Metformin is an anti-hyperglycemic agent used for the treatment of type 2 diabetes mellitus. Biguanides lower blood glucose levels primarily by decreasing the amount of glucose produced by the liver. Metformin also helps to lower blood glucose levels by making muscle tissue more sensitive to insulin so glucose can be absorbe. The purpose of the study was to establish the effect of metformin on insulin secretion in obese patients with newly diagnosed diabetes mellitus type 2. We included 40 patients with Type-2 Diabetes Mellitus, who were treated on Department for Internal Disease in Hospital King Milutin Laplje Selo. Patients included in the study were newly diagnosed with diabetes mellitus type 2, glycemia < 12 mmol/L, and hed the Body Mass Index >30 kg/m2. They were treated with metformin, 1000 mg/day. Insulin sensitivity was determined by HOMA IR, insulin secretion by HOMA, lipid status by spectrophotometry. After six months of treatment blood biochemistry tested again. BMI was also established. Metformin significantly lowered BMI (BMI before therapy 31.02 kg/m2, after treatment 28.7 kg/m2) (both p<0,001 vs baseline) waist circumference mean value 98±0.55 cm-93,12 cm. (p<0,001) During the therapy the glycaemia decreased from 11.7 mmol - 6,78 mmol/l, insulinemia mean value 20.141 mlU/l -13.691, HOMA IR elevated in all patients. Among the cholesterol fractions, most significant results were obtained in LDL cholesterol. Mean LDL cholesterol levels 4.51± 2.02 mmol/L. Mean cholesterol level 6.98±2.31 mmol/L. HDL levels -1.32 mmol/L. Serum triglycerides was (mean) 2.63±1.32mmol/L. After six months therapy Metformin produces beneficial changes in lipid states. Metformin may be the first therapeutic option in the diabetes mellitus type 2 with overweight or obesity. Metformin produces beneficial changes in glycemia control, and moderated in weight, lipids and insulinemia. 

Evaluation of population health condition is a basic mode of collecting health condition and health needs data of a population. Evaluation of population health condition is a base of contemporary health care and health service as well as health improvement and further health system development. In order to gain information on all (physical, psychological and social) health aspects, one has to go beyond health care system and consider objective health condition indicators gained by routine health statistics along with subjective information for creation an image of health condition, that is to say data collected from citizens themselves. This is significantly important when health condition data are sparse, as this is the case with health marginalized groups such as refugees and displaced persons. Value of data collected in this way is in the fact that they refer to determinants defining health, such as social-economical status, life style, education, employment, quality and availability of health care. The aims of this research is to establish how refugees, housed in refuge camps in the North Kosovo and Metohija, evaluate their health and what are the most common health problems of this population. The research was undertaken as a study of a standard representative sample of the adult refugees housed in the refuge camps in the North Kosovo and Metohija. It involved 109 surveyed people. The questionnaire, used for Health Examination in the Republic of Serbia adapted to local conditions, was utilized as a research instrument. The data were processed by descriptive statistics methods 2 and ÷ test was used in the means of data analyzing. More than a half of the surveyed (55.1%) answered that their health condition was good and very good. There is a great difference in health self-evaluating regarding age, marital status, education, the year when they arrived to current domicile. Less than two thirds (65.2%) of the surveyed in the refuge camps in North Kosovo and Metohija claimed that they suffer from some mentioned chronic illnesses. 

Chemical injuries of the eye i.e. causoma means 4% up to 10% of all ocular trauma cases. Purpose: to determinate basic socio-epidemiologic characteristics of patients who has been hospitalized due to causoma. Method: prospective case control study carried on 54 patients who havå been treated at Department of Ophthalmology Health Center K.Mitrovica and Clinic of Eye Disease in Nis. Results: in total, 40 male and 14 women were injured (mean age 41.8 years). The bricklayers, painters and construction-workers are the most frequent injured. Injuries caused by alkalis were significant prevailing in relation to those caused by acids (64.8% vs. 35.2). Monocular causoma were almost twice more frequent. Accident as a manner of injury was in 96.3% of all cases. Men were injured by caustic lime and sulphuric acid while women were injured by sodium hydroxide, hydrochloric acid and acetate acid. More serious clinical appearance had a patients with injuries caused by explosion of accumulator because of associated mechanical injuries of the eye.

