Patients with epilepsy more often than healthy individual have cognitive disorders, what may be the result of different factors, among which significant place occupy the treatment with antiepileptic drugs. Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of our study is to clarify the role of depression in developing cognitive adverse events during therapy with topiramate in patients with refractory epilepsy. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatement took place on the Institute of neurology Clinical center of Serbia. All patients are neuropsychological tested twice. First time before the start of therapy with topiramate on basic antiepileptic therapy, and next time two months after the achieving of stable dose of 200mg/day. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. For estimate degree of depression we used Hamilton's scale of depression. Patients with the depressive manifestation had lower scores on cognitive tests in comparition to patients without the depression, before and after introductions topiramate. More the score of depression was larger, the scores of neuropsychological tests have been worse. Depression has bad influence on the cognitive functioning and her presence in the patients with epilepsy increases the risk from development of cognitive adverse events of topiramate.

The objectiv of this study were to evaluate the applicability of the methods of Tanaka and Johnston predictions to our population.60 dental study casts(30 male and 30 female patients)were used.The measured sum of the width of the permanent canine and premolars were compare with values obtained from Tanaka-Johnston formula.The method of Tanaka-Johnston were tended to exaggerate the actual sum of the lower permanent canine and premolars for male and female samples,with statistically significant differences.

Total happening «en masse» is important to epidemiologist - and so it is «massive manifestation of natural system of the sickness» (PSB). Manifestation "en masse" of the natural system of parotitis N makes quantities of qualities N , N , B b N , N , N etc. a) «Causative connection» (UV) is the reason of sickness appearance. UV has its own causes of appearance, Z neB z and so the hierarchy of cause in the complex happening from subsystem. Nongenotopic or/and entropic causes of appearance of causative bonds (connections) as equilibrium connects and/or separates binary elements of causative bond  (connection). Pathogenic of contagium exists virtually in happening «en masse» in pre pathogenesis, prior to forming «immanent UV». b) Realising conjunction between the subsystems makes appearance of «immanent causative connection». That is a moment from which comes to obligatory demonstration of pathogenic as inner cause of contagium and consequent getting sick. The author concludes that «natural work» is the cause by which UV appears. Natural work is outer cause of massiveness. Just by appearance of "immanent UV" the showing of contagium pathogenic in the subsystem of sickness. The pathogenic of contagium can be proved by artificial experiment and that way the Henle-Koch postulates can be satisfied, It happens that way that input disturbance unable to be shown. Finally, anyway natural happening should pass judgement on authenticity of the theory on natural happening. 

Family planning is a civilizational value that should lead to a reduction of abortions, especially abortion as a method of family planning. Contraception or pregnancy prevention is the most purposeful way of birth control. It includes all the means and methods to a certain point, and certainly before the implantation of blastocyst, they stop the natural process of reproduction. The aim of our study is to analyze the application of some method of contraception among women who had and who had an early abortion in the sample and to analyze the application of some method of contraception in the study group of women and their correlation with the attendance of education in counseling contraceptive after intentional interruption of early pregnancy. A significant change in the use of contraceptive after pregnancy termination, and conducted training in family planning, is that the increased incidence of permanent contraceptive methods, compared to their occasional use.

Cervix cancer is the second most frequently found cancer in women, after breast cancer and represent one of the biggest problems of modern medicine. The aim of treatment is to determine the frequency of certain premalignant and malignant changes in cervix and the method of its operative treatment. By a retrospective method, 360 women have been operated due to the changes in cervix from 1999-2008 at Obstetrics &Gynecology Clinic of Clinical Center of Montenegro. Out of this number the total of 297 women with premalignant lesions of cervix was found and 63 women at an operable stage of cancer. With premalignant cervix changes the most frequent indication for operation was CIN III - 24.57% of patients. Cervix conization -80.13% is most frequently used as an operable intervention with premalignant changes in cervix. The groups of 40-49 years of age and 50-59 years of age are the ages of patients with most frequently conization done. The most frequent indication to operate malignant cervix was Ca I b. Wertheim-Meigs radical hysterectomy was performed with all patients with operable malignant changes. With an early identification, an adequate evaluation, the treatment, constant and cautious monitoring, almost any cervical intraepithelial neoplasia can be cured. Without the treatment, 30-50% of cervical dysplasia can advance into and invasive cervix cancer. 

Acute viral hepatitis A (HAV) is a benign self-limited disease, which does not become chronical and does not require obligatory hospitalization. It's an intestinal infectious disease with a dominantly fecal-oral way of transmission. Endemic epidemic appearance of this disease on the municipality of Prijedor, with a very high level of incidence, from the sixties of the 20-th century, has put the viral hepatitis among the priority problems of epidemiologic practice. During the period 1965-2007. in Prijedor there were 5707 registered cases of HAV contaminated people and three death cases. From 1990 it has been noticed an epidemiologic regression of HAV followed by its complete absence during the period 1997-2007. Studies of reasons of HAV regression have been conducted by a descriptive-epidemiologic method according to sex, age, ethnic affiliation, place of residence, seasonal appearance of disease, and the way of water supply. It has been determined that there is no statistically important differences among contaminated people according to sex, differences in other treated parameters correspond to the data from literature [1,2]. Seroconversion has been proved in 53 persons or 55,2% of tested people. Percentage of sero-positive people was 93,7% among people older than 60 years of age and 79,2% among the refugee population. Based on studies, the epidemiologic regression of HAV from the 90-ties of the 20th century, is explained by the fact that this disease appears in the interepidemic period, that there is a significant collective immunity of population with the HA virus, and the most important, the basic epidemiologic factors which contribute to the spreading of disease have been removed - the majority of population live in the urban and suburban areas where a hygienic water supply has been provided for. Also the customs and habits of population have been significantly changed. 

