A combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting. Also, ticlopidine is often associated with hyperbilirubinemia and abnormal liver function test values. The purpose of this study was to evaluate the correlations between biochemical variables (serum total cholesterol levels, total bilirubin concentration, serum activities of alkaline phosphatase and alanine- ALT and aspartate- AST aminotransferases) of aspirin and ticlopidine administered alone and in combination. The experiment was conducted on white laboratory rats, type Wistar. Thirty-two rats were divided in four groups and they received one of the following treatments for three days: group I - control, saline (1 ml/kg, i.p.); group II - aspirin (50 mg/kg/day i.p.); group III - ticlopidine (125 mg/kg/day i.p.) and group IV - aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day i.p.). Biochemical variables were determined at once after taking the sample of blood. Relationship between two measured variables was determined by calculating linear correlation coefficient (r). Between total cholesterol level and AST activity in control group of rats was noticed negative and low correlation (r=-0,27); in group treated with aspirin negative, high and significant correlation (r=-0,86); in group treated with ticlopidine negative and low correlation (r=-0,24); and in group treated with aspirin+ticlopidine combination positive, high and significant correlation (r=0,79). Between other investigated variables were not noticed significant correlation in all treated groups. Based on obtained results it can be noticed that negative correlation between serum total cholesterol level and AST activity in control, aspirin and ticlopidine groups becomes positive and significant only after the treatment with aspirin+ticlopidine combination.

The process of multipotential lymphatic stem cell maturation and differentiation into immunocompetent T cells is accomplished by the expression and deletion of specific surface CD antigens. The CFU-Lstem cells enter the medulla of the thymus via a post capillary venule and then migrate to the periphery of the thymic lobule. The presence of CD2 and CD7 molecules on the cell surface indicates an early stage of differentiation. This is followed by expression of the CD1 molecule, indicating the midstage of Tcell differentiation. As maturation progresses, the cells express TCRs, CD3, CD4, and CD8 molecules. It seems that intensity of interreacion between TCR/co receptor molecule complex and self peptide/MHC complex determine the outcome of the thymocite selection process. If the lymphocyte recognizes self MHC and self or foreign antigen, it will survive the selection (positive selection); if not, death of the cell will occur. Cells that pass the positive selection test leave the cortex and enter the medulla. Here they undergo another selection process in which cells directed to selfantigen displayed by self MHC are eliminated (negative selection). Cells that survive that selection then become either cytotoxic CD8+ Tlymphocytes or helper CD4+ Tlymphocytes.

It is argued that the easy availability and widespread use of highly hazardous organophosphate compounds (OPC) is the most important reason for this high number of poisoning. In this study socio pediatrics aspects of children¢s acute intoxications OPC were investigated.Data collected included age, gender, time, rout of åxposure, place of accident, first aid before admission. Àll were do to accidental event attempted suicide cases. Acute OP poisoning is a the important cause of morbidity and mortality and represent serious condition that needs rapid diagnosis and tretman because. Therapy should be started as early as possible beginning from primary and secondary level so undesirable consequences can be avoided.

Changes in the heart and blood vessels are one of the major complications that substantially contribute to morbidity and mortality of patients with systemic diseases of connective tissue.All anatomical structures of the heart can be affected by pathological process and noted the multiple pathogenic mechanism leading to changes in pericard (thickening of leaves, calcification, pericardial outburst), atrial and ventricular arrhythmia, disorders of implementation, changes in heart failure in terms of whiskered or stenosis, myocardial ischemia and heart failure. The aim was also to test the registration of the most common heart rhythm disorder and implementation as well as changes in the ST segment and T wave of electrocardiogram of patients with systemic diseases of connective tissue. The study involved 70 patients in two groups. The first group was 50 patients with systemic disease of connective tissue, and the second control group of 20 patients with lumbal syndrome. Electrocardiographic changes were observed in 38(54,3%) respondents. Observed by groups of patients with connective tissue diseases were registered in 35 (70%) and in the control group in 3 (15%) patients with a statistically significant difference (p<0,01). Statistically significant difference was noted in the appearance of ventricular premature complex, changes in ST segment and T wave.

Posterior cortical atrophy (PCA) is a slowly progressive dementia characterized by an early onset of visual agnosia, followed by components of Balint's syndrome, Gerstmann's syndrome, and transcortical sensory aphasia. The most striking neuropsychological feature of the syndrome is the dissociation between prominent visuspatial disfunction and relatively preserved memory, personality and insight. PCA is a rare syndrome. Autopsied brains of PCA patients have shown a neuropathology of Alzheimer's disease (AD). PCA is not just AD with prominent visual deficits but a distinct clinical syndrome. Neuropsychological examination is fundamental for the diagnosis. It is very important to assess visuspatial functions. Here we present a case of slowly progressive dementia with visuspatial disturbances and apraxia but relatively preserved memory functions, personality and insight.