Arrhythmogenic right ventricular dysplasia (ARVD) is a myocardial disease, often familial, that is characterised pathologically by fibrofatty replacement of the right ventricular myocardium, and clinically by ventricular arrhythmias of right ventricular origin which may lead to sudden death, mostly in young people and athletes. The term "dysplasia" was originally used to describe an entity that was considered to be the result of a developmental defect of the right ventricular myocardium.

Degenerative diseases are no inflammatory diseases intervertebrales discus, joints and ligaments vertebrae with subsequent changes in the bony spine structures. Degenerative diseases are very common and lumbar syndrome is most of them common. Because large disability that gives not only a medical but also social and economic problem. Starting of these facts here, work is set purpose,to the overall context of the diagnosis,differential diagnosis of degenerative lumbar sindrom. This is a complex problem that requires a great effort, expertise and modern diagnostic procedures in clinical rheumatology, which is outstanding problem in practice. We hove processed 55 patients with chronic low back pain and 20 patients with chronic low back pain and other etiology. With history, clinical examination, laboratory analysis, Rtg recordings,and other additional analysis (EMG,CT,MRI) that dodge tried to make the diagnosis and successful treatment.

The combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting, but also can cause serious hematological side effects. The purpose of this study was to evaluate the effect and interactions aspirin and ticlopidine on hematological variables. Thirty two Wistar rats were divided in four groups and they received intraperitoneal one of the following treatments for 4 days: group I - control, group II aspirin (50 mg/kg BM), group III - ticlopidine (125 mg/kg/day) and group IV - aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day). Hematological variables were determined at once after taking the sample of blood. Relationship between measured variables was determined by calculating linear correlation coefficient (r). The hematocrit, haemoglobin and red blood cell were significantly decreased in group treated with aspirin+ticlopidine combination compared to control (p< 0,05). Neutrophil and platelet count weren't significantly different in treated groups, but were slightly decreased in groups treated with ticlopidine and aspirin+ticlopidine combination. Between hematocrit and platelet count in control group of rats was noticed negative and medium correlation (r=-0,41), in groups treated with ticlopidine and aspirin+ticlopidine combination positive and medium correlation (r=0,52; r=0,69). Based on obtained results it can be observed significant decreased hematocrit, haemoglobin and red blood cell in group treated with aspirin+ticlopidine combination. The negative correlation between hematocrit and platelet count in control group becomes positive after the treatment with ticlopidine alone and aspirin+ticlopidine combination.

Without a knowledge of how drugs are being prescribed and used, it is difficult to suggest measures that would support rational use of drugs and improve prescribing habits in hospitals. In our work we analyzed utilization of antibiotics for systemic use at the Surgical Clinic of the Clinical Hospital Centre - Pristina in Gracanica in 2007. and 2008. on the basis of dispensing records of drugs issued from the Central Pharmacy to the Surgical Clinic for those two years. Antibiotics were distributed according to ATC classification, and antibiotics' utilisation was expressed in number of defined daily doses used per 100 patient-days (DDDs/100 PD). We analized qualitative and quantitative participation of different groups of antibacterials for systemic use. Òhe results of our study were in accordance with available results of similar studies in our country and in the neighbouring environment

