Bone and joints tuberculosis is a secondary infection of locomotor system, caused by a Mycobacterium Tuberculo- sis. Low incidence of tuberculosis has been maintained for a long period of time due to use of efficient chemotherapy. Howe- ver, in recent years increasing number of newly registered cases is seen, due to wide use of immunosuppressive therapy, spread of HIV, aging population. Those factors influence mycobacterium more likely to become drug resistant. The objecti- ve of the study is to review epidemiological, clinical,radiology and laboratory findings of bone and joints tuberculosis in our patients, and treatment efficiency. In 15 years of prospective study, 107 different ages male and female adult patients, were treated. In most cases spinal tuberculosis was registered (24%), then hip tuberculosis (17%), knee tuberculosis (16%) and tu- berculosis of sacroiliac joint (7%). Non operative treatment with antitubercular drugs was performed in all patients, while in 41% we used operative treatment. Early diagnosis of bone and joints tuberculosis, while treated with non operative (anti tu- berculosis drugs) and operative methods are preconditions to achieve high percentages of long term remission.

Aging as continous biological process, affect all organic systems. Aging is believed to affect the structure and function of the enteric nervous system. Prymary aim these studies is to verify changes in number of neurons in myenteric nervous plexus of human stomach within relation to process of aging. In the course of research played is analysis number of neurons in myenteric nervous plexus of anterior wall stomach. Analysis was performed within 30 tissue samples which are classified into three age groups: (from 20 to 44 years, from 45 to 64 years and over 65 to 84 year old). Played is histological processing and stained with HE, Cresyl-violet, AgNO3 and AChE methods. The morphometric measures operated by morphometric multipurpose test system M42. Finding results are statistically processed by Student-t-test and analysis of variance. Discernible is very heavy loss of neurons of myenteric plexus within the oldest group in relation to younger groups. Applied test show are having statistically notable variance between age groups. In percentage, the loss of neurons in the oldest group in relation to others was from 13,81% to 15,44%.

Copper is an essential element, a constituent of all living cells and an integral component of many enzymes. The increase in pollution of the environment, and various metabolic diseases, imbalances biological processes and homeostatic regulated content of bioelements in the body. For the purpose of determining changes in the contents of bioelements with increased intake of copper, the paper followed by interaction before and after ingestion of copper. The results showed that copper in excess causes disruption of physiological interactions of bioelements in tissues and significantly increases the content of iron and magnesium. The nature and relationships of these interactions are important, because in terms of exposure to metals, there are changes in their mutual relations, with some of these antagonistic relationships may be utilized for further study in order to protect them from toxicity.

The two most common types of skin cancer are basal cell and squamous cell carcinoma, well known as nonmelanoma skin cancers. These cancers are the most common malignant tumors in white population and its incidence is increasing
dramatically. Information about the time of occurrence and cancer growth rate is a significant segment in establishing the primary skin cancer diagnosis. The aim of this prospective study is to determine the correlation between the size of basocellular and squamous cell carcinoma, represented through the function of cancer diameter and time period elapsed from their occurrence up to the surgical intervention. Apart from general anamnestic data, it was also insisted on as precise as possible datum referring to the cancer occurrence time. All cancers have been hystopathologically confirmed. Linear regressive analysis was used for establishing the interdependence between the diameters of tumors and their duration. The average growth of basocellular carcinoma in our patients was 4.3 mm on annual basis, i.e. 6.1 mm annually for squamous cell carcinoma. Tumor duration is a significant anamnestic datum for establishing diagnosis which can indicate a biological aggressiveness or skin cancer type. 

Diabetic retinopathy is the microangiopathy which procedures pre capillary arterioles, capillaries and post capillary venules. The length of disease and poor metabolic control, have the biggest impact on development and progression of DR. By the prospective study in Gracanica Health House, for the period time of six months, there were matched 50 patients with DM tip 2.Along of internal review, there were made ophthalmological review, and anthropometric and laboratory researches.

Even 1000 years BC the famous Persian physician Aviccena describet the first time gangrene diabetes mellitus as a complication. Basic pathohistological substrate vascular complication is atherosclerotic plaqueand therefore is an adequate treatment opf patients with vascular disease is conditioned by timely and precise diagnosis.The introduction of ultrasound technology in clinical practice enabled Edler and Hertz when the shou moves infarction 1954th,a then and Yoshida (1956.) and Sotomura (1959.), Frenklin (1961.) who are using ultrasound display of blood flow in the courts of man. The aim of our study was to deterimne the frequency of occurrences of atherosclerotic plaque in the carotid arteries and ultrasound examination of differences in the variability of certain plaques between patients with diabetes mellitus type 2 and healthy subjects. The examination was attended by a total of 82 people divided into two group. In first group they are 51 persons suffering from diabetes mellitus type 2 in to second control, the number of healthy respondents was 31. Among our respondents, a significantly higher incidence and plaque vulnerability was ina group of patients with diabetes mellitus type 2. 

