Malignant tumors of the skin (MTS) are between the most common malignant tumors at human population. Because of their similarities, and more important, their dissimilarities, it is very important to determinate histophologycal type, grading and staging, because they are the most important factors of therapy choise and prognosis. The aim of our work was to examine those parameters, and also to define sex, age and locations distribution, as well as the value of surgical treatment. We analysed biopsy material of Institute of pathology, Medical faculty Priština from 2004-2007. year. We found that squamocellular carcinoma (SCC) and basal cell carcinoma (BCC), and malignant melanoma (MM) were more common at older persons, about 2x more common at male, little bit younger at persons with BCC and MM than SCC. The most common location was skin face; at persons with SCC and BCC significant more common than on all other skin locations. SCC was more common below, and BCC was more common on skin face above imagine line from tragus to the same side lips corner. Average size was about 1,5 cm, and macroscopic they were ulcerous, verrucous and infitrative. Invasive SCC was diagnosed in 2/3 cases in the most early stadium. In opposite MM was diagnosed in late stadium in majority cases. Moderate inflammatory infiltrate was found in most cases of all MTS. MTS was adequate removed in the most part cases.

The existence of left ventricular hypertrophy is an independent prognostic factor for cardiovascular morbidity and mortality. Heterogenous factors lead to left myocardial hypertrophy. The most frequently factors are: arterial hypertension, valvular heart disease (aortic stenosis and insufficiency, mitral insufficiency), hypertrophic myocardiopathy, left myocardial hypertrophy after myocardial infarction... For making the diagnosis of left ventricular myocardial hypertrophy used electrocardiography („voltage“ and „repolarization“ criteria) and echocardiography. Echocardiography is the gold standard for diagnosis of left ventricular myocardial hypertrophy. Left ventricular mass was estimated by the modified formula 3 3 using measurements obtained in accordance with the Penn convention: MLK = 1,04 (LDDd+PWDd+IVSDd) - (LVDd) - 13,6 Where LDDd is diastolic left ventricular internal dimension, IVSDd is diastolic ventricular septal thickness and PWDd 2 is diastolic posterior left ventricular wall thickness in diastole. LV mass indexed by body surface area (g/m ). By Penn con2 2 vention left ventricular hypertrophy criteria were ≥134 g/m for men and ≥110 g/m for women.

Seronegative arthropathy represents group of rheumatic diseases which affects younger patients, more often male. Ocular findings are numerous such as conjunctivitis, iridocyclitis, and they are a part of extraarticular clinical manifestations. Acute anterior uveitis, as most common ocular manifestation, could be a sole or associated morbidity condition at the forme of systemic diseases.

An anonimous poll was conducted, which included pharmacists employed in state and private pharmacies from Novi Sad, Backa Palanka, Bac, Temerin and Odžaci (South Backa district). The group polled was a representative sample compared to the overall pharmacists number. The poll was conducted due to the fact that routine health statistics does not provide enough representative data on drug accessibility to patients and to try to answer how administrative limits interfere with the choice of medicaments. Obtained results suggest that the biggest problem is the lack of A list medicaments, so the patients are forced to buy medicaments in private pharmacies or even in the neighboring countries. The majority of the pharmacists polled are of the opinion that the participation in state pharmacies is low. There are no significant differences in the opinion of the pharmacists from both state and private pharmacies concerning the medicament consumption, both groups are of the opinion that we are facing excessive medicament consumption, above the real need.

By the investigation it was attempted to explain the fear in adolescents from stomatological treatment, by appraisement of fear through its two components (congnitive and motorical). Congnitive component was followed by means of question mark before first stomatologican intervention (by the standard scale of general anxiety). In the research participated 100 adolescents. On the basis of analysis of question-marks, examinees were distributed into three groups: normal, pathological and increasingly anxious. On the occasion of third stomatological intervention, the patients obtained placebo (vitamine C, half tablet, orally, 30 minutes before the initiation of stomatological interventions which were identical, i.e. the sanation of deep caries has been carried out). The motorical component (entering the dentist's office, sitting down in a dentis chair and tonning of muscles) were appraised by the method of clinical observations. All parameters were measured before all three stomatological interventions. In this study, in parameters measured by clinical observation the number of questioned people who enter and sit down voluntarily, has increased and the number of people who are showing the signs of tension and who shiver has decreased, at using of placebo therapy.