Doppler ultrasound check-up significantly increases a possibility of initial functioning of arteriovenous fistula. The aim of the study was the preoperative evaluation of vascular system of the extremity for creation of arteriovenous fistula for haemodialysis. The examination was organized at Urology and Nephrology Clinic, Clinical Centre "Kragujevac". The examined subjects were 87 patients, 52 (59,8%) male and 35 (40,2%) female, mean age of 61±11,1 years. There were performed the routine biochemical analyses, demographical structure and clinical characteristics (type of anastomosis, fistula placement, arterial blood pressure, lumen size of the artery and vein, measured intraoperatively by Doppler technique). In 72,1% of patients with functioning fistula there was made a terminal-lateral anastomosis, compared to 57,7% of patients with initial non-functioning fistula, there was found a statistically significant difference between the groups p=0,008. Radiocephalic fistula was created in 62,3% of the examined patients with initial functioning , in patients with non-functioning, the distal fistula was created in 38,5% of the examined patients. Regarding the type of the fistula location there was obtained statistically significant difference; p=0,04. There was found a statistically significant difference between the group of patients with initial functioning of arteriovenous and the group without, concerning the intraoperatively measured lumen of the cephalic vein (2±0,29 vs. 2±0,38 mm); p=0,03 (2,1±0,5 vs. 1,8±0,4); p=0,0009. Statistical significance between the groups was also found in the lumen of the cephalic vein verified by the ultrasound (2,1±0,53 vs. 1,8±0,25 mm); p=0,038. Peak of the systolic speed of the radial, corelated to the group of patients with and the group without initial functioning fistula (50 ± 12,42 vs. 40 ± 6,9 cm/sec); (p=0,0026), has statistically significant value. By the correlation of the group of patients with initial functioning and the group of patients without initial functioning, regarding hemoglobin (97 ± 16,1 vs. 88 ± 18,3 g/l); p=0,006 and the level of urea (22,6 ± 12,7 vs. 23,9 ± 9,8); p=0,02, there was found a statistically significant difference. Color Doppler ultrasound has an important role in preoperative evaluation of blood vessels and it represents a meaningful predictive parameter of functioning of arteriovenous fistula. 

Biological equality assessments are carried out by means of: a) comparative pharmacokinetic study; b) comparative pharmacodynamic study; c) controlled comparative clinical experimentation; d) comparative in vitro assay (dissolution test). The first method mentioned, i.e. determining the concentration of a drug in the blood of healthy volunteers, is the most accurate and most frequently employed. In this paper, a study conducted on healthy volunteers that displays the possibility of evaluating biological equality using pharmacodynamic variable data, giving the example of such assay of retard tablets of verapamil produced by two different companies, is presented. Taking into account the effects of this drug, biological equivalence was proved by comparing pharmacodynamic variables such as PR interval, systolic and diastolic blood pressure and heart rate.

Background: In hernia inguinal regions that are usually on the front wall of the belly may appear epigastric, umbilical and postoperative (incision-ventrale) hernia. Incision (postoperative-ventral) hernia is the kind of hernia that occurs in the area before surgical incision made through the entire thickness of the abdominal wall. Purpose: The aim of this paper is to indicate the frequency incision, epigastric and umbilical hernia, and the validity of some methods used in surgical treatment. Materials and methods: The making of the material used Surgical Clinic KBC Pristina in Gracanica. This prospective study we included 107 (3.43%) patients with hernia abdominal front wall, which were operated in the Surgical Clinic from 2003- 2009th year. Results and discussion: the anterior abdominal wall hernia, are recorded in 48 (44.86%) male patients and in 59 (55.14%) female patients. Age is of great influence on the frequency of anterior abdominal wall hernia, because we have the largest number of hernia 45 (43.14%) recorded in patients older than 61 years. Free hernia we found in 68 (63.55%) and hernia incarcerate of 39 (36.45%) patients. Incision (postoperative) we found a hernia in 44 (41.12%), umbilical in 36 (33.65%) and epigastric of 27 (25.23%) patients. Postoperative hernia is most often occurring after longitudinal laparotomia. We have them registered in 19 (43.18%) patients with infraumbilical, in 10 (22.72%) with supraumbilical, in five (11.36%) with subcostal, with four (9.09%) with transrectal, at two (4.55%) with pararectal laparotomia, in two (4,55%) patients after lumbotomia made with two (4,55%) after Phanensthil incision. The treatment of the anterior abdominal wall hernia in 72 (67.21%) patients, we used prolen net, while in 35 (32.79%) patients made plastic abdominal wall. Drainage was used in 62 (57.94%) operated patients. In 78 (72.90%) patients applied the prophylactic dose of antibiotics, while in 29 (27.10%) patients applied therapeutic dose. The length of treatment of patients who applied prophylactic dose of antibiotics was 2.48 days and length of treatment of patients with therapeutic dose applied was 4.82 days. Prospective studies of patients in the postoperative complications are recorded in four (3.74%) patients. We had wound infection in two (1.87%) and recidive hernia in two (1.87%) patients. Conclusion: This surgical method, when it comes to herniotomia, a direct comparison with the number of postoperative recurrence. Implantation of mesh has found its place and it is a revelation in the resolution of abdominal wall hernia.