In the region of the thorax there are ten till twelve ganglia (ganglia thoracica); wich are white; triangle and irregular shape; rarely fusiform (spindle-shaped) or round. In the upper part of the thorax; ganglia are located in front of of the neck of ribs (collum costae); and in the middle part they are in front of head of ribs (caput costae). In the lower parts; they are near the vertebral bodies; therefore both of the trunks are slightly convergent. In this part; there are no branches which connected both sides of the sympathetic trunk. Lipofucin is yellow-brown; autofluorescent pigment; accumulated during aging in the lysosome of postmitotic cells; such as neurons.

Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of study is to define the relationship between efficiency topiramate in control of epileptic seizure and the apperance of cognitive adverse events. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatment took place on the Institute of neurology Clinical center of Serbia. The efficacy of treatment was estimated as the ratio of the total number of seizures during the last two months before the introduction of topiramate (on basic antiepileptic therapy) and during the last two months on stable (200mg/day) dose of topiramate.All patients are neuropsychological tested twice. First time before the start of therapy with topiramate, and next time two months after the achieving of stable dose. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. Patients with good success of topiramate in control of the seizures had worse scores on cognitive measurements than patients in whom topiramate was not demonstrated efficacy in treating epileptic seizures. Our findings indicate that the appearance of cognitive adverse events of topiramate possible in patients with reduction of seizure after the introduction of drug. This suggests that the same mechanism topiramat achieve a positive therapeutic effect and adverse effect on cognition in people with epilepsy.

Dermatoglyphs are epidermal ridges on the volar surfaces of fingers, toes, palms and soles.Their development begins between 6th and 7th gestational week, so that critical stage of ridge differentiation occurs in the first trimester, coinciding with critical phase of embryonal development. The inheritance of epidermal ridge patterns is polygenic, often markedly affected by some environmental factors causing them to be reffered as multifactorial traits. Genetic determination, time of occurrence, stability and high individuality enable dermatoglyphic analysis to give an insight in critical stage of embryogenesis. Unusual dermatoglyphic variables are found to be significant markers in many numerical and structural chromosomal aberrations .Many investigations have proved epidermal ridges configuration analysis as a powerful additional screening method in identification of congenital anomalies, detection and prevention of different genetically caused disturbances.

Type 2 diabetes represents a progressive disease, primarily characterised by impairment of glycoregulation, despite the application of various therapy modalities. The main problem with type 2 diabetes, is progressive impairment of betacell functioning, and impairment of insulin resistance. There is an ongoing pursuit after adequate therapy modalities aiming at preservation of beta-cell function followed by loss of weight and assurance of good glycoregulation. For mentioned reasons, research has been done recently on the functioning of enteropancreatic axis in type 2 diabetes. It has been noted that oral intake of food or glucose leads to higher increase in secretion of insulin in comparison to the intake of the same quantity of glucose intravenously, resulting in assumption that hormone signals from endocrine cells of intestine released by the intake of food represent potent stimulators of insulin secretion. Such role is played by GLP-1 and GIP, GIT peptide hormons which stimulate secretion of insulin and release themselves into blood when stomach himus penetrates into duodenum, that is before glucose from himus is absorbed into internal body media. Persons with type 2 diabetes have got low level of secreted GLP-1 after meal. Chronic administration of GLP-1 agonists leads to reducing glycemia and HbA1c. The potential of GLP-1 agonists to decelerate progressive decay of beta-cells at diabetics is alluring, but insufficiently documented. DPP-IV inhibitors represent complementary approach for provoking incretin effects, by oral intake of pills.

Regulatory T cells represent unique CD4+CD25+ population of T lymphocytes, which are involved in many immunological events. These cells have very important role in maintaining peripheral tolerance, prevention of autoimmune diseases, in immunological respond to infection, particularly by intracellular microorganisms as well as in a process of tumorogenesiz. There are two populations of regulatory T cells: natural regulatory T cells - nTregs and adaptive, inducible regulatory - iTregs. They differ between each other in accordance to the place of creation, in accordance to the specificity of the T cell receptor, as well as the action mechanism. nTregs and the other T cells arise in thymus, which provides specific inductive environment for maturation and immunological education of progenitor cells to imunocompetent T cells. iTregs arise on periphery from the conventional CD4+ T cells after stimulation by antigen under the different conditions. There is number of subpopulations of iTregs and the most important are Tr1 and Th3 cells. Tr1 cells produce big amounts of interleukin 10 (IL-10), and they are called IL-10-secretory regulatory cells, whereas Th3 cells are necessary for maintenance of peripheral tolerance to mucous surfaces, through their dominant cytokine TGF-â (transforming growth factor-â) and they are most widely spread in the mucosa of the digestive tract. Previous researches have shown that regulatory T cells achieve their suppressor activity via inhibitory cytokines, cytolysis, and induction of metabolic disorders and modulation of maturation or function of dendritic cells.

