Specific immunotherapy (SIT) has been used for almost a century but its form of administration is still a matter of
debate. At present curative SIThas only demonstrated its efficiancy, under the conditions that an appropriate allergen extract
is used, and patients are careffuly selected. However, many alergic patients likely to respond to immunotherapy are not
treated specificaly, due to the prevaling opinion that immunotherapy is ineffective, and has more uneffectable side effects
than drug treatment. Direct comparison of efficiancy between immunotherapy and drugs is problematic as this implies a
comparison between a treatment aiming at interfering with the pathophysiological mechanisms of the alergic inflammation
with potential for long term effect, or even cure (immunotherapy), and a treatment abolishing symptoms whi-le being
administered, but without long term preventive capacity (drugs). In most patients the situation is not an either but ra-ther
both and. The advantages of combinig immunotherapy and drugs are related to a higher likelihood of increasing effi-ciancy,
reducing side effects, and improving patient compliance by combining a treatment having an immediate effect with one
functioning more slowly

The level of the health protection determines the living standard of people in that area. If the standard is higher the health protection is on a higher level. Extraordinary circumstances on the territory of Kosova and Metohia in the period of th almost whole last decade of 20 century caused much lower of health protection. It happened a spontaneous mobilisation of all factors of normal life in this area, causing an improvement in this matter. First public health workers made some changes and permitted their work with a great enthusiasm. Social-political structure of this area connected humanitarian organizations while Serbian population showed a strong determination to struggle with is strength for the existence in this area. Therefore the lowest level of the health protection in 1999 started gradually to improve. By opening new section within the Health Center in Zubin Potok (orthopedic and neurological) the scope of the health protection of the people got more extended. Orthopedic section opened an X-ray room where we X-rayed injures and sickness of the locomotor systems. In the period 1999-2002. we checked 8692 sick people (42,65% workers, 49,30% housewives and pensioners and 8.30% children). However, we did 1404 surgery operation. We took out 82 benign tumors, 64 objects and 59 skin excision (removal of para-site-ixodes ricini). Nevertheless, we put 2039 bandages where injures and sickness of locomotor systems occurred. During the last 3.5 years we did 301 X-ray photos. Gradual improvement of the standard of people, improvement of the social-political situation and further strong motivation of the population to stay in this area, contributing to better medical treatment and healing of sick people. It is contributing to the existence of the Serbian population in this area.

Planning daily activities, depending on neurophysiological chronotipology, is one of the steps, which should be taken towards the more successful, healthier, high quality life. Aperiod of time within a day during which the individuals of both sexes, different age and profession are intellectually the most optimally efficient, was determined in the paper. The chronotype of a given person was taken into account for that purpose. The research was carried out using a questionnaire. The questioned individuals were divided into four groups: 120 students at the University of Novi Sad, 50 professors at the University of Novi Sad, 50 railway workers and 50 female civil servants employed in administration. The obtained results show the following: the highest percentages of students belong to the morning chronotype. They sleep more than professors do and the optimal time convenient for mental and heavy physical work is from 11 AM to 1 PM. This data should be taken into account while planning student tests. The University professors, both male and female, belong to the morning chronotype. The female professors sleep more than male professors, but are psychologically and physically optimally productive at the same time as the male professors, from 8 AM till 10 AM. In the group of railway workers, the most common are individuals of indifferent chronotype. The highest percentage of women employed in administration belong to the morning chronotype and for their optimal psychological activity they choose the period of time between 8 and 10 AM, as well as the railway workers. According to the opinion of most people that have been questioned, among all of the abovementioned groups, the optimal five-hour working period should begin at 8.30 AM.

Hiposmia or anosmia are common cases after infections. The virus of influenza is most common cause of anosmia
and hiposmia. In a cause of hiposmia and anosmia which are the results of influenza it is need to start with regular and actual theraphy, or in other case anosmia or hiposmia are permanent.

Aim of this work was to ascertain kind and frequency of skin sensibility to inhalation allergens and determine importance of skin allergic "prick" test. Investigation was accomplished on 141 patients by skin allergic test in vivo with standard "prick" technique. The results of work have showed that allergy is unquestionably present in the rhinosinusal diseases, as well as certain relationship between these diseases and allergic skin "prick" test, but this relationship was insufficient to determine skin allergic "prick" test as enough sensitive and specific diagnostic method for diagnose allergic rhinosinusal diseases. "Positive" allergic skin "prick" test demonstrate patient's hypersensitive reponse on inhalation allergens and existence of allergy, but not the direct connection between this hypersensitive reaction and rhinosinusal diseases. "Negative" allergic skin "prick" test not exclude existence of allergy, and for that, patients which have suspect allergy at the aim of further investigation must be apply other more sensitive and specific diagnostic method.

Reduced glutathion (GSH), glutathion-reductase (GR) and glutathion-peroxidase (GSH-Px) are significant indicators of oxidative stress. Oxidative stress is a consequence of increased production of reactive oxygen radicals and/or on the other hand, insufficient antioxidative protection. It is well-known that free radicals have key role in the large number of biological phenomena, such as differentiation, transformation, signal transduction, aging etc., and they are important factors in pathogenesis of various diseases (carcinoma, diabetes, Alzheimer, Parkinson, aterosclerosis). This paper presents results of investigation of content of GSH and activities of GR and GSH-Px in healthy patients and diabetes insulindependent patients between 20 and 75 years of age in the region of Indjija. Correlation between investigated parameters in healthy persons and diabetics was found, as well as with results of similar investigations in other countries. Investigated sample comprised 200 healthy patients (20-75 years) divided into 5 groups, and 80 diabetes patients divided into 4 groups. Every group consisted of equal number of males and females. Above mentioned parameters were determined in hemolysate. Parameters change depending on patient age, and changes are more intense in all patients. Some differences exist in correlation of our results with results obtained in other regions.

