It is well known that intensive physical activity increase the production of reactive species of O and N (RONS), but 2 it is also known that moderate and regular physical activity has influence on antioxidative system adaptation and help in repairing process of oxidative damage. In this paper we estimated markers of lipid peroxidation (MDA, % ind MDA), and antioxidant status (Asc, DHA/A, GSH, CAT, Pex) for 30 students (control group), and 30 professional football players (regular intensive physical activity). In the group of professional sportsman there were significant increase of lipid peroxidation markers (MDA ↑, % ind MDA ↑), which was also followed by an increased antioxidant activity (Asc ↑, DHA/A ↑, GSH ↑, Pex ↑, CAT ≈). We can conclude that chronic physical activity significantly improves antioxidant status using the adaptation process.

Oxidative stress and associated oxidative damage are mediators of vascular injury and inflammation in many cardiovascular diseases, including hypertension, atherosclerosis, ischemic heart disease, diabetes. Xanthine oxidoreductase is one of the enzymes producing free radicals in the cardiovascular system, and it can contribute to the increment of the oxidative stress and, consequently, blood pressure. The xanthine oxidase is a molybdoenzyme capable of catalyzing the oxidation of hypoxanthine and xanthine in the process of purine metabolism. Xanthine oxidase can exist in two interconvertible forms, either as xanthine dehydrogenase or xanthine oxidase. The aim of the paper was investigate the activity xanthine oxidoreductase in the plasma patients with age related cataract, with hypertensive, and with heart failure. Clinical and biochemical researches were carried out in 73 patients with age related cataract, mean age 72±7 years, divided into group with hypertensive (N=35), with heart failure (N=22) and group normotensive and without heart failure (N=16). Plasma xanthine oxidoreductase activity was determined spectrophotometrically by measuring the formation of uric acid from hypoxanthine at 293 nm. The concentration of triglycerides (TG), total cholesterol (TC), LDL-C, HDL-C in plasma were determined. Our findings show a significantly increased activity xanthine oxidoreductase in plasma hypertensive patients (XO 9.18±1.5 U/L) (p< 0.001) and patients with heart failure (XO 10.44±1.53U/L) (p< 0.001), compared with values plasma xanthine oxidoreductase activity in normotensive and patients without heart failure (XOD 6.02±1.4 U/L). Concentrations of plasma TG, TC and LDL-C were elevated in groups with hypertensive and with heart failure, and we to find significant differences with group normotensive and without heart failure values. Elevated activity of plasma xanthine oxidoreductase contribute to the increasåd oxidative stress and may play a role in accelerated atherosclerosis. 

The authors analysed the importance and results of tympanometric examination by children in preschool institutions of Kosovska Mitrovica, Zvecan, Zerovnica, Socanica, Leposavic, Lesak and Zubin Potok. Children underwent ENT examination, which included clinical ENT examination and accessory diagnostics methods: tympanometric exami-nation and bacteriological analyses of the nose and throat secret. Totally, it have examined 870 children. The most frequent cause of the middle ear impairment was Eustachian tube dysfunction or "willingness of the middle ear for disease" (50,5% cases). Rarely, it was transient effusion in the middle ear and serous otitis media (19,02%). The authors underline a great importance of tympanometric examination by preschool children in detection of middle ear diseases. 

The discovery of Helicobacter pylori (Hp) and the causal relationship between Helicobacter pylori infection with chronic gastritis, gastric and duodenal ulcers and gastric cancer is an epochal event in recent times. The aim of this study was to examine the prevalence of Hp infection and prove the connection between Helicobacter pylori infection and gastric and duodenal diseases in different age and gender categories. Study included 250 subjects of both sexes, different age groups selected random sample. All respondents were subjected to Hp urease test from biopsy specimens of the antrum and corpus of the stomach obtained by upper gastrointestinal endoscopy with standard forceps. The data were analyzed using descriptive statistical methods (CF, SD, Min, Max) and analytical statistical methods. (t test, Chi square test, Kruskal-Wallis test, MannWhitney U test, Wilcoxon test, analysis of variance, ANOVA, Spearman correlation and Persona). Non ulcer gastropathy was the dominant finding that the Hp urease negative (92.2%) and the Hp urease positive (77%)respondents .Duodenalni ulcer was common in the male sex (24.6%) and gastric cancer (2.9%), and stomach ulcer was common in women (4.5%). The most common representation non ulcer gastropathy in the fifth and sixth decades of life while duodenal ulcer was most common in the fifth decade (37.5%). Gastric ulcer was noted in the second, third and fourth decade of life. Gastric cancer is 100% of cases was recorded in the sixth decade of life. Hp Urease test that requires upper digestive endoscopy and biopsy specimens of gastric mucosa is the minimum invasive diagnosis of Helicobacter pylori infection. Upper gastrointestinal endoscopy and HP verification changes the standard in the diagnosis of associated diseases of the stomach and duodenum. (non ulcer gastropathy, gastric and duodenal ulcers and gastric cancer).