The objective was to determine the type of venom poisoning causes accidental, sex, age, occupation, place where the poisoning and seasonal distribution. The work was carried out comparative analysis of accidental poisoning in Belgrade in two five-year period 1965th to 1969. and since 2000. by 2004. year. The structure accidental poisoning in the first mentioned period dominated by gas poisoning (CO) and alcohol, and in the second period, poisoning psychoactive substances. In both the five-year period were more likely to be poisoned males. In the first study period, were often poisoned persons older age groups, while in the second period there was a shift to younger age groups. Between 1965 and 1969 and were significantly more frequent poisoning among farmers compared to the period 2000-2004, when they are significantly more common poisoning in students and the unemployed. The highest percentage of poisoned in both investigated period, was found in our own home with no signs of life. Accidental poisoning occurred more frequently in the winter months in the first study period, while in the second period seasonality is not expressed.

Renal osteodystrophy is significant medical, economic and social problem. Over 90% of patients receiving chronic dialysis are facing some type of renal osteodystrophy. The objective of the study is to determine correlation between clinical and radiological findings in patients with renal osteodystrophy. Clinical study was performed in 60 adult patients, different sex and ages, receiving chronic dialysis, with developed renal osteodystrophy. All patients were having following symptoms: bone pain, muscle and joint pain. Muscle spasm were registered in 68.3% of patients, while proximal myopathy symptoms were registered in 86.6%.Dominant radiological findings were: subperiosteal resorption in 53.3% of patients, diffuse osteoporosis in 48.3%, rugger jersey in 33.3% and soft tissue calcification in 18.3%. We have registered statistically significant correlation of clinical and radiological findings. With this study we have confirmed that different types of renal osteodystrophy can be determined by comparing radiological, clinical and biochemical findings, especially in cases when bone biopsy cannot be performed.

Materials wich use like base,and those used for direct and indirect capping should be, except certain physicalchemical and biological performance have and antibacterial effect, to act after the application on residual microorganisms. The aim of this study is that in vitro display antimicrobial activity of some selected resources that are used to protect the dentin below the permanent restoration, and some of this as medication in treating deep surface carious lesions and to directly cover any caries, either artificially open pulp. Antimicrobial activity was tested against microorganisms. On agar plates into the grooves 4 mm in diameter was inserted freshly prepared paste or base. After inserting the material into the surface of bloî od agar, was performed by incubation under aerobic conditions for 24 h in a thermostat at 37 C. Negative effect on the microorganisms, tested materials, it was estimated by the size of growth inhibition zone.

Cancer diseases of female genital system emerge as a result of continues influence of risk factors and heritage base. Commonly accepted risk factors are viruses, sexual intercourses without protection, early sexual relations- where the contact in the period under age 18 is highly risk, smoking (consumption of tobacco) and promiscuities males. Beside mentioned risk factors, we are exploring whether the life conditions and chronically stress are specific risk factors for isolated community. Serbian community in area of central Kosovo counts around 10.000 women in reproductive and menopausal stage. In the period of last 10 years, this specific community was exposed to the aftermaths of Nato aggression in 1999, meaning bombardment with uranium ammunition, poor conditions, refugee exile and return, chronically stress, period without adequate health protection and permanent feeling of life in hostile environment. The results were catastrophic : 5 invasive carcinomas of cervix in female in postmenopausal (56, 71, 50, 76, 54, years of age), 1 squamocellulare carcinoma of vagina (76 years of age) and one squamocellulare carcinoma of vulvae (57 years of age), both in postmenopausal period. In reproductive stage in 3 female H SIL was diagnosed (36, 42, 31 years of age). In three cases, as result of explorative curettage adeno cancer of endometrium was diagnosed (72, 66, 64 years of age).

Basic features of spiral scanners are described, and constructive features of multislace devices are described in detail.Basic principles of functioning and detector number of multislace scanners are described, particularly in 64 layered devices.A short survey of device construction and received X-ray dose during examination is presented. Diagnostic possibilities and multislace scanner application according to organs and organ systems, as well as their advantages in relation to sequential and spiral scanners, are presented.