The increased protein concentration in cerebrospinal fluid is among most prominent biochemical parameter of intensified passage of macromolecules through blood-brain barrier. It is often found in cases of meningeal inflammation, neurodegeneration, neoplastic and traumatic processes developed on brain or spinal cord structures. Protein concentration in cerebrospinal fluid is often determined, but determination of albumin concentrations as well as mathematical models utilizing albumin are more reflective to the pathologic processes on the brain and spinal cord. Our study was limited to the determination of referent values for our laboratory for cerebrospinal fluid albumin concentrations, albumin quotient, as well as albumin transudat and exudat in the function of the age of probands. The results of the study show great agreement with previously published data.

Vulva can easily be examined, therefore it could be expected that any changes that may emerge at it would be easy
to notice and treat quickly and efficiently. Despite that, the incidence of pre-malignant and malignant changes is increasing.
Many risk factors connected to the emerging of these changes have been discovered, but many explanations have become
available only when the theory of the participation of HPVin oncogenesis has been set. The goal of the study is to identify all
the pathological changes at vulva - benignant, pre-malignant and malignant, according to the age of the patients, and
therefore, both biopsy and operational material collected from 1331 patients treated at GAK “Narodni Front” Belgrade, has been used. There have been 46 diagnoses of benignant changes, of which 20 (43,48%) had been diagnosed as condylomata acuminata, a change including a HPV infection. Most of these changes have occurred at patients aged 31-40. In 17 cases of pre-malignant changes, VIN I has occurred in 2 cases (11,76%), and VIN II and VIN III as more serious pre-malignant lesions were noticed in 8 samples. In 7 cases (41,18%), VIN III was discovered to be moving into a starting invasion phase. It can be concluded that VIN is most often at patients aged over 60. Malignant vulva tumors occurred in 14 cases, 13 of those where diagnosed as invading planocellular carcinoma, and one of them was metastatic. Vulva carcinomas seem to occur most often at patients aged over 60.

Women in the age of 70 years admitted to the hospital in severe condition, 4 months after transvaginal hysterectomy. Physical examinaton revealed small bowel loops passing through the anus into the auter spaces. Previous surgery was as follows: Hysterctomia totalis vaginalis, conservatio adnexorum bill, colpoperineoplastica cum myorraphiam mm. levatores any, vaginopexia sacrospinalis sec. Nichols pp. prolapsus utery totalis am. n 4. On that occasion the anterior wall of rectosygmoid colon was damageden size 70x50 mm by that time. The lesions was neither noted nor repaired during. Postoperativne course was uneventful. After 4 mounths, during phisical strain patient felt sudden pain in abdomen, need for passing the bowels, noting the passage of the intestines through the annal appertura immediate reoperation was undertaken. Through medial infraumbilical approad small intestine was mannualy repositioned the lesion of the large intestine was managed by primary suttures Vicryl 000. Drainage of peritoneum performed. Postoperative course un univentful. Intestinal function restored. Wound healed correctly, per primam.

Alkaptonuria is one of 4 disorders originally defined as an inborn error of metabolism. The hallmark of the disease is passage of urine that becomes black when left standing. There is a familial pattern of inheritance. The defect lies in the catabolic pathway of tyrosine. The product, homogentisic acid, in deficiency of the hepatic enzyme homogentisate 1,2- dioxygenase (HGO) accumulates in the blood, but is rapidly cleared in the kidney and excreted. Upon contact with air, homogentisic acid is oxidized to form a pigmentlike polymeric material responsible for the black color of standing urine. Although homogentisic acid blood levels are kept very low through rapid kidney clearance, over time homogentisic acid is deposited in cartilage throughout the body and is converted to the pigmentlike polymer through an enzyme-mediated reaction that occurs chiefly in collagenous tissues. As the polymer accumulates within cartilage, a process that takes many years, the normally transparent tissues become slate blue, an effect ordinarily not seen until adulthood. The earliest sign of the disorder is the tendency for diapers to stain black.. but in most cases desease is hardly diagnosed before the fourth decade of life, external signs of pigment deposition, called ochronosis, begin to appear. The slate blue, gray, or black discoloration of sclerae and ear cartilage is indicative of widespread staining of the body tissues, particularly cartilage. The hips, knees, and intervertebral joints are affected most commonly and show clinical symptoms resembling rheumatoid arthritis. Because of calcifications that occur in these sites, however, the radiologic picture is more consistent with osteoarthritis.