Combustion are hypothermic injuries that can occur due to the contact with electricity, chemicals, dry heat, hot liquid and gas, and radiation. In this work there is a 52 year old patient that was treated from combustion on her both feet and her lower legs. Previously, she was treated as an outpatient in a period of 30 days. For the first time in our department we used hydrofiber bandage with Aquacel Ag silver in treating combustion on patient's diabetic foot. These bandages are impregnated with silver that has antimicrobial effect on a huge variety of bacteria. It soaks in a big amount of liquid and bacteria and it helps in removing necrotic tissue from the wound making autolysis debridement. The patient was treated for 35 days on general surgery department. She was released from the hospital in good general condition and with neat local finding. 

Hydropneumothorax is a patological condition of pleura characterised by presence of both liquid and air, rarely of gas between two pleura laminae.According to the origin,it can be result of a disease or a trauma. A typical roentgenogram is obtained during radiography in a standing position and PA projection: horizontal level of liquid represented by homogeneous shadow merging with diaphragm shadow and avascular light without visible parenchyma above the liquid level. The authors present two cases of hydropneumothorax. The first case is about hydropneumothorax originated after several repeated tapping of pleural effusion of malignant etiology. In the second case, hydropneumothorax is a thorax injury complication. Hydropneumothorax rarely appears in practice, and diagnosis is fast and accurate just based on clinical picture and standard lung radiography.

Ankylosing spondylitis is a chronic rheumatoid inflammation with characteristic synovitis of sacroiliac joints and vertebrae of spinal column and fewer coxofemoral and glenohumeral and periferal joints. The disease is of an unknown etiology and shows strong correlation with histocompatibile antigene HLA-B27 wich is found in 90% AS diseased patients. Acute anterior uveitis is the most frequent extra-articular manifestation, it can precede spondylitis and is found in at least 20% AS diseased patients. Acute anterior uveitis is mostly bilateral, with recidives and in inadequate treatments results in complicate cataract and secondary glaucoma. Out of 41 patients with ankylosing spondylitis 36 (87.8%) is of male , and 5 (12.1%) female sex (ratio 9:1). The youngest patient was 25 and the oldest 69 years of age, average age of the diseased was 38.45. Acute anterior uvetis is found in 11, that is 26.8% diseased patients. The length of uveitis is approximately 28+/- 10 days. In 7 patients (63.64%) AAU is found in both eyes. Out of 11 patients with with AAU, 3 patients (27.27%) had more than first attack,7 (63.64%) had 1-5 recidives, and only 1 patient had more than 5 recidives. The most frequent type of exudation is serofibrose (77.78%), then follows fibropurulent-hypopyon (16.67%) and serose (5.55%). Out of 18 eyes, in 14 (77.78%) back synechies were formed. However, these synechies are in most cases broken by the use adequate therapy.

Hyperprolactinemia is the most common hypothalamic-pituitary axial disorder which is found in clinical practice. Increased level of prolactin, regardless of the cause, results in disorder of gonadal function and infertility, while normalization of the level of prolactin is associated with establishment of normal gonadal function and fertility. Establishment of the correct diagnosis is a great significance, because it is possible to normalize the level of prolactin and establish normal function of ovaries in more than 90% cases with specific therapy. The objective of the work is to study concentration of prolactin in each phase of menstrual cycle, its impact (influence) on FSH, LH and E2, as well as the influence of hyperprolactinemia on the rhythm of menstrual cycle. The study has encompassed 150 of women in reproductive period, from 18-40 years of age. The control group includes 50 of women, and there are 100 of women with menstrual cycle disorders (oligomenorrhea, polymenorrhea and secondary amenorrhea) which causes hyperprolactinemia. The turnout of hyperprolactinemia in causes the disorders of menstrual cycle (oligomenorrhea, polymenorrhea, amenorrhea) is 83%, on the basis of the results, wich demonstrates a serious problem and justifies a scientific study.

Treatment, rehabilitation and aesthetics should be the main tasks of modern dentistry. Adequate prosthetic therapy and rehabilitation may be conditioned by different factors. The paper describes prosthetic rehabilitation of a patient, 55 years old woman, with abnormalities in the vertical dimension of occlusion and malocclusion of the third class, and all in order to return of aesthetics and the function of stomatognathic system. The patient came to the clinic due to disturbed aesthetics and function, where was achieved the appropriate amount of bite along with satisfactory aesthetics and functional results due to a combination of fixed and partial dentures. Two metal-ceramic bridges consisted of 13 pieces were built in the upper jaw, and 8 teeth mobile partial denture in lower jaw, thus resulting in satisfactory requirements set to re-establish aesthetics and function of stomatognathic system. 

Epstein-Barrov virus (EBV) is a cause of heterophile antibody positive infectious mononucleosis (IM),which is characterized by fever, sore throat, limfadenopatiom and atypical limfocitozom. IM is mainly a self-limited disease. Complications of the central nervous system, hepatitis (which can be fulminant), (splenomegalia, obstruction of the upper respiratory tract with bacterial can sometimes be deadly.