Patients with epilepsy more often than healthy individual have cognitive disorders, what may be the result of different factors, among which significant place occupy the treatment with antiepileptic drugs. Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of our study is to clarify the role of depression in developing cognitive adverse events during therapy with topiramate in patients with refractory epilepsy. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatement took place on the Institute of neurology Clinical center of Serbia. All patients are neuropsychological tested twice. First time before the start of therapy with topiramate on basic antiepileptic therapy, and next time two months after the achieving of stable dose of 200mg/day. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. For estimate degree of depression we used Hamilton's scale of depression. Patients with the depressive manifestation had lower scores on cognitive tests in comparition to patients without the depression, before and after introductions topiramate. More the score of depression was larger, the scores of neuropsychological tests have been worse. Depression has bad influence on the cognitive functioning and her presence in the patients with epilepsy increases the risk from development of cognitive adverse events of topiramate.

It is obvious that outcome of the cerebral ischemia depends on many of the metabolic reactions that accompany circulatory disturbance, and forcaming neurochemical changes on the cellular level. Cerebral ischemia accompany changes in the neurotransmitters from the group of the biogenic amines, that influence a great deal whole chain of reactions that lead 66 cell to ultimate death. This processes ease up an enables distribution of the cascade reaction in ischemia leisure. To this should be added the fact, that cerebral infarct is followed with selective disturbance on hematoencephal level for 64. monoamines. It is obvious that cerebral infarct involves changes in metabolism of the central neurotransmitters. This changes could have either short or long term consequences on the ischemic process outcome. Therefore our aim in this study was to investigate the influence of the biogenic amines, serotonin and epinephrine as possible markers in estimation of the neural damage, outcome of the ischemic cerebral stroke and clinical presentation throughout correlation in changes of their concentration in liquor. Investigation included 40 patients on hospital treatment on Neurology Clinic of the CHC Pristina. During the follow up study, we estimated changes in concentration levels of the serotonin and epinephrine in liquor throughout different time intervals, correlating to the neurology status, encountering neuroradiology methods CT and MRof the brain, as a criteria in diagnosing acute ischemic cerebral stroke.

Periodontal diseases appear at the earliest age, they are progressive, long-lasting and if not treated lead to the loss of teeth in adults. By examining and identifying the frequency, range and severity of periodontium diseases, it is possible to evaluate the need for prevention and treatment of those affected with gingivitis and periodontophaty.The aim of the study is to determine the oral hygiene and periodontium status of the examined children in urban and rural areas. A total of 240 schoolchildren was examined. Significant presence of soft deposits was found in the examined children aged 12 and 15 years, disregarding the place of residence (IMN- 1.53 in town and IMN- 1.40 in the village). Calculus index values are significantly lower in the rural compared to the urban area for about 40% (0.26 in rural compared to 0.44 in urban area In relation to the place of residence (town-village), the status of the periodontium evaluated by CPTIN Index, shows that only 14.6% of the examined children need no treatment. Within the necessary treatment, 32.9% of the examinees need training in oral hygiene and 40.8% of them need removal of soft and hard deposits. Considering the recorded values from these two typical areas, it can be concluded that dental protection in these two regions has no significant influence on oral health. Thus, it is necessary to plan and conduct permanent prevention, early diagnosis and timely therapy.

The objectiv of this study were to evaluate the applicability of the methods of Tanaka and Johnston predictions to our population.60 dental study casts(30 male and 30 female patients)were used.The measured sum of the width of the permanent canine and premolars were compare with values obtained from Tanaka-Johnston formula.The method of Tanaka-Johnston were tended to exaggerate the actual sum of the lower permanent canine and premolars for male and female samples,with statistically significant differences.

Serious metabolic diseases and infections, such as sepsis, may lead to the occurrence of stress ulcers. Unfortunately, in our hospitals, the stress ulcer is often diagnosed as a separate disease, not as the manifestation of the existing stress status of the patient. Therefore, the goal of this pilot study was to establish the incidence of stress ulcers in sepsis patients treated at the Infective Disease Clinic. Patients treated at the Military Medical Academy Infective Disease Clinic during 4 month period, who experienced acute bleeding, verified gastroscopically, were subjected to retrospective analysis. Five out of 344 hospitalized patients had serious hemorrhages. Out of a total of 21 patients diagnosed with bacterial sepsis, acute gastric bleeding was verified gastroscopically in three, or 14.28 percent. To obtain more data, prospective long-term study, wich would include greater number of septic patients, should be conducted.