The research was conducted at the Department of Pathology and Histology of Clinical center of Novi Sad. We analysed the reports of autopsies of newborns (to 28 days old), stillborns and miscarried fetuses in 1991 and 2001. Found
malformations were classified according to organ systems. Results for 1991 show next structure of congenital malformations: 3 malformations of central nervous system (14.29%), 0 malformations of urogenital system (0%), 3 malformations of
gastrointestinal system (14.29%), 1 malformations of musculosceletal system (4.76%), 9 malformations of cardiovascular
system (42.86%), 1 chromosomal defects (4.76%), 4 multiple malformations (19.05%). Results for 2001 have next value: 9
malformations of central nervous system (27.27%), 4 malformations of urogenital system (12.12%), 5 malformations of
gastrointestinal system (15.15%), 0 malformations of musculosceletal system (0%), 4 malformations of cardiovascular
system (12.12%), 2 chromosomal defects (6.06%), 9 multiple malformations (27.27%). By the comperison of the results of
structure of congenital malformations in 1991 and 2001, we can conclude that the differences of cardiovascular and urogenital malformations are statistically important

In this research it was examined how fatigue in the working process affected the speed of reaction on a complicated
stimulus, and also on the frequency of inadequate reactions. The investigation was carried out by means method of combine
reaction time (CRT). CRT is the shortest time that passes from the moment when a person is affected by a complicated stimulus until the moment when the person responds to the stimulus, by making adequate and complicated reaction. CRTwas registrated in working population of railroad employees who were divided in two groups:group of locomotive drivers (n= 44) and group of a railroad employees (n=25). In the group of locomotive drivers it was taken into the consideration whether the type of locomotive was electrical or diesel power. In both groups, CRT was registrated in two phases of working process; before and after daily work. Results showed that in both examined groups CRT got significantly extended after the
working process. Duration of CRT was longer before and after working process in the group of electrical power locomotive
drivers compared to diesel power locomotive drivers. Fatigue did not affect significantly on the frequency of incorrect answers

Menopause may influence negatively the cardiovascular system of women, especially that of smokers. The aim of
our study was to compare lipid levels and left ventricular function in postmenopausal women smokers and non-smokers
during 12 months of oral estrogen replacement therapy. The study group included healthy postmenopausal women, 30
smokers and 32 non-smokers. Before and in 6 month intervals the following parameters were followed: total cholesterol,
LDL-, HDL-cholesterol, triglycerides, blood pressure and echocardiographic parameters of systolic and diastolic left
ventricular function. Before therapy non-smokers had higher total and LDL-cholesterol, when compared to smokers. Oral
estrogen replacement therapy significantly decreased levels of total and LDL-cholesterol and increased HDL-cholesterol,
only in non-smokers. No change in lipid levels was observed in smokers. However, women who smoked longer had higher
triglyceride levels after 12 months of oral estrogen replacement therapy. Echocardiography revealed significant improvement of systolic and diastolic left ventricular function in non-smokers, while improvement of only systolic function in
smokers. Our study has shown that 12 months of oral estrogen replacement therapy may not have a protective role on the
cardiovascular system of postmenopausal women smokers

The frequent sign in renal disease and disease of urinary tract is presents of blood in urine, hematuria, and it is discovered very often in children. Aim of this work was to establish the most frequent causes of hematuria in our recorded
material. Investigation was accomplished on 60 patients, by using standard clinical and biochemical methods. The results of
work have showed that hematiria may be faund in any age in children. Most patients belong to age 5-10 years 27 (45.0%),
belong to age up to 10 years, and 26,6% belong to age 1 -5 year. Hematuria is more common in school-aged children and in
adolescence. Gross hematuria is found in 60% of patients, and microscopic hematuria in 40% of patients. Infective cause of
hematuria is found in 29 patients, and in 31 patients other causes, such as : stones, sec.glomerular diseases, tumors, hematologic disorders, etc. As infective glomerular disease and infection of urinary tract, in 25 % patients the cause of hematuria is acute poststreptococcal glomerulonephritis, tuberculosis in 6,66 patients,urinary tract infecion in 16,6 patients (in 8,33% patients caused by E.colli). Anatomic abnormalities is found in 15% patients,asymptomatic hematuria in 6,6%, lithiasis in 5%, and Henoch - Schönlein in 5%, and coagulopathies in5 % of patients, other causes are rare.In observed sample of patients, we have registrated high frequency of hematuria in chlidren with ac. poststreptoccal glomerulonephritis, then in children with morphological abnormalitis of urinary tract,urinary tract infection, and IgAnephropathia as a very rare cause, but Trachtman and Hagg in their reserches found Alport syndrom and IgA nephropathy as a most frequently causes of Hematuria

Powers was the first scientis who described Varices oesophagei in 1939 (Thomas in 1960) in the 19th century,
th Varices weve considered like consequence of splenies sicknes, was noted like 20 century, portal hypertension, noted like
pathogenesiscal machinery for begining. Varices oesophegei and classification. Oesophagoscopy was vade by 40 patients
because varices were veryfied and a factor of risk, which varices have was measured. Endoscopy morphologycal classification Varices oesophagei was used by Paque in 4 class. Varices in the first class was had 17,5% in the second class 35%, in the second and third class 22,5%, the fourth class 5%. Varices in the third and fourth class have observed like bigs Varices who have very risc and ruinouses for life.

