The most important adipocytokines affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. The essence of this test is to determine the correlation of the leading biochemical parameters of atherosclerosis, adiponectin and resistin and determine their interdependence with other biochemical parameters in patients with diabetes mellitus and coronary heart disease. Our study group consisted of 140 patients and 40 control group (healthy), 50 with diabetes mellitus and 50 with coronary heart disease (myocardial infarction and angina pectoris). We find that the average value of adiponectin in the group with type 2 diabetes mellitus were significantly lower than in the control group (4.38 to 6.74, p = 0.001, p <0.05). In the same study group average value of resistin was significantly higher than in the control group (15.8 to 7.88, p <0.001). The average value of adiponectin and resistin in patients with myocardial infarction and angina pectoris are no different from the value obtained in diabetes mellitus (4.94 to 4.38 and p = 0.397, p> 0.05). In the same study group average value of resistin was significantly higher than in the control group (15.73 to 7.88, p = 0.001, p <0.01) and not different than in the group with diabetes mellitus. Values Pearsonovg correlation coefficient shows that the biggest falls inversely proportional dependence of adiponectin with a simultaneous increase in resistin is expressed in patients with myocardial infarction, which is expressed very good correlation coefficient (-0.36). In all the groups, shows that there is a negative correlation between resistin and adiponectin, with increasing values of resistin values of adiponectin are reduced.

Leukoaraiosis is a change in brain white matter with characteristic manifestation in MR and CT head scans. Common leukoaraiosis risk factors include aging and arterial hypertension. A quarter of symptomatic ischemic infarcts belongs to small blood vessel disease group and could be presented as lacunar infarcts. These two crucial pathophysiological mechanisms are in the root of cognitive dysfunction related to small blood vessel disease. 60 lacunar infarct patients were examined and parameters for groups with and without leukoaraiosis were determined. It was found that leukoaraiosis incidence was highest in the group of women older than 70. Neurological assessment was scored on NIH-NINDS scale, functional status was scored with Barthelo index, and cognitive status was determined using Mini Mental State Examination (MMSE) and Alzheimer Disease Assessment Scale Late (ADAS-L). Correlation analysis of these parameters on significance level of *p<0.05, **p<0.01, suggests decrease in neurological status and cognitive performance.

Disturbances of thyroid function are often accompanied by cognitive and affective disorders. Assessment of cognitive status in the patients with subclinical hypothyroidism represents a possibility for early diagnostics of cognitive impairment and timely introduction of necessary pharmacotherapy treatment. The aim of this study was to quantify whether there are P3 event related potential (ERP) deviations as electrophysiological markers of cognitive activity in patients with subclinical hypothyroidism. P300 potentials were examined in thirty patients with subclinical hypothyroidism and in 30 healthy subjects of the control group. P300 was recorded using the classic auditory oddball paradigm, with 20% of target and 80% of non-target stimuli. The results analysis showed a significantly longer latency P300 and reduced amplitude P300 in subjects with subclinical hypothyroidism compared to euthyroid subjects. There is also a statistically significant negative correlation between the results of a mini mental state examination and the P300 latency at Fz electrode (r= -0.47, p <0.01) and Cz electrode (r= -0.43, p =0.017). P300 ERP is important in the evaluation of patients with subclinical hypothyroidism, due to the sensitivity in the detection cognitive disorders.

Cilj rada je da utvrdi patoloske promene na sluznici gastroduodenuma (erozije,ulceracije, ulkusi, komplikacije ulkusa,subepitelna krvarenja i dr) nastale kao posledica stetnog dejstva NSAIL (Nesteroidnih antireumatika )lekova koji su ordinirani u terapiji Reumatoidnog artrit-(RA). Ispitivanje je vrseno na 100 bolesnika sa dijagnostikovanim RA koji su bili na kontinuiranoj terapiji NSAIL. Kod polovine bolesnika uradjena je gastroskopija da bi se verifikovale patoloske makromorfoloske promene pre kontrolisanog uzimanja NSAIL Posle 2godine uzimanja kontinuirane terapije NSAIL uradjena je kontrolna gastroskopija a patoloske makromorfoloske-endoskopske promene verifikovale. Posle dvogodisnje kontrolisane terapije NSAIL na sluznici gastroduodenuma erozije su opisane u 66% bolesnika, ulkus zeluca u 18%, duodenalni ulkus kod 14% bolesnika, krvarenja u 25% bolesnika.

