Apart from great frequency of epithelian, especially preinvasive changes, some very rear diseases common for other lower parts of genital tract (cervix and vulva), are vaginal epithelian changes and especially vaginal intraepithelial neoplasia (VAIN). That's the reason why we don't usually think about this disease, which can have very serious consequences, especially in late discovering of changes in the stadium of invasive malign disease.The aim of this work was to diagnose all pathological changes on vagina: benign, premalign and malign, according to the age of female patients. Biopsy and operative material taken from 1331 female patients treated in Ginecology and Obstetrics Clinic “Narodni front” in Belgrade, were used in this study. The most diagnosed benign changes was condylomata acuminate (42%). Out of 20 cases of premalign changes, VAIN I was diagnosed in 5 cases (25%) as a slight degree of premalign changes, while VAIN II and VAIN III were diagnosed in 5 cases as a severe degree of premalign lesions. Out of 11 cases, there were 3 cases (27.27%) of invasive planocellar vagina carcinoma with histological degree G1N1. 8 cases (72.72%) were with histological degree G2N2, while there were not a single case with histological degree G3N3. Planocellar vagina carcinoma is the most common in the age of 41-50.

Identification of victims during war and post war conflicts means for The Republic of Serbia the most important professional, scientific and ethical investigation. Before the process of identification forensics do the exhumation, very important part of process of which depends successful identification. On the Kosovo and Metohija, from 2001 till 2004. forensics did exhumation in some massive graves and in many single graves. Experiences of experts proove that the process of exhumation is very important becouse in that first phase collecting of evidence through forensic investigations have made “disappeared” victims “visible”, empowered survivors, corrected the historical records, and exposed cover-ups. Through forensic investigations including the identification of all injuries on the dead bodies, we faced with the marks and circumstances which followed the death under existing conditions on Kosovo and Metohija. Forensics promotes democratization and rule of law.

Any need of a drug addict to conform to his drug dependence is eliminated by a successfully accomplished closed system of addictive behaviour and circular change of the state of his mind. His addictive behaviour represents the so- called indestructible homeostasis of a drug - addict' s family. Meeting the drug- user's needs deprives him from any desire to deal with his own personality and behaviour. Only in cases when the addictive behaviour is thwarted by requests and even aggressive behaviour of the parents and other members of the society (environment) who ask for explanation, the sense of menace and effect of projected pursuer is convincingly achieved, which can often lead to aggression.Using the GRADIR scale, the investigation has reported that drug addicts' families are not as defective in sharing their emotions as they are defective in their structure, which intensifies irregularity that leads to drug use. If family were better structured, its member might not turn to drug.

Oral isotretinoin is highly effective in treatment of patients with severe acne, but has been concerned with causing occasional depression. Clinicians should be alert to the high prevalence of depression among people with acne. Isotretinoin has many unwanted effects, among which possible unproven effects on mood have to be included. If depression or other mood change occurs, then isotretinoin treatment should be discontinued. If treatment is continued, psychiatric support should be obtained.

Inhibins are glycoprotein hormones of which there are two molecular forms, inhibin A and inhibin B. Classically, inhibin is known to have a negative feedback effect on pituitary follicle-stimulating hormone secretion. The fetoplacental unit produced inhibin throughout pregnancy. Inhibin Ais the predominant molecular form of inhibin in maternal circulation from 4 week of gestation. Although the precise biological function of inhibin Ain pregnancy is unclear, it is evident from recent studies that inhibin A could be a better marker of placental function than human chorionic gonadotropin because of its shorter half-life. The possible clinical application for the measurement of inhibin Ain early pregnancy could be in predicting miscarriage , Down's syndrome, preeclampsia and fetal growth restriction in the first and/or second trimester before the onset of yhe clinical symptoms. Inaddition, several evidences underline the potential role and the clinical usefulness of their measurements in the diagnosis, prevention,prognosis and follow-up of different gestational pathologies such as:threatened abortion, placental tumors, hypertensive disorders of pregnancy,intrautherine growth restriction,fetal hypoxia.The measurement of inhibin Aand activin Ainto the biological fluids of pregnancy will offer in the future further possibilities in early diagnosis,prediction and monitoring pregnancy diseases.

