Current issue

Issue image

Volume 53, Issue 4, 2025

Online ISSN: 2560-3310

ISSN: 0350-8773

Volume 53 , Issue 4, (2025)

Published: 30.06.2025.

Open Access

All issues

More Filters

Contents

01.12.2006.

Original scientific paper

OCULAR CHANGES OCULAR CHANGES AT SERONEGA SERONEGATIVE ARTHROPATHY

Seronegative arthropathy represents group of rheumatic diseases which affects younger patients, more often male. Ocular findings are numerous such as conjunctivitis, iridocyclitis, and they are a part of extraarticular clinical manifestations. Acute anterior uveitis, as most common ocular manifestation, could be a sole or associated morbidity condition at the forme of systemic diseases

M. Mirković, V. Jakšiċ, L. Žorić, D. Vukša, D. Stamenković, S. Bulajić, Z. Petković

01.12.2006.

Original scientific paper

RECURENT ECURENT CHILDREN HEADACHES IN CHILDREN HEADACHES IN VOJVODINA

Among the Vojvodinian children aged between 3-16, 27,69% have recurrent headaches, 18,83% have nonmigraine and 8,63% migraine headaches. Children aged between 3-7 suffer recurrent headaches in 18,64%, 14,77% nonmigraine and 3,87% migraine. The presence of migraine headaches rises proportionally to aging, more significantly than the presence of non-migraine ones from 2,65% to 11,72% with boys, and from 2,71% to 15,86% with girls. The presence of nonmigraine headaches with children aged 3-16, grows proportionally to age, from 14,0% to 21,15% for boys, and from 14,36% to 24,84% for girls. Migraine with aura makes 25,55%, migraine without aura 67,21% and other migraine headaches 7,23% of the migraine syndromes

M. Knežević-Pogančev, V. Ivetić

01.12.2006.

Original scientific paper

PREGNANCY TERMINATION AT PRENATALLY DIAGNOSTIFIED FETAL ANOMALY: TWO PROTOCOL COMPARATION

Medical abortion (i.e. abortion induced by pharmaceutical agents) is a method of pregnancy termination administered most often in the second trimester in case of either fetal malformations or absence of fetal heart tones (missed abortion. Aim of the study was to compare effects of two regimens of drug adminstration for pregnancy termination in case of fetal anomalies registered in the second trimester of pregnancy. The investigation was performed in 52 patients of the Universitasklinik fur frauenheilkunde, Allgemaines krankenhaus (AKH), Klinische Abteilung fur Gynakologie und Geburtshilfe, Abteilung fur pranatale diagnostic und therapie and comprised two groups of patients in whom pregnancy termination was performed in the second trimester because of the presence of fetal malformations. Comparison analysis of the effect of the two regimens for pregnancy termination has been conducted in two groups of patients: Group A, who received R R R Cergem (Gemeprost) and Group B, who received a combination of Myfegine (Myfepriston) and Cyprostol (Misoprostol). Complete medical abortion occurred approximately at the same rate in both investigated groups (Group A - 10 (35.7%); Group B - 9 (37.5%). Curettage (Vacum aspiration) following the incomplete medical abortion was required in the group R R with Gemeprost in 18 (64.3%), and in the group with Myfegine /Cyprostol in 15 (62.5%) patients. A regimen of mifepristone pre-treatment followed by misoprostol applied in the Group B presented with financial benefits according to the present time prices of drugs in Austria relative to the regimen administered in the Group A, in which the cost of a single or a two-day treatment by gemeprost was significantly more expensive.

M. Bogovac, D. Bettelheim, G. Relić

01.12.2006.