Any kind of ocular lens opacification is well known as cataract. Most cataracts are age-related, so called senile cataract. Cataractogenesis as process involves either pathological and natural aging processes. Chronical oxidative stress is considered as primary factor in age-related cataractogenesis. In this study we measured concentration of lipid hydroperoxides, sulfhydril groups (SH) and entire antioxidative capacity,as well as ocular superoxide dismutase and catalase activity in 11 subjects with diabetes mellitus (DM) type 2 and cataract and in 39 nondiabetic subjects with senile cataract. All patients underwent complete ophthalmological examination before they were surgically treated by phacoemulsifications. 0 During the intervention, aqueous sample in volume 0,2 was aspirated and refrigerated in -20 C and preparated for further biochemical analysis. Parameters of antioxidative power in diabetic subjects with cataract have decreased values (sulfhydril groups and antioxidative potential - FRAP test) in aqueous while one of lipid peroxidation product has increased value (lipid hyperoxide). Aqueous catalase activity in subjects with diabetes and senile cataract is remarkably higher compared with nondiabetic subjects (p<0.0.5). Oxydative stress and antioxidative capacity are well known risk factor in cataractogenesis but in DM 2 patients, oxydative stress is more intensive than in control group.

Dermatoglyphs are epidermal ridges on the volar surfaces of fingers, toes, palms and soles.Their development begins between 6th and 7th gestational week, so that critical stage of ridge differentiation occurs in the first trimester, coinciding with critical phase of embryonal development. The inheritance of epidermal ridge patterns is polygenic, often markedly affected by some environmental factors causing them to be reffered as multifactorial traits. Genetic determination, time of occurrence, stability and high individuality enable dermatoglyphic analysis to give an insight in critical stage of embryogenesis. Unusual dermatoglyphic variables are found to be significant markers in many numerical and structural chromosomal aberrations .Many investigations have proved epidermal ridges configuration analysis as a powerful additional screening method in identification of congenital anomalies, detection and prevention of different genetically caused disturbances.

The objective was to determine the type of venom poisoning causes accidental, sex, age, occupation, place where the poisoning and seasonal distribution. The work was carried out comparative analysis of accidental poisoning in Belgrade in two five-year period 1965th to 1969. and since 2000. by 2004. year. The structure accidental poisoning in the first mentioned period dominated by gas poisoning (CO) and alcohol, and in the second period, poisoning psychoactive substances. In both the five-year period were more likely to be poisoned males. In the first study period, were often poisoned persons older age groups, while in the second period there was a shift to younger age groups. Between 1965 and 1969 and were significantly more frequent poisoning among farmers compared to the period 2000-2004, when they are significantly more common poisoning in students and the unemployed. The highest percentage of poisoned in both investigated period, was found in our own home with no signs of life. Accidental poisoning occurred more frequently in the winter months in the first study period, while in the second period seasonality is not expressed.

Cancer diseases of female genital system emerge as a result of continues influence of risk factors and heritage base. Commonly accepted risk factors are viruses, sexual intercourses without protection, early sexual relations- where the contact in the period under age 18 is highly risk, smoking (consumption of tobacco) and promiscuities males. Beside mentioned risk factors, we are exploring whether the life conditions and chronically stress are specific risk factors for isolated community. Serbian community in area of central Kosovo counts around 10.000 women in reproductive and menopausal stage. In the period of last 10 years, this specific community was exposed to the aftermaths of Nato aggression in 1999, meaning bombardment with uranium ammunition, poor conditions, refugee exile and return, chronically stress, period without adequate health protection and permanent feeling of life in hostile environment. The results were catastrophic : 5 invasive carcinomas of cervix in female in postmenopausal (56, 71, 50, 76, 54, years of age), 1 squamocellulare carcinoma of vagina (76 years of age) and one squamocellulare carcinoma of vulvae (57 years of age), both in postmenopausal period. In reproductive stage in 3 female H SIL was diagnosed (36, 42, 31 years of age). In three cases, as result of explorative curettage adeno cancer of endometrium was diagnosed (72, 66, 64 years of age).