On the territory of Yugoslavia Q fever presents a significant health and epidemiological problem. In Vojvodina Q
fever is being reported in epidemic form. In adition to, sporadic cases are registrated in Central Serbia as well. In Kosovo and Metohia during this period there was no single case of Q fever diagnosed. This disease is primary professional illness. Q
fever is more often diagnosed in male compared to female gender. Among reported cases elderly structures between 20 and
59 dominate and participation of those elderly groups estimate 78,4% of all registerd cases. Q fever has a strictly seasonal
character, and the most cases are reported in the period January-April

Hypoxic-ischemic encephalopathy (HIE) and intracranial haemorrhage (ICH) are the most common neurological
diseases in newborn period. Very often they are caused by perinatal asphyxia and they may lead to permanent disturbances in psychomotor development of infants. The aim of this study was to evaluate the significance of neurological examination and other diagnostic methods in both diagnosis and prognosis of HIE and ICH in high - risk newborn infants. We prospectively examined the group of 115 infants who were followed till the age of three years in order to evaluate their neurological development. Neurological status during newborn period and the first year of life were abnormal in 62% of infants, ultrasound examination of the brain results were abnormal in 60% of infants and electroencephalographic records were abnormal in 23% of infants. Magnetic resonance imaging were done in 25 infants, showing patological changes
predominantly localized in periventricular white mater, basal ganglia and talamus in 10 of them. At the age of three years, we
found that seven infants had moderately severe neurological deficits and nine infants had severe neurological deficits. We
concluded that neurological examination and ultrasound examination of the brain were of limited diagnostic and prognostic
value while electroencephalographic examination was of great significance in infants with neurological disturbances.
Magnetic resonance imaging of the brain was very good method in evaluating pathological changes in the brain of studied
infants, and the spectrum of pathological changes correlated very well with the type of neurological deficits. Prognosis of
neurological development of infants with pathological changes predominantly localized in the region of periventricular
white mater were better than of infants with pathological changes in the region of basal ganglia and talamus who had very
bad prognosis.

Beside great improvement in diagnostical ant therapeutic aproach in curement of brain tumors, gliomas still have
bad prognosis. Better results could be obtained only in early tumor discavery. Alpha pheto protein (AFP) and carcinoembrionic antigen (CEA) are markers specific for certain carcinomas (hepatocelular, nonseminated testicular, colorectal). Thieir specifity for gliomas still has not been stated. The aim of tis study was to determine tissue or sera levels of AFP, and CEAin experimentaly induced gliomas, and teir poential use in human gliomas diagnosis. For analyses , tissue supernatant homogenate C6 of rat glioma and sera were used during different phases of development (days 0,7,14,21 and 31). Tumor markers were also determened as well as in tissue of human brain tumors (two anaplastic astrocitomas an one glioblastoma). Techique applied was immunoenzyme type Mein method. Obtained results showed no signs of AFPeither in sera, or in rat brain tissue or human glioma tissue. CEA however, showed statisticlly, important specifity, for glioma tissue. During tumorgenesis tissue concentracion of CEA showed statisticly higher levels in comparasion with controls , starting from day 7, reachin peak of tumorgenesis on day 21, (p < 0.001). CEAwas not detectable in control animal group sera, and also during the period of tumor development. CEA concentracion obtained from animal brain were similar to those in human
brain tissue tumors. Further investigation need to be caried out, in order to determine the potential role of this marker in
diagnosis and treatment establishment course.

With this work we intended to examine antipyretical effect of different extracts from the leaf. The following extracts were examined: etherical chloroformic The experiments were conducted on white laboratory mice, type BALB/C. Mice were divided in 5 groups, where each group received the appropriate extract. Rectal temperature was measured by "Termistorowy" termometer. After the temperatures were measured, for each of examined group we defined area under the curve. The area values were later used to determine statistically significant differences between them. Examination results of antipyretic effects of different extracts ( ) from the leaf, i parsley (Et O), (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquae- 2 3 ous (H O). 2 etherical (Et O), chloroformic (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquaeous (H O) parsley 2 3 2 n experiment with mice, show that all the extracts mentioned above, decreased (annuled) pyrogenic effect of 12% yeast suspension. 

The aim of our work was to inquire after frequency and characteristics of repeated myocardial infarction. We questioned prospectively 123 patients, diagnosed with acute myocardial infarction, who were hospitalized in the Coronary unit
of Krusevac Health centre, during the period of 01. 02.- 31. 07. 2001. Repeated myocardial infarction was found in 16,26%
of questioned patients. Non Q acute myocardial infarction was found in 35,00% on patients with repeated myocardial infarction and 8,74% on patients with the first myocardial infarction (p<0,01). In patients with repeated myocardial infarction
more often was found heart failure (55,00% vs 20,39%, p<0,01). Repeated myocardial infarction have difficulty clinical
flow, but have not statistical significantly higher early mortality