Original scientific paper

FATS OF DIFFERENT ORIGIN IN NUTRITION AS A RISK FACTOR IN THE DEVELOPMENT OF CEREBRO-VASCULAR INSULT (STROKE)

The aim of the paper was to investigate whether nutrition based on animal fats in the group of patients who used them as dominant-group S ( the patients of Greek Orthodox creed), is a more signifikant risk factor in the development of stroke than nutrition based on vegetable fats-group A( the patients of Muslim creed). At the same time, the aim of the article was to find the parameters of lipid status which would define in a better way the connection between hypercholesterolemia and apoplexy. The research was done on 230 patients with ischemic CVI who underwent hospital treatment at the Neurological Clinic of the Clinical-Hospital Centre in Pristine. The patients at the Neurological Clinic of the Clinical-Hospital Centre in Pristine were divided into two groups: Group A (n=130)- the patients who based their nutrition mailnly on vegetable fats (the patients of Muslim creed) and Group S (n=100)- the patients who based their nutrition mainly on saturated fats ( the patients of Geek Orthodoc creed). It was stated that the intake of both vegetable and animal fats in larger quantities bears a risk of the development of the cerebra-vascular insult. The intake of saturated fats is a higher risk factor leading to the increased values of cholesterol, triglycerides and LDL-cholesterol in the group of patiebts of Greek Orthodox creed (group S) in comparison to the group of patients of Muslim creed (groupA).

G. Petrović-Oggiano, V. Damjanović, M. Pavlović, G. Ristić, M. Glibetić, R. Mitić

01.12.2006.

Original scientific paper

DOXYCYCLIN IN INHIBITION OF METALLOPROTHEASIS IN GONARTHROSIS

Gonarthrosis is degenarative knee disease as well as the commonest chronic knee arthropaty. Nowadays more attention is given to modern pathogenesis of arthrosis in two levels: 1. immunological; 2. some ferments disbalance phenomenon. In the second level of pathogenesis, a special atention is given to metalloprotheasis. The importance of doxycyclin on the reduction of metalloprotheasis in synovia has a great therapy importance not only theoretically but pratically as well 78 patients with primary and secundary gonarthrosis has been examined (19 men and 59 women) the appliance of doxycyclin in clinic elements common for gonarthrosis caused the improvemnt of all clinic parameters especially muscular strenght and pain, but the largest improvement was noticed in knee - joint circumference

S. Minić

01.12.2006.

Professional paper

EPIDMIOLOGY OF MECHANICAL EYE INJURES WITH INDICATION TO BE HOSPITALISED

In average 2% cases cause of blindness are mechanical injuries of the eye. This retrospective study was conducted in a 6 years period (from 1990 to 1995). Regarding to demographic data (74% were male with domination of children up to 6 years old of among age structure 151 patients, or 23%;The most numerous were pupils and students (247 or 37%).1% of patient were injured both eyes in the same time. The most common cause of eye trauma was wood (28%) and during the playing time (48%) and at home (27%). At 25 patients evisceration and enucleation were performed. Visual acuity was satisfied or good at 52% patients at the reception but on admission result was better: 68%

V. Jakšiċ, D. Vukša, D. Stamenković, L. Žorić

01.12.2006.

Original scientific paper

VITAMIN C CONCENTRATIONS IN SERUM BEETWEN PATIENTS SUFFERING FROM DIFFERENT FORMS OF NON-SPECIFIC OSTEOMYELITIS

Bone tissue infections caused by non-specific agents (non-specific osteomyelitis) occur most frequently among children and young individuals demanding surgical and antibiotic therapy, although with unpredictable clinical outcome. While mobilization of cellular response to infectious agents takes place, a bulk of oxygen-derived free radicals emerge with concomitant participation of various elements of endogenous antioxidative defense. Vitamin C is an endogenous antioxidant active in the aqueous phase. It is very likely that ostoemyelitic patients already have some kind of disorder in specific antioxidant system due to hematogenic origin of non-specific osteomyelitis. Our results show that serum total vitamin C concentrations among patients with non specific osteomyelitis are not significantly different from those obtained among control subjects. However, we found significantly different concentrations of ascorbate, dehyroascorbate and their concentration ratio in serum within osteomyelitic patients that points to enlarged consumption of ascorbate even before the bone localization of infection took place

D. Mirić, R. Grbić, A. Vasić, B. Božović, I. Dragojević, M. Marković, V. Nestorović

01.12.2006.

