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Volume 53, Issue 4, 2025

Online ISSN: 2560-3310

ISSN: 0350-8773

Volume 53 , Issue 4, (2025)

Published: 30.06.2025.

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01.01.2009.

Original scientific paper

THE EFFECT OF VERAPAMIL ON TRACHEA RESPONSE CAUSED BY HISTAMINE AND ACETILCHOLINE

In the study with experimental animals in vitro conditions, the aim of the research was to examine the effect of verapamil on the even brawniness of the isolated organ of the respiratory ways (tracheas) in guinea-pigs on acetylcholine and histamine, and in that way, to examine local mechanisms of smooth muscle system but also to exclude the rest of the neurohumoral influences. The guinea-pigs of both sexes (average weight of 500-700 gr), were used for this experiment. 10 guinea-pigs were included in the experimental research; the trachea was taken from them after the immolation. The preparations of isolated organs of trachea were divided into two groups (A and B). The previous incubation of trachea -5 isolated by verapamil (1 minute) in concentration 10 M significantly reduced the contraction caused by acetylcholine -4 (ascent 21.49±9.63, r=0.97, p<0.05). Concentration of verapamil 10 M also caused significant fall of contraction (ascent -5 21.3±12.63, r=0.95, p<0.05). Verapamil in concentration 10 M significantly reduces the response of isolated trachea cau- -6 -5 -4 sed by histamine in concentrations 10 M and 10 M (slope 21.3±10.6, r=0.96, p<0.05).Concentration of verapamil 10 M significantly reduced the contraction of smooth muscles of isolated trachea caused by histamine (slope 15.46±10.47, r= 0.94, p < 0.05).

R. Mitić, B. Biševac, Z. Stanojević, M. Bursać, T. Đokić

01.01.2009.

Original scientific paper

FLOW/ PRESSURE AND FLOW/ VOLUME CURVES IN DIFFERENTIATION OF THE OBSTRUCTIVE CHANGES IN TRACHEOBRONCHIAL TREE

Conducting research in the field of respiratory function, by using measuring and testing, has many purposes. First of all, it could show us how lungs function as a whole, but also, it could lead us to the exact location of a disorder. The aim of this paper is to, by employing accurate correlation of the measured variables of the flow/volume and flow/pressure curves, determine the location of the obstruction process in the tracheobronchial tree, in central-upper airways, as well as in a segment of small airways, so called 'silent zones' of the lungs, smaller than 2 mm in internal diameter. This research included 115 healthy people and 106 patients with chronic obstructive lungs disease, of both genders. The following values of the measured lungs' function parameters were found among healthy people (% of predicted value): FVC- 93%; FEV - 91,1 %; 1 FEV x 100/ FVC- 98,7%; MEF - 107,9%; MEF - 87,5%; MEF-98,9%; Rt-147,1%; ITGV-103,3%; SRt- 130,7%. 1 25%FVC 50%FVC Among the patients with chronic obstructive bronchitis, the following results of the examined parameters were gained: FVC- 66,3%; FEV - 54,2%; FEV x 100/ FVC- 80,7%; MEF - 19,3%; MEF - 23,1%; MEF- 40,5%; Rt- 51,2%; 1 1 25%FVC 50%FVC ITGV- 162,1%; SRt- 36,2%. Finally, there was a certain number of the healthy examinees who showed that direct indicators of the air flow resistance (Rt, SRt) were not significantly changed, while indirect indicators of the respiratory tracts obstruction (MEF , MEF ) were reduced, comparing to the expected tabular results.

N. Matinić, Lj. Popović, M. Mirić, T. Đokić

01.01.2009.

Professional paper

OCULAR CHANGES OCULAR CHANGES AT SERONEGA SERONEGATIVE ARTHROPATHY

Seronegative arthropathy represents group of rheumatic diseases which affects younger patients, more often male. Ocular findings are numerous such as conjunctivitis, iridocyclitis, and they are a part of extraarticular clinical manifestations. Acute anterior uveitis, as most common ocular manifestation, could be a sole or associated morbidity condition at the forme of systemic diseases.

M. Mirković, V. Jakšiċ, L. Žorić, D. Vukša, D. Stamenković, S. Bulajić, Z. Petković

01.01.2009.