Measles are an acute infective disease highly contagious and belongs to the group of rush fevers. The aim of this paper is to examine the epidemiological characteristics of measles in Kosovo and Metohija after introducing the vaccine. The examination was carried out from 1987-1998. Because of the bad success after introducing the vaccine against measles in Kosovo and Metohija, which was not reached the issued minimum of 95% in either year, the measles have kept their epidemiological characteristics that they had in the prevaccinal period. The morbidity rate was in 1989. the highest (215.99 on 100000), and the lowest in 1995 (2.29 on 100000). Mortality rate was between 0-0.66 on 100000. It is very important that in those 4 years there were no dead cases. The cycles are still being registered by measles, with epidemic waves of 3-4 years. Seasons are also preserved, and the top of it is the month of January (291.3 patients on the average). Most patients belong to the preschool age (80.0%). Male children got more often ill (55.1%) than the female children.

Although the assessment of quality of life in past 30 years became more important in the praxis of health care, measuring of quality of life is still relatively new and poorly investigated concept. Quality of life refers to the physical, physiological and social domains of health, seen as distinct areas that are influenced by a persons experiences, belifs, expectations and perceptions. Today it is a very important issue in health care practice as well as in scientific research. In our country there were no trials of measuring of quality of life, so this study could be considered as a first of that kind. Aim of this study was to show components of health and quality of life among school children and youth as well as differences considering their age. Culturally adapted version of Child Health Questionnaire (CHQ) was used as an assessment o instrument. The study was performed on a random sample of children and there parents (N =600). This paper describes the study results from parent version of questionnaire. At almost all single scales of health and quality of life, as well as on aggregate scales of physical and psychosocial well-being, most adverse values were obtained for elderly children. Significant differences were found on scales of physical health, accomplishment of social role (considering emotional state and behavior), bodily pain, mental health, self-esteem, family activities and family cohesion, as well as on a aggregate scale of physical well-being. This results confirmed an influence of age on quality of life among children.

Pseudoexfoliation syndrome (PEX Sy) presents a continual challenge to the ophthalmologists because of its unknown etiopathogenesis and development of aggressive glaucoma and some complications of the cataract surgery. Contemporary hypothesis focus oxidative stress as a clue event in the ageing process, as well as in age-related cataract genesis. Frequencies of the secondary ageing diseases were investigated in 162 patients with age-related cataract and 55 age and sex matched control subjects, and some elements of the oxidative stress-antioxidation protection and the lipid peroxidation products in their serums. Similar parameters of oxidative stress were also analyzed in 80 samples of humour aqueous and corticonuclear lens' blocks, and compared according to the different secondary ageing diseases appurtenance (diabetes mellitus, atherosclerosis, obstructive pulmonary diseases etc.), also including PEX Sy. Examined influence of secondary ageing factors and PEX Sy on the age-related cataractogenesis by logistic regression showed the highest odds ratio for the PEX Sy(OR=4,516; p<0,05). Among investigated antioxidant elements (vitamins C and E, peroxidasis, GSH, catalase, albumin, %iMDA) in serums, catalytic activity of catalase shows significantly lower values in patients with PEX Sy(p<0,05). Antioxidant defense of humour aqueous, expressed as rate of induced malondialdehyde (%iMDA), and total sulfhydryle groups in the lens' corticonuclear blocks (TSH) have a lower values, whereas contents of lipid peroxides (LP) shows to a higher degree of the peroxidation in patients with PEX Sy, similar to the findings in patients with cataract and other diseases of the secondary senium. Changes on the corneal endothelium, in the anterior chamber angle, iris and lens, at the presence of the PEX Sy, in some extent respond to the hasten ageing. Findings considering the antioxidative defense and lipid peroxidation, point to possibility that, at least part of pathogenesis of ocular alterations with PEX Sy, appears due to higher oxidative stress. Lower activity of catalase may suggest to the liver function examinations, with the aim of investigation of the PEX Sy nature.

The aim of the work is to study the development of twin pregnancy after one of twins died in early pregnancy and
possible negative influence on clotting system of pregnant women. Observation is done on patient DM, 30 years old, and
housewife. She was observed from her first appearance at the department. Personal and family anamnesis was regular. She
had one delivery tree years ago with Cesarean section. In the first ultrasonographic examination we found twin pregnancy
with obvious heartbeats of both twins. After two weeks on control examination we find only one fetus, regularly developed,
and in a separate amniotic cavity a fetus without heart beat with small quantity of amniotic fluid in bizarre position. Patient
was immediately admitted in the hospital. Ultrasonographic examination, as well as a routine laboratory analyses were
repeated every ten days. After 28-th week of gestation we included a cardiotocographic (CTG) control every five days. In
38-th week the birth was finished by cesarean section (indication for operation - previous cesarean section). Afemale child
was born. After delivery, placenta was extracted with membranes, which contained a dead fetus, 12-cm length. After
recovery which lasted seven days patient was dismissed in good condition with healthy baby. An ultrasound examination
proved to be of great help in putting a diagnosis. It is very important to put diagnosis in time, because if we don't do it, we
will probably have a great and heavy complication.