L-carnitine is assorted with non-vitamin nutritives (metavitamines) on the grounds of importance to the living process, while itb similar to aminoacids in terms of structure. It has multistructural role in functioning of an organism while one of the most important and best investigated roles is the sphere of energizing metabolism because it is needed for the transport of the longchain fatty acids into the mitochondria where they are subject to a β oxidation. It has widespread clinical application in prevention and therapy of: genetic and secondarycarnithine deficiency, cardiovascular disease, lipid metabolism disorder, carbohydrate metabolism disorder, aciduria of organic acids, renal and liver insuficiency, neuropathy, miopathy, as well as the means for improvent of fitness capacites of sportsmen. L-carnitine is crucial part of organism of mamals, therefore it can be applied in relatively big doses whereby it requires no detoxication in liver, on the contrary, it significaty increases its detoxication capacites. Key words: L-carnitine, Physiology, Prevention , Therapy. L-carnitine is assorted with non-vitamin nutritives (metavitamines) on the grounds of importance to the living process, while itb similar to aminoacids in terms of structure. It has multistructural role in functioning of an organism while one of the most important and best investigated rol condarycarnithine deficiency, cardiovascular disease, lipid metabolism disorder, carbohydrate metabolism disorder, aciduria of organic acids, renal and liver insuficiency, neuropathy, miopathy, as well as the means for improvent of fitness capacites of sportsmen. L-carnitine is crucial part of organism of mamals, therefore it can be applied in relatively big doses whereby it requires no detoxication in liver, on the contrary, it significaty increases its detoxication capacites.

Echinococcus is a zoonosis, parasitic disease, caused by echinococcus granulosus, E. multilocolaris, E. Vogeli and E. oligarthus. The most frequent at humans is a cystic form of the disease caused by E. granulosus, and rarely the alveolar one caused by E. multilocolaris seu alveolaris. It can affect all the organs and tissues. The most affected ones are: liver (70- 80%) and lungs (10-25%), while rarely, at 5% it can be found in spleen, kidneys, brain, heart, pancreas, mussels and skeleton. The only secure treatment of the primary echinococcosis is the surgical one. It should start immediately after the diagnosis is set in order to avoid complications which follow echinococcosis. Several surgical methods are used in practice for live echinococcus treatment: partial pericystectomia, total cystopericystectomia and liver resection. Aim of the work is to show the importance of the echinococcus cyst of liver and treatment methods. The patient presented in the work is Dj.G., female, register number of the disease history 355/14.05.2007., 61 years old, hospitalized at Surgical Clinic because of the surgery of echinococcus cyst on the left liver lobe. Diagnosis was set by abdomen USG, CT of the abdomen, and laboratory analyses. During the surgery, we found a big echinococcus cyst localized in the second and third segment of liver, so we did a liver resection as a bisegmetectomia with total ekstirpacija of the cyst. Postoperative flow passed normally and the patient
was on the eight postoperative day sent to further home care in a generally and locally good state.

The fractures of the tibia are mainly the fractures of the long bones. In the department of the orthopedic in Kosovska Mitrovica, 45 of patient with fracture of the lower leg had been treated with using the closed method. It had been the linear fractures in the 84% of the treated cases.The most number of the patients were treated in the hospital for 5 days. In our healing we are noticed the folowed complications in the treated patients: the major infections around the pin were in the 4% of the treated patients (2 patients),the fat embolism were in the 2% of the treated patients (1 patient),the pseudoarthrosis were in the 4% of the treated patients (2 patients). Aplication the extrafocal fixat r by Mitkovich using the closed method made possible that the fracture became stable in fast and simply way with the minnor invasion at the soft tissues and with this are made the conditions for splicing of the fractures.

The aim of this study was to identify main epidemiological risk factors for the Leptospirosis at territory of Serbia. The cross sectional study was used as epidemiological method during investigation. During period of 2000-2006. Leptospirosis affected 211 people, while 14 of them died as a consequence of this illness in Serbia. Number of patients with Leptospirosis was almost equal at the territory of Central Serbia and Vojvodina region, while at Serbian enclaves in Kosovo and Metohija there was no single case of sickness. Most of the affected patients were working people, males between 20 and 60 years old (97%) with higher risk factor for contamination with disease determined by their profession (farmers, fishermen, veterinarians. Seasonal character of illness (most of the affected in August) was caused by increased exposition to Leptospirosis in summer time (swallowing of contaminated water during swimming and diving, small wounds on skin etc)

Breast cancer is mostfreqency malignant tumor in womans, cardinal causer of death in malignant tumots with continous ascendig of incidence and mortality. Actual therapy of breast cancer is multidisclipinary to consist in surgical, irradiant, cytostatic, hormonal and imunological therapy with specific directive based in disease stage. Surgical therapy is now more effectiveness metod of therapy and base of multidisclipinary therapy. In aim of prognosis desease conclusion and risk ratio of local relapse in currency is prognostic factors. With combination a few factors derive prognostic indexes with whose can acquire more information aggainst biologic behaviour of each neoplasm.