Rheumatoid arthritis is a complex disease, which produces articular symptoms and damage, leading to disability. The aim of the study was the estimate frequency comorbidity, functional ability of patients with rheumatoid arthritis.This study included 60 patients (48 female and 12 male) with rheumatoid arthritis, mean age 53,92±7,06. Anatomical stage and functional class were analyzed according to Steinbrocker`s criteria. Functional disability was perfo-rmed using health assessment questionnaire (HAQ) score. Comorbidity was observed in 36 (60%) of patients (33 female and 3 male). Hypertension were found in 19 (31,67%) of patients, whereas 8 (13,33%) of patients had diabetes. It was established that 7(11,67%) of patients suffered osteoarthritis. The median HAQ score was 1,25±0,70. Poorer functional status was observed in 40% of the patients with comorbidity (HAQ score ≥2), than in the group of patients without comorbidity (21,67 %). The results of the study are showing large frequency coexisting disease in patients with rheumatoid arthritis. The frequency of hypertension and diabetes was greater comparing to general population. The patients with rheumatoid arthritis show harder anatomical stage and comorbidity and greater functional disability, as compared to the patients without coexisting disease.

Prostatic intraepithelial neoplasia (PIN) is putative premalignant lesions of the prostate. This lesion has role as precuror of prostatic carcinoma (PC), predictive role for PC and high coexistens with PC. Existed two grade of PIN: low grade PIN (LGPIN) and high grade PIN (HGPIN). PC is most important malignacy in man and has high mortality in male. The aim of research was to invastigated morphological comparative patterns of HGPIN and PC. We analyzed biopsy material of 299 cases (cs). We used histopathological metods of investigation. We found HGPIN in 42 cs (14.0%) with mean age 66.3 y and PC in 35 cs (11.7%) with mean age 70.7 y. HGPIN was most frequently in the seventh decade of life (54.8%), and PC in the eight decade (45.4%). Four common pattern of HGPIN were identified: tufting (78.6%), micropapillary (72.8%), cribriform (16.6%) and flat (9.5%). In 21 from 35 cs (60%) with PC was coexistent HGPIN. HGPIN we found in the periferial part in the 22 cs. (52.4%) and in the periurthral part of the prostate in the 12 Cs. (28.6%). HGPIN were multicentric in the 22 cs. (52.4%), in the 15 cs. (68.2%) in the periferial part, and in the 7 cs (31.8%) in the periurethral part of the prostate. PC in the 22 cs (62.9%) was localized in the periferial, and in the 7 cs in the periuretral portion of the prostate. PC was multicentric in 28.6%. Important histological patterns for distinction HGPIN i PC are: disruption of basal cell layer, perineural invasion, mitotic figures, multiple nucleoli, collagenous micronodules, infiltrative growth. HGPIN and PC we found in sufficient percentage. Both lesion were most frequently multicentric, periferial localisation and coexistent. Because of that these lesions needed serious clinical and histological investigations for patients.

The Early Warning Score is a simple physiological scoring system that can be calculated at the patient's bedside, using parameters which are mesured in the majority of unwell patients. Patients suffering in-hospital cardiac arrest often have abnormal clinical observations documented prior to the arrest. Study objestives:This study assesses wheather these patients have less favourable outcome following in-hospital cardiac arrest. Matherials and the methods:For the present study, the patients' hospital charts were reviewed to identify possible abnormal observations within 8 h prior to the arrest. Results: From the total of 100 patients who sufferd in-hospital cardiac arrest, 64 patients had documentation of vital signs and 9 patients had no documentation of vital signs. Of the patients with documented vital signs 27 (29,7%) had normal vital signs and 64 (70,3%) had abnormal observations. Among these 64 patients the distribution was as follows: 17 patients (13,1%) had respiatory rate below 8 or over 20 per min, 40 (30,8%) had puls rate below 40 or over 140 beats per min, 20 patients (15,4%) had systolic arterial blood pressure below 90 or over 200 mmHg, 5 (3,7%) had temperature (˚C) below 36,1 or over 37,9 ˚C, 20 (15,4%) had oxygen saturation below 90%, 14 (10,8%) had decrease in consciousness and 14 (10,8%) had urine output below 50 ml/2hours). Compared with patients whose EWS were 0-2 (ОR 1,2; 95% CI: 0,935-1,507) patients with EWS 3 or more were 6,5 times more likely to die in first 24 hours (OR: 7,8; 95% CI: 1,205-50,205). Conclusions:Patients with documented clinically abnormal observations prior to in-hospital cardiac arrest have a worse outcome than those without. The main implication of these is that these patients need to be identified in time thereby possibly avoiding arrest. This can also be used when assessing the prognosis of in-hospital patients after achieved ROSC.

The authors in this work presented the case of itterative Caesarean Section. In this intervention they had a complication of endotracheal anaesthetic. Although general anaesthetic, according report the most authors, generally appliance anaesthetic during Caesarean Section, this anaesthetic have a certain failure. This are: difficult intubation, intubation in oesophagus, insufficient relaxation on myometrium, risk of depression - foetal’s central nervous system, unadequate reaction on drugs etc. Some authors have a pioritydaju of regional method according safety. Because of that all we believe, that heed is necessary in work and everybody obstetrician must conscious of this risk, like as application generally anaesthetic such as and regional anaesthetic by woman who has just given birth. In this effect we suggest that knowledge and experience of anaesthesiologies are very important.