Natural system of disease genesis is a complex occurrence. «Net» review of cause can be based on systematic approach and it doesn't have to, and so those are homonyms. Complex occurrence of the genesis of a disease is given as a arranged set by relation «predecessor-follower». Chain reaction is that one which has hierarchic arrangement because of managing. By systematic approach the causality is being created.

Change in left ventricular volumes, particularly end-systolic volume index is a major representative of left ventri cular dilatation, and is a predictor of mortality after acute myocardial infarction of anterior localization. Several large-scale trials have demonstrated beneficial effectiveness of ACE inhibitors on the process of left ventricular remodeling after myo cardial infarction, not only in patients with compromised systolic function. Aim of the study was to evaluate the influence of therapy for ACE inhibitors in the early faze of anterior myocardial infarction, trough dynamics of left ventricular volume in dexes. During six months 30 patients were evaluated with echocardiography in admission, before leaving the hospital, after
three and six months after myocardial infarction. In evaluated group there was increased end-diastolic and end-systolic vo lume index, but without statistically significant value. There were no new cardiac decompensations. We concluded that ACE inhibitors given in the early stage of acute myocardial infarction anterior localization have beneficial effect on the process of left ventricular remodeling and that is recommended to bee given to this patients, after excluded contraindications

Biliary calculosis is the most frequent disease of the hepathrombial system. Inflammation of the gall bladder appears in the acute and chronicle form. Acute inflammation presents one of the frequent complications of the gall bladder
calculosis. Acute inflammation of the gall bladder can appear in catarrhal, phlegmonous, gangrenous perforative form. Perforation of the inflamed changed gall bladder can lead to the diffuse biliary peritonitis, pericholecystitis and formation of
pericholecystitis infiltrate or abcess. Very often the acute inflammation of the gall bladder appears in combination with Acute inflammation of the pancreas. For the production of the work the biyearly material of the Emergency Surgical Centre
“Simonida” in Gračanica is used. In the ESC Simonida, in the period from January to December of 2004, 375 patients were operated. In the same period of time we operated 52 (13.86%) patients because of the gall bladder disease and biliary ways.
There were 45 female patients and 7 male ones. Gall bladder disease is 6.5 times more frequent at females in our material. Hard security situation and limited freedom of movement are one of the most important reasons of patients' late report to the
doctor, and appearance of the heavy forms of the inflammation of the gall bladder and biliary ways. The acute form of the inflammation of the gall bladder was noticed at 25 patients. The complications of the disease in the sense of cholecystopancreatitis, choledolithiasis, suppurating cholangiitis, choledolithiasis i cholecystoduodenal fistule were found at 27 patients. Postoperative complications were verified at 3 patients, wound infection at 2 patients and peritonitis at one
patient after drawing ouf the T-drain.

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the
dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. According to the obteined data, medicaments
used in treatment of gastroinestinal tract contributed with 15.52 DDD/1000 inhabitants per day. Most commonly used are antacids and anti-ulcer drugs (8.14 DDD/1000 inhabitants per day). Medicaments used in treatment of muscular and skeletal
system contributed with 14.30 DDD/1000 inhabitants per day. Antiinflammatory and antirheumatic drugs sre used in amounts of 14.18 DDD/1000 inhabitants per day. In our country there is no complex survey of drug usage because there is no way of monitor ing which could apprehend all possible information sources. Defined daily dose is not introduced into practical qualitative and quantitative monitoring. It is necessary to make systematic network of information sources to provide for insight into medicament usage

The retrospective study included all patients treated at Clinical Centre in Kragujevac, who needed an acute HD treatment due to vital endangerment, during 2003. The objective of this study was to demonstrate our experiences in treating these patients using central venous catheter. The results of this study show that femoral catheters are dominant (over 95%), with slight using of jugular and subclavial catheters (5%), in spite of the recommendation of the American Association for Renal Diseases to use femoral catheters only for patients supposed to be in hospital during the interval of 5 days. The
frequency of infections in our study (16,6%), coincides with the data of the American Association for Nosocomial Infections (NNIS)[1] (17,8% catheter infections). Gram-positive bacterium from Staphylococci group are the most frequent cause of catheter infections also in our patients