Introduction: Osteoporosis is a disease characterized by bone strength disorder and weakness of the entire skeleton causing the predisposition to fractures to grow. Identification of factors which may influence pathological fractures in postmenopausal women and determining which of the identified factors have the largest influence on the development of osteoporotic fractures. A retrospective study has included 400 postmenopausal women with newly diagnosed osteoporosis examined at the Institute of Rheumatology in Belgrade. We have examined demographic data and the following fracture risk factors: physical activity, menarche, menopause, fractures after the age of forty, osteoporotic fractures in the family, comorbidity: inflammatory rheumatic diseases, intestine diseases, chronic kidney insufficiency and endocrinopathy (hyperthyroidism and diabetes) and taking glucocorticoid therapy. The value of bone density has been measured using DXA method in the spine and hip, and the body mass index has been calculated based on the body height and weight. Logistic regression has been used as the method for analyzing the relation between binary results and potential predictors. Statistical hypotheses have been tested at the statistical significance level of 0.05. In the model of multivariate logistic regression, the significant predictors of osteoporotic fractures are as follows: older age (B = 0.13; p = 0.001), higher BMI values (B = 0.094; p = 0.022) and lower BMD values (hip) (B = -3.060; p = 0.023). Elderly overweight women with lower BMD values in the hip are more susceptible to fractures due to osteoporosis; therefore this subgroup of postmenopausal women is important for the application of the measures of primary and secondary prevention of osteoporotic fractures.

Introduction: Medico-legal expertise and identification of victims during the war and post war conflicts mean for The Republic of Serbia the most important humanitarian, scientific and ethical problem. Aim: Forensic investigations on territory of Kosovo and Metohija are currently going on. Material and methods: In this paper we observe all cases of Serbs and other nonalbanians who were exhumed and identified during first five years after armed conflict (2000-2005.), in few mass graves and in many single grave sites. Results. In the mentioned period of time, 280 dead bodies were exhumed and forensic team did autopsies, 111 dead bodies were identified. Conclusion: Well done forensic expertise is a prerequisite to the successful identification, but also the criminal processing of cases in the category of war crimes, which all together give a distinctive character. The research, published and presented in this paper at the identified human corpses, through the general data, identified violations, determining the cause and manner of death, as well as its origin, with all the available documentation of circumstances that led to the death is also the scientific and historical evidence of the tragic fate of the missing persons and victims.

Senna (Cassia angustifolia Vahl.) is used in food and pharmaceutical technologies as officinal drugs and natural laxative. The aim of the study was to investigate the effect of toluene and methanol Senna extracts on the viability and proliferation of HeLa cells. The senna leaves were extracted in Soxhlet's extractor and obtained toluene and methanolic extracts were used for determination of effects on viability and proliferation. Cytotoxic effect of different concentrations (0.1%, 0.01%, 0.001% and 0.0001%) extracts was investigated in HeLa cells in vitro. MTT test showed significant cytotoxic activity for toluene extract, especially the concentration of 0.1%, while the tested concentrations metanolic extract did not show cytotoxic activity.

Development of accessory breast tissue is a consequence the lack of regression remanths of milk line during embryogenesis. These remanths can be found anywhere on the ventral side of the body, extending from the axilla to the pubic region and most of them can be found in the axillary region. On such a tissue may appear almost identical changes that affect the normal breast, from benign non-tumor changes to malignant tumors. In our case report, the case is a 23 year-old woman who had a unilateral solitary lesions in the axilla, which was surgically removed. Starting diagnosis was " Limphadnopathia axillaris lateris sinistri." After removal and histopathological evaluation of the change, it was found that there is a tumor - fibroadenoma. There were also performed immunohistochemical ( IHH ) staining, with finding of a conventional fibroadenoma of the breast as expected. Accessory breast tissue in the axilla is a rare finding, and the tumors in this tissue even rarer. Histopathological confirmation is mandatory, with the need to exclude malignant tumors which are more common in these cases, and they occur at an earlier age.

We examined the impact of aerobic exercise on morphological characteristics and agility in elementary school children. Anthropometric characteristics of the subjects were as follows: longitudinal skeletal dimension (body height, as well as the lengths of upper and lower extremities), circular skeletal dimension and body mass (mean circumference of the chest, the circumference of the thigh of an stretched leg, maximum circumference of the calf, body mass) and subcutaneous fat (skin thickness of the abdomen, thigh and calf). The agility was estimated by the envelope test, side steps and a eight with bending. For statistical analysis we employed the basic methods of descriptive statistics, while the discriminatory power of measurements was estimated by calculation of skewness and kurtosis of the data. Canonical correlation analysis was applied to explain the structure of the relationships between the two sets of data. The results of the analysis on this sample suggest that there is a strong linear relationship between morphological characteristics and agility at a multivariate level.

Artritis urica (giht) je klinički sindrom čije su glavne karakteristike recidivirajuća upala jednog ili više zglobova zbog hipersaturacije mokraćne kiseline i odlaganja kristala urata u zglobove i okozglobne strukture, stvaranje tofa, deformacije zglobova zbog uratne artropatije i nastanak uratne nefropatije. U zavisnosti od faze bolesti ispoljava se bolovima u zahvaćenim zglobovima, recidivnim artritisom najčešće u bazalnom zglobu palca ili ređe u drugim zglobovima stopala praćen deformacijama. U radu je obrađeno 40 ispitanika i prezentovani su rezultati kliničkih manifestacija bolesti, laboratorijski, radiološki nalaz i prisustvo konkomitantnih bolesti.