Professional paper

HISTOPATOLOGICALAND CLINICOMORPHOLOGICAL CHARACTERISTICS OF MALIGNANT TUMORS OF THE SKIN

Malignant tumors of the skin (MTS) are between the most common malignant tumors at human population. Because of their similarities, and more important, their dissimilarities, it is very important to determinate histophologycal type, grading and staging, because they are the most important factors of therapy choise and prognosis. The aim of our work was to examine those parameters, and also to define sex, age and locations distribution, as well as the value of surgical treatment. We analysed biopsy material of Institute of pathology, Medical faculty Priština from 2004-2007. year. We found that squamocellular carcinoma (SCC) and basal cell carcinoma (BCC), and malignant melanoma (MM) were more common at older persons, about 2x more common at male, little bit younger at persons with BCC and MM than SCC. The most common location was skin face; at persons with SCC and BCC significant more common than on all other skin locations. SCC was more common below, and BCC was more common on skin face above imagine line from tragus to the same side lips corner. Average size was about 1,5 cm, and macroscopic they were ulcerous, verrucous and infitrative. Invasive SCC was diagnosed in 2/3 cases in the most early stadium. In opposite MM was diagnosed in late stadium in majority cases. Moderate inflammatory infiltrate was found in most cases of all MTS. MTS was adequate removed in the most part cases.

M. Vančentović-Mijović, N. Mitić, D. Vukićević, Z. Dolićanin, B. Đerković

01.12.2009.

Original scientific paper

FEET DEFORMITIES AMONG CHILDREN AS A NEGATIVE IMPACT FACTOR ON RUNNING ABILITIES

The aim of this study was to determine the functional state of the feet of 40 boys aged 12 and 6 moths up to 13 and 6 months and by using the criterion variable of the 500 m run, to carry out a comparative analysis of their running speed. The subjects were divided into three groups: group I which numbered 14 boys with normal feet, group II which numbered 14 boys with high arches (pes excavatus) and group III numbering 12 boys with flat feet (pes planus). The diagnosis of the feet conditions was made following the inspection of the Achilles' tendon and the medial edge of the foot, followed by a plantogram. The statistical analysis of the results from the 500 m run was carried out by means of basic statistics, the analysis of variance (ANOVA) and the Ò criterion used to determine the source of the variability while testing the normality of the distribution. The analysis of the obtained results led us to the conclusion that foot deformities represent a negative factor for the ability to perform the 500m run which is one of the requirements in the battery of tests used in elementary schools. The analysis of variance, ANOVA, has indicated that there are significant differences between the boys in terms of their results for the 500 m run (p=.00). The difference between the average running time of the boys with normal feet and the boys with high arches is not statistically significant, while the differences between the average results of the run for the boys with normal and flat feet, as well as between the boys with high arches and flat feet are statistically significant, which led us to the conclusion that flat feet have a greater negative impact on the running ability than high arches. We can assume that boys with feet deformities (especially the ones with flat feet) will probably be less physically active than boys with high arches, which also leads to their significantly weaker running abilities. 

V. Stanković, Lj. Jovašević, D. Toskić, N. Đukuć-Macut

01.12.2009.

Original scientific paper

THE STATE OF ALIMENTATION IN PUPILS OF 3rd, 5th AND 7th GRADE IN SERBIAN ENCLAVES IN KOSOVSKO POMORAVLJE IN 2008/2009.

670 students, of 3rd, 5th and 7th grade, were examined. 50,6% were boys, 526(78,51%) healthy (3<PB<90), that is well nourished students, (257-38,36%) boys and (269-40,15%) girls. There is statistically significant frequency of normally nourished children of 3rd, 5th and 7th grade in comparison to the whole frequency of appearing of the numbered eating disorders (p<0,001). Undernourished (PB) were 18 students (2,68%), 9 boys (1,34%) and 9 girls (1,34%). Malnutrition is statistically the least frequent eating disorder with children of 3rd, 5th and 7th grade. Pre-obese (90<PB<97) were 92 students (13,73%), where 47 were boys (7,01%) and 45 were girls (6,72%). Pre-obesity is statistically the most frequent eating disorder among children of 3rd, 5th and 7th grade (p<0,05). 34 students (5,07%) were diagnosed with obesity, 26 (3,88%) boys and 8 (1,19%) girls. Statistically the obesity appears more often with boys than with girls of the same age (p<0,001). In general the least manifested eating disorder with students of 3rd, 5th and 7th grade, but also in each class separately, is undernourishment, which appears with the same frequency both with boys and girls. Generally the most manifested disorder in nourishment with students of 3rd, 5th and 7th grade, but also in each class separately, is pre-obesity which appears with the same frequency both with boys and girls. The level of obesity is the highest with the students of 3rd grade, and the lowest with the students of 5th grade.

S. Milutinović, M. Milanović, J. Živković, Z. Dimeski

01.12.2009.