Original scientific paper

EHOCARDIOGRAPHIC CHARACTERISTICS OF LEFT VENTRICLE IN NON-Q ACUTE MYOCARDIAL INFARCTION

In this work we have examined echocardiographic characteristics of left ventricle in patients with acute myocardial infarction (AMI). We used prospective study, during 12 months, and we followed 55 patients with diagnosed non Q AMI. All patients were hospitalized in the Coronary unit. Results: 55 consecutive (40 males middle age 55,4±8,7 and 15 females middle age 57,4±10,3) had non Q AMI. Value of ejection fraction: after 4.day - 50,4±6,2% ,2.weeks - 54,6±5,8%, 4. weeks - 59,3±5,4%. Value of ejection fraction in patients with thrombolytic therapy: 61,6±6,8% vs. 57,3±6,6% p> 0,05;Value of left ventricle fractional shortening: 28,8±2,5% (in patients with thrombolytic therapy 30,3±4,8% vs.27,2±5,9%) Value of end2 2 2 - diastolic volume: after 4.day- 62,5±5,3 ml/m , 2.weeks - 63,1±5,4 ml/m , 4. weeks - 64,4±5,8 ml/m (in patients with throm 2 2 2 bolytic therapy 60,5±9,2 ml/m vs. 67,4±8,4 ml/m ) Value of endsistolic volume: after 4. day - 26,2±2,1 ml/m , 2.weeks2 2 26,8±2,3 ml/m , 4. weeks - 27,6±2,2 ml/m (in patients with thrombolytic therapy 25,6±2,8 ml/m2 vs. 31,7±3,1 ml/m2 p> 0,05). During the in-hospital follow up period, 2(3,6%) patients and during the post-hospital follow up period, 1 (1,9%) patients with non Q AMI had lethal outcome.

S. Sovtić, S. Tomić, V. Trajković, A. Jovanović, Z. Marčetić, V. Perić, R. Stolić, T. Novaković, S. Lazić, S. Pajović

01.01.2006.