The urgent surgical intervention need great atention in pregnant patients because of vital indication all surgical procedure interffer with pregnancy togheter with general anaesthesia and could cause complication of pregnancy and some times a damage of the foetus. Our study include all surgical procedure as the acute abdomen, trauma and politrauma in pregnant patient. Our aime was to give general anaesthesia which should be safe for mother and foetus.Post-operaative therapy and treatment of patients was done by theam of anaesthesia and gynecologists. The anaesthesia monitoring and surgical procedure have been improved up to the presset day but there are steel present great ricks in a treatment of this type of patients.The criteri in surgical and conservative treatment of pregnant patients was determined in colsultacion anaestetist-gynecologists.

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. Antiinfective medicaments in systematic use, according to the obtained data, participate with only 7.96 DDD/1000 inhabitants. The most applied pharmacotherapeutic subgroup with 2.99 DDD/1000 inhabitants is comprised of cephalexine and cephachlor. 

Chronic pulmonary heart (CPH) stands for presence of hypertrophy and/or dilatation of right heart ventricle caused by pulmonary hypertension as a consequence of diseases that are damaging lungs function or structure. By chronic pulmonary heart are not considered those hypertrophies of right ventricle which are consequences of left cardiopaths or congenital heart anomalies with skips. During the CPH evolution three stages were formed: a) uncomplicated pneumopathology, b) compensated chronic pulmonary heart and c) decompensated chronic pulmonary heart. The disorders of cardiac rhythm are often at decompensated CPH, which is proved by this scientific work as well. 40 sick people diseased of decompensated CPH are treated in purpose to establish the presence and the characteristics of cardiac arrhythmia at these patients. It is established that the major percentage of frequency is made by sinus tachycardia, atrial extrasystols, and ventricular extrasystols. Of 40 examinees 65% had sinus tachycardia, 37,5% atrial extrasystols, 30% ventricular extrasystols and 20% combined atrial and ventricular extrasystols. This proves us that there is a significant percentage of cardiac rhythm disorder frequency at the sick people of decompensated chronic pulmonary heart.

On autopsy material of fifty corpses, age 0-75 (Institute for Pathology of Medicine Faculty in Belgrade and KBC
Dragiša Mišović - Dedinje, Beograd) we have met with all kind of comlications of bronchyectazia and bronchyloectazia
which were mentioned in literature. All statement complications, which caused death, we classified into lung and out lung
ones. Among lung complications, we stated that pneumonia among children in a big number of cases of congenital
bronchyectazia and cystic fibrosis of lungs. The apses of lungs were represented in four cases of secular and spindle shaped bronchyectazia and in one case of distal secular bronchyectazia it was represented in empiem pleure. In two cases lung gangrene was noted. Among out lung complications we can emphasize two cases of sepses of brain Apses. Leptomeningitis was present at one case. Among long-term spread bronchyectazia and bronhyloectasis with chronically manure inflammation and lung abscesses (bronchiectasiae abscendons), we stated the deposit of amiloids in glomerulus's and blood vessel of kidney intersticium as well as in liver and spleen. Chronical lung heart (cor pulmonale chronicum) was the most often complication of bronchyectazia and bronchyloectasia in the middle and older age period of our cases and it had represented the major cause of death.

Condylomata gigantea is an expansive, destructive lesion that affects most frequently anal and perianal region, and
rarely vulvar and vaginal region. We will describe a clinical case of a 28 years old female patient with a diagnosis of Condylomata gigantea in anal and perianal region with propagation on vulva, vagina and clitoris. After we detected a wide base of condylomas in anal and perianal region, we performed a deep, multiple biopsy for discover of eventual malignancy.
Histologically, malignancy was not confirmed, but it was discovered a presence of HPV types 6 and 11. The patient was initially treated with a wide surgical excision, and then the rest of condylomas were removed using CO laser which had an 2
haemostatic function in the same time. Three months later, there was no recurrence.