Original scientific paper

ANTHROPOMETRIC PARAMETERS IN DETERMINING THE SIZE AND DISTRIBUTION OF FAT MASS IN SUBJECTS WITH METABOLIC SYNDROME

Metabolic syndrome is a common metabolic disorder whose primary feature is abdominal obesity, which is associated with a high prevalence of dyslipidemia, hypertension and glucose tolerance disorders. The goal was, determine BMI in subjects with metabolic syndrome and people with normal body weight, take anthropometric parameters (waist and hip circumference, and calculate WHR and WSR index) to assess the average degree of nourishment and body fat distribution. The research was conducted in Gracanica Health House. The study group consisted of 130 subjects that met the criteria for metabolic syndrome. The control group consisted of 40 randomly selected subjects during medical check-ups. The study group was dominated by female with 83. 08%, followed by 16. 92% of male subjects, with the average age of subjects being 56. 32 years. The average BMI index of the study group was 32. 22 kg/m², which indicates first-degree obesity, while the average BMI index of study group subjects was 24. 67 kg/m², which is within the normal nutrition range. By comparing the average values of anthropometric parameters, we established that the study group subjects had statistically significantly higher average body weight parameters (waist-to-hip ratio p<0,001), while the control group subjects had a higher average of body height (p<0,001). In both, study and control group, male subjects had a normal WHR, which is not the case with women. Therefore, there was a statistically significantly higher number of women with pathological WHR (p<0,001) than of men in both groups. The study group had a statistically significantly higher number of subjects with pathological WHR (p<0,001). The average WSR value (waist/BH) is statistically significantly higher in the control group (p<0,001). Obese individuals had significantly higher values of measured anthropometric intraabdominal fat indicators compared to normally nourished people. 

B. Inić Kostić, T. Novaković, S. Milinić, R. Trajković, N. Đokić, S. Nikolić

01.12.2009.

Professional paper

SATISFACTION OF THE EMPLOYEES IN THE GENERAL PRACTICE SERVICE OF THE HEALTH CENTRE NOVI SAD

A survey was made among the employees of the Health Centre Novi Sad. It included 237 people, of which 99.6% were health workers and 0.4% administrative workers. Among the respondents 8.4% occupied a managing post. The questionnaire included the issues relating to the satisfaction of the employees with working conditions, work-associated fatigue, comparison of the job satisfaction five years ago and now, plans for the next five years, and overall job satisfaction. Based on the answers of the respondents it comes out that only 36.3% of the health workers are satisfied and very satisfied with their jobs, which is a very small percentage regarding the nature of the work they do. However, 42.2% of health workers plan to remain in the public sector in the next five years, and 41.8% do not even think about changing the job. This was logical to expect bearing in mind the material position of the health care and overall economic situation in the society. 

M. Vojnović, R. Doder, M. Ban, J. Kolarović

01.12.2009.

Professional reviews

PHYSICAL-TECHNICAL PRINCIPLES OF COMPUTERIZED TOMOGRAPHY

Theoretical principle of computerized tomography was set by Czech mathematician J. Radon in 1917.The development of computerized tomography is connected with the name of A.M Cormack who, in 1963, started with the research directed at X-ray beam intensity measurement after passing through certain substance.First computerized tomography appartus was installed in Atkinson-Morley hospital in October in 1971 in London. Computerized tomography is based on making transverse(axial) cross-section of body parts,by X-ray beam passing through visible body part and by measurement of X-ray absorption degree using detectors. A cross-section picture of certain body part is obtained on a monitor as a final result of CT examination. A system of picture digitalisation and application of grey scale concept is particularly complex. Basic elements of CT are gentry, patient's bed, high-voltage generator, working and computer console, system for transferring picture on a film or other electronic media. Densimetric tissue values can be measured on the obtained CT picture. A change can be isodense, hypodense or hyperdense. Density change is expressed in Hounsfield units. Contrasting remedies can be applied, during CT, intracanalicular or intravenous. A better quality survey of changes increasing tissue density is obtained using them. CT application is indicated in diseases such as:neurocranium, visceral cranium, spinal column, thorax, abdomen, skeletal, joint and muscular system. X-ray side effects and precaution risks are being described in the text.

T. Jovanović

01.12.2009.

Professional reviews

ADIPOKINES AS FOR RUNNERS OF INFLAMMATORY CITOKINE SUPERFAMILY AND ITS INVOLVEMENT IN INFLAMMATORY AND IMMUNE DISEASES

Leptin was discovered in 1994, finding, that marked the beginning of a new understanding about white adipose tissue. Up to end of 20th century this tissue was viewed as an inert tissue, devoted to body protection from heat loss and to passively store energy. This static vision, changed with identification of the product of the gene obese (ob) wich accentuated the role of adipose tissue in the physiopathology of obesity-linked diseases, and led to the discovery of various adipokines, many of a pro-inflammatory nature. With emerged knowledge of (WAT)-derived adipokines, it is obvious that they can be now considered as the bond between obesity-related environmental causes, such as nutrition and lifestyle, and the biochemical shifts that lead to metabolic syndrome, inflammatory and/or autoimmune conditions, and rheumatic diseases. This paper deals with reviews of recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases.

Lj. Smiljić, M. Radunović, M. Muratović, T. Smilić

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