A characteristic hemodynamic pattern has observed in patients with right ventricular infarction, with frequently accompanies inferior left ventricular infarction or rarely occurs in isolated form. The electrocardiogram may provide the first clue that right ventricular involvement is present in the patient with inferior wall myocardial infarction. Most patients with right ventricular infarction have ST- segment elevation in lead V4R (right precordial lead in V4 position). ST segment elevation of 0,1mV or more in anyone or in combination of leads V4R, V5R, and V6R in patients with the clinical picture of acute myocardial infarction (MI) is highly sensitive and specific for the diagnosis of right ventricular MI.

Any need of a drug addict to conform to his drug dependence is eliminated by a successfully accomplished closed system of addictive behaviour and circular change of the state of his mind. His addictive behaviour represents the so- called indestructible homeostasis of a drug - addict' s family. Meeting the drug- user's needs deprives him from any desire to deal with his own personality and behaviour. Only in cases when the addictive behaviour is thwarted by requests and even aggressive behaviour of the parents and other members of the society (environment) who ask for explanation, the sense of menace and effect of projected pursuer is convincingly achieved, which can often lead to aggression.Using the GRADIR scale, the investigation has reported that drug addicts' families are not as defective in sharing their emotions as they are defective in their structure, which intensifies irregularity that leads to drug use. If family were better structured, its member might not turn to drug.

The aim of this study was registration of change in the amplitude of motor unit action potentials of m. bicepsa brachii of the dominant arm in fatigue. Investigation as coducted on 30 participants (15 male and 15 female). In the first phase of the research, 1-RM (one repetition maximum) of the dominant arm was measured. In the second phase, registration of changes in the amplitude of motor units action potentials was conducted during static contraction. Registration was performed twice, with time interval of 15 minutes. The second measurement was significantly shorter than the first. Analysis of EMNG-registration showed linear increase in MUAPamplitude in time. Significantly higher values of MUAPamplitude in the second measurements were registrated in both groups (p<0.05). Analysis of MUAPamlitude velocity change showed significantly higher values in the second measurement in males. There is no significant change in all registered values between males and females (p> 0.05).

Echinococcus is a zoonosis, parasitic disease, caused by echinococcus granulosus, E. multilocolaris, E. Vogeli and E. oligarthus. The most frequent at humans is a cystic form of the disease caused by E. granulosus, and rarely the alveolar one caused by E. multilocolaris seu alveolaris. It can affect all the organs and tissues. The most affected ones are: liver (70- 80%) and lungs (10-25%), while rarely, at 5% it can be found in spleen, kidneys, brain, heart, pancreas, mussels and skeleton. The only secure treatment of the primary echinococcosis is the surgical one. It should start immediately after the diagnosis is set in order to avoid complications which follow echinococcosis. Several surgical methods are used in practice for live echinococcus treatment: partial pericystectomia, total cystopericystectomia and liver resection. Aim of the work is to show the importance of the echinococcus cyst of liver and treatment methods. The patient presented in the work is Dj.G., female, register number of the disease history 355/14.05.2007., 61 years old, hospitalized at Surgical Clinic because of the surgery of echinococcus cyst on the left liver lobe. Diagnosis was set by abdomen USG, CT of the abdomen, and laboratory analyses. During the surgery, we found a big echinococcus cyst localized in the second and third segment of liver, so we did a liver resection as a bisegmetectomia with total ekstirpacija of the cyst. Postoperative flow passed normally and the patient
was on the eight postoperative day sent to further home care in a generally and locally good state.

An anonymous poll was conducted, targeting medics in health institutions in the area of Novi Sad, Bačka Palanka, Bač, Temerin and Odžak (south Bačka region). Doctors involved in this survey are representative sample of the total population. Aim of the survey was to analyse drugs prescription and use in modern medicine, as well as to determine the extent of compliance of general medicine doctors with modern pharmacotherapy requirements. Results show that more than a half of doctors feel that the positive list corresponds to real needs, and that the price of medicaments and participation is low. Also, they believe that the drug consumption exceeds real needs. The high percent of medics does not have sufficient knowledge of the modern pharmacotherapy attitude towards the certain drugs use, which demonstrates the lack of continuing education in the field.