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VITAMIN C CONCENTRATIONS IN SERUM BEETWEN PATIENTS SUFFERING FROM DIFFERENT FORMS OF NON-SPECIFIC OSTEOMYELITIS
.Institute for Biochemistry, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
.CHC Pristina, Clinic for Orthopaedic surgery, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
CHC Pristina, Clinic for Orthopaedic surgery, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute for Biochemistry, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute for Biochemistry, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
CHC Pristina, Clinic for Orthopaedic surgery, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Institute for Physiology, Medical Faculty Pristina , Kosovska Mitrovica , Kosovo*
Published: 01.12.2006.
Volume 34, Issue 2 (2006)
pp. 7-11;
Abstract
Bone tissue infections caused by non-specific agents (non-specific osteomyelitis) occur most frequently among children and young individuals demanding surgical and antibiotic therapy, although with unpredictable clinical outcome. While mobilization of cellular response to infectious agents takes place, a bulk of oxygen-derived free radicals emerge with concomitant participation of various elements of endogenous antioxidative defense. Vitamin C is an endogenous antioxidant active in the aqueous phase. It is very likely that ostoemyelitic patients already have some kind of disorder in specific antioxidant system due to hematogenic origin of non-specific osteomyelitis. Our results show that serum total vitamin C concentrations among patients with non specific osteomyelitis are not significantly different from those obtained among control subjects. However, we found significantly different concentrations of ascorbate, dehyroascorbate and their concentration ratio in serum within osteomyelitic patients that points to enlarged consumption of ascorbate even before the bone localization of infection took place
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