The nature of herpes simplex virus as infective agens, which can grow in number, only in live cells, and fact that many herpes virus infections of oral tissue have atypic and asymptomatic course, makes their diagnosis more difficult and complicate from infections caused by other microorganisms. The aim of this investigation were to established cytological findings oral lesions of primary and recurrent herpes infections.

In 2008. 1402 children of 1st,3rd,5th and 7th grade of 18 elementary schools in Serbian enclave of Kosovo Pomoravlje, were examined. This are villages of municipality of Gnjilane, Vitina, Novo Brdo and Kosovska Kamenica. I general 2816 children attend the elementary school. 932 of all examined children had a deformity, every ten had kyphosis, and every 8-10 had scoliosis. Every 5th child of 1st grade and every 6th child of 3rd grade had anemia. Some kind of flat-footed (pedes pllani) had every fifth to every third child. Only every tenth child was fat. 

One of aims of health surveys is comparison helth status of residents on different territories. Comparative analysis оf health surveys in five countries: (England, USA, Ireland, Canada and Hungary) and establish opportunities for comparison health status of residents in different country. Will be doing comparative analysis of results from health surveys in five quoted country. First of all, will be doing comparison of methods and derived results. Specially, will be notice on determinants of health which are applied in surveys. Methodology which was used is, mainly, similar in all country. Its health state like a best describes residents of USA. There are most smokers among Hungarians (30,5%) and least of all among Americans (17%). There are most obeses among residents of England (23,1%) and least of all among Canadians (15%). Most Americans and Hungarians (85%) visited general practitioners in recent year. Questions about limited mobility, depression, mental health, cardiovascular diseases, diabetes, blood pressure, fisical activity, mammography, prescribe medicine, estimation quality of health care service and satisfaction with health care service there isn't in most of surveys. We can conclude that the methodology, which was used in surveys, is mainly similar. There are, obviously, variances in wording questions, respecting in determinants of health wich are exploratives in questionnaires. In order to escape these variances, one of the solution would have been using standardized questionnaires, which will be using in future surveys in all country.

Craniomandibular dysfunction are serious problem in stomatological practise from the aspect of prevention therapy and checkup. The frequency of this defect as well as its sings and symptoms were registered within randomly selected sample of examinees consisting of 70 individuals. The examinees were submitted to Fricton-Schiffman clinical function analysis wich indicated the presence of sings and symptoms of craniomandibular dysfunction. Within examined population 128 examinees had the sings and symptoms of craniomandibular dysfunction. It was determined in demographic analysis that diseased examinees were between the ages of 17 and 35 as well as that this sickness was commoner to female individuals in the ratio of 4:1. The most frequent symptoms were the following: muscles pain sensitivity to palpation (888%) lateral deformation of the lower jaw while opening the mouth (778%) and sound signals in temporomandibular joint while moving the lower jaw (77%). The highest frequency of pain sensitivity was in: m. pterigoideus lateralis m. maseter and lower insertion of m. trapesius. The most frequent sound signal was the one registered during the lateral movements of the lower jaw

Fracture of orbital floor is relatively frequenthly injuries. Fractures can appear same in war or peacefull conditions. War injuries can be bursting, and in many cases is very hard, with fracture, dislocation and defect more of orbit walls. Peacefulls injuries orbital floor appear mostly in car exident, fight, fall on face, and also in sports activity. Regarding specific anatomic structure, sensitive position and content of orbital cavity, even today exists different opinion especially by question of mechanism of originate, same as question of injury treatment.

Epileptic status is one of the most urgent conditions in medicine, whose positive outcome is directly dependent of adequate treatment. The estimation of epileptic status incidence is not available. According to population studies, the incidence varies from 16 to 18 at a sample of 100000 people. The status treatment consists of a line of procedures whose goal is to stop it in as little time as possible. Medication therapy is the basis of it, and it is needed that intravenous medications are used urgently in an adequate dose, at an adequate speed (intravenous burden dose), with an adequate symptomatic therapy and correction of eventual provocation status factors. General medications used to initially treat the status are benzodiazepines, fenitoin and fenobarbiton. Randomized studies have shown that lorazepam has pharmacokinetic advantages over diazepam and that it doesn't initiate respiratory depression as often as midazolam. Also, it is more efficient than fenitoin, and more efficient than fenobarbiton. Medication treatment is confirmed to be efficient at breaking the status at nearly all of the patients, but the final outcome depends on the initial cause. If the status cannot be ended by application of conventional doses of basic medications, then a refractory status may be discussed. It may be treated by a prolonged anesthesia using barbiturates, midazolam or lorazepam.