.J.O. F, L B. Oxygen free radicals stimulate fibroblast proliferation. Biochem Soc Trans. 17:484–5.
2.
J.M. B, C. H, A.D. F, I.R. S, W.J S. Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus. Proc Natl Acad Sci USA. 77(5):2711–5.
3.
H. T, T. M, Y. M, T. Y, H. M, S S. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration. Arch Surg. 135:326–31.
4.
T. M, C.A. E, I. R, I.S. R, L.W J. Antioxidants attenuate endotoxin-induced microvascular leakage of macromolecules in vivo. J Appl Physiol. 70(4):1483–9.
5.
S.F. W, B. H, R. R, W.R S. Role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and ascorbic acid. J Inorg Biochem. 15:127–34.
6.
C.R. W, Ph.G. J, J. H, Rij A.M. Lipid peroxidation and malondialdehyde in the synovial fluid and plasma of patients with rheumatoid arthritis. Clin Chim Acta. 164:245–50.
7.
J.M.C. G, D.A. R, B H. Superoxide-dependent formation of hydroxyl radical in the presence of iron salts. Detection of “free” iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J. 199(1):263–5.
8.
C.I. L, J.J. A, C.J. P, C.J B. The activation of protocollagen proline hydroxylase by ascorbic acid in cultured 3T6 fibroblasts. Biochim Biophys Acta. 338:29–36.
9.
M. A, K. L, J. P, E K. Amino acid metabolism of experimental granulation tissue in vitro. Biochem J. 132:663–71.
10.
Meistner A. Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem. 269:9297–400.
11.
G.N. L, B. F, S.N. K, M.D. G, J.F. K, J.A V. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 93:1107–13.
12.
H.A. L, B. F, A.M. O, T.E. C, K.E A. Protection from oxidized LDL-induced leukocyte adhesion to microvascular and macrovascular endothelium in vivo by vitamin C but not by vitamin E. Circulation. 91:1525–32.
13.
J. P, T. S, R W. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature. 278:733–8.
14.
А РС. Рентгендиагностика заболеваний костей и суставов.
15.
Horvat M. Hrskavica rasta dugih kostiju u patološkim uvjetima. Acta Chir Yugosl. XVI:73–82.
16.
Atanacković M. Patologija kostiju i zglobova.
17.
H.J. S, R.J. F, S.H. Z, E. S, S. A, B. C, et al. The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal enzyme secretion for neutrophils. J Exp Med. 143:1154–69.
18.
Straus B. Medicinska biokemija.
19.
Turek S. Orthopaedics.
20.
P. B, Eijk H.G., A.J.G. S, J.F K. Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. J Clin Invest. 73:1576–9.
21.
S.K. J, D.M W. Reduced levels of plasma ascorbic acid (vitamin C) in sickle cell disease patients: Its possible role in the oxidant damage to sickle cells in vivo. Clin Chim Acta. 149:255–8.
22.
C.C W. Comparison of superoxide with other reducing agents in biological production of hydroxyl radicals. Biochem J. 182:625–8.
23.
Halliwell B. Oxygen is poisonous: The nature and medical importance of oxygen radicals. Med Lab Sci. 41(2):157–71.
24.
A. B, J.H. S, A.J T. Proton secretion by stimulated neutrophils. J Clin Invest. 74:455–9.
25.
S.J W. Oxygen, ischemia and inflammation. Acta Physiol Scand. 548:9–37.
26.
H.M. R, J.L. B, C.S. R, K.A. A, B.R S. Dynamics of leukocyte-platelet adhesion in whole blood. Blood. 78(7):1730–7.

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