History of medicine

RELATIONS OF THEORY, STRATEGY AND TACTIC IN PREVENTIVE MEDICINE TYPHUS ENANTHEMATICUS IN SERBIA IN 1914/15 R

Synonym Louse borne typhus represents the connection between Typhus exanthematicus and body lousiness. The results of the experiment Nicolle 1909 definitely established that. It is not explored how well the fact that Typhus is transmitted by body lice was known by doctors who were the actors of events in Serbia in 1914/15 year. A number of them categorically stated that they weren't aware of the results of Nicolla's experiments. Those honest doctors accused themselves that the fact not knowing made that “people paid by several hundreds of heads”, it was concluded that “they didn't know the theory and practice of Typhus epidemiology”. They thought that the epidemic disease would have had another direction if that had known that fact. In 1914/1 Serbia was “Typhus land stomach, recurrent and mysterious and violent Typhus”. It was the place where hypothesis “that destroying lice could be adequate proceeding in repress epidemic of Typhus” could be checked. On the epidemic culmination there was no any act or mean for effective total massive destroying lice. Disinfestations were the hygiene measure until 1915 year, and that wasn't anti epidemic measure. The working aim is to show the paradoxes: of doctors' self-accusing and confirmation on existing of special measures against Typhus. Descriptive method. Inspection in: professional, historic, fictive, accounts of its travels reviewers and archive origin on Typhus in the First World War. In 1914/15 there was no special epidemiology of Typhus. There was no effective tactic mean for massive disinfestations. Until then, nobody was stopping epidemic of Typhus bys strategy of destroying lice and their eggs. They didn't completely trusted Nicolla because current authorities believed that Typhus could be transmitted also by droplets' way. In the actual moment of epidemic culmination, the public's opinion was that disinfestations would be successful. Self-accusing of national doctors appeared after the success of English military mission. Kujachitsh was writing about Nicolla's experiments and he was a participant in war in 1914/15 and so he didn't look for a disinfestations (depediculation) mean and he didn't also strictly expressed himself on lice importance. Hirschfield, Subotitsh were looking for a mean for massive disinfestations; according to the results, they weren't successful. Scientific theory of Nicolla, and its prompt review by Kujachitsh, might be the base for positive movements, but also for tendentious “inflaming imagination” - “what could be if…”. We'll support the opinion how (the most) rationally the success could be reached: 1) what was cumulatively hypothetic by proofs becomes cumulatively confirmed; 2) supporting better stages in reaching the truth. Further appearance of sick could be added to failure: a) of tactic solution; or/and b) a strategy; or/and even solidly proved c) start, experiment of Nicolla. Interdependence is maximal first not proved conditions that the following one is problematic. There were no intention to prove that “disinfestations was successful for eradication of Typhus”, and from that appeared the failure of chosen mean, organisation of proceeding and so on, it could influence valuation of strategic result, instead of having reliable knowing on disinfestations power as a motive for finding means. The fruit of the projection and emotions is a prejudice that Nikola's theories is self-sufficient in order to make epidemic resulted in significantly less number of victims from Typhus if that had been known because all of the rest would be just result; that Stammer's mean could be easy to find. All of this produced repentance and self-accusing a number of honest doctors and that was stressed further, and it was never put under consideration although it came only after final happening. Successful tactic solution was uncertain if it was going to be found at all. Ranges of tries were not successful (Subotitsh, Hirschfield and so on). Stammer's “Serbian barrel” was enough for stopping dangerous large epidemic scale. Hunter had a planned approach to eradicate Typhus by disinfestations (depediculation), he applied that new strategic measure in the whole territory of Serbia, in: the Army, national and displaced population, as well as among the prisoners. Mostly thanking to Nicolla, only after epidemic in Serbia in 1914/15 the adequate synonym to Typhus is “Lousy Typhus”. The special epidemiology of Typhus was not constituted until 1919, and so
the valuation of not knowing the theory and practice (of special epidemiology) of Typhus was not applicable to time in 1914/15. There are no guilty ones for death of Typhus in Serbia in 1915 among the doctors. Informing that lice transmit Typhus meant that in looking for disinfestations procedure “there was no more in obligation, but more in opportunity”. Success of Stammers classifies himself among the “unusual” ones. Success of English military mission with Hunter on the top, made that Golgotha exceeded into epopee. The typhus from then always used to lose its battle.

G. Čukić

01.12.2006.

Original scientific paper

QUALITY QUALITY AND EFFICACY AND EFFICACY OF A TELECOLPOSCOPY TELECOLPOSCOPY PROGRAMME PROGRAMME

We tested the performance of telecolposcopy in the diagnosis of various squamous intraepithelial lesions. There were three groups of physicians: Group 1 consisted of 15 gynaecologists who were not trained in colposcopy; Group 2 consisted of six experienced colposcopists (specialists); Group 3 was a supervising team constisting of three experts (colposcopists with more than 15 years of colposcopy experience). The first group took colpophotographs during gynaecological examinations and used a Web browser to compare them with examples from a database of colposcopy findings. Group 2 made their own diagnoses independently. Then the supervising team examined the findings from all 250 patients and made diagnoses that could be considered the ''gold standard''. The findings were identical for Groups 1 and 2 in 219 cases, i.e. an inter- observer agreement of 88%; Cohen's kappa was 0.81. The findings were identical for Groups 1 and 3 in 208 cases, i.e. an inter- observer agreement of 83%; Cohen's kappa was 0.74. The findings were identical for Groups 2 and 3 in 239 cases, i.e. an inter- observer agreement of 96%; Cohen's kappa was 0.93. There was high inter- observer agreement between all participants. However, there were also significant differences in some cases. In the cases of suspected invasive carcinoma, 2 the results showed a significant difference (x =4.8, p < 0,005) because gynaecologists from Group 1 were not sure of their diagnosis and they wanted to obtain a second opinion by referring the decision to a higher level.

Ž. Perišić, D. Vukićević, N. Perišić, A. Egić, L. Tasić

Indexed by