One of leading causes of death in the world is stroke, more often it strikes population under the age of 65, and those who survive it are left with a maximum degree of invalidity. Supratentorial infarcts are the most common form of ACM, occuring as a consequence of blood vessel occlusion, which irrigation zone is above tentorium, and it appears in 80% of infarcts. Diagnosing of such infarcts is based on clinical and neuroradiological parameters, and computed tomografy is called "gold standard". Therefor, our goal was to introduce a CT parameters, which follow complications of supratentorial infarcts and have predictional character. A prospective study followed the state of 60 patients with supratentorial infarcts of brain, performed CT diagnostics, established infarct complication parameters and their effects on clinical state and diseases outcome. Large tentorial infarcts in ACM vascularisation zone, mass-effects and mediosagital structure motions are significant predictors of infarct ill outcome when it comes to surviving and functional recovery. 

Tumor budding refers to an isolated cell or a cluster of up to five undifferentiated tumor cells, located in the stroma close to the invasion frontline of a carcinoma. It has been observed that tumor budding invariably precedes both an invasion into the lymphatic vessels surrounding a tumor and the development of metastases in lymphatic nodes. The aim of this paper is to determine the link between tumour budding, lymphatic vessel invasion and presence o lymph node metastasis in colorectal carcinomas. The study involved 92 cases of colon and upper rectum cancers removed at the Trebinje General Hospital and the Medical Centre in Kosovska Mitrovica. High-grade tumour budding was diagnosed in 66 (71.7%) cases, and lowgrade tumour budding in 26 (20.3%) cases. Lymphatic invasion was detected in 63 (68.5%) cases (55 (87.3%) of these cancers showed high-grade tumour budding, while on the other hand 8 (12.7%) had low-grade tumour budding). Lymphonodal metastases were found in 45 (48.9%) cases (of which 36 (80.0%) were high-grade and 9 (20.0%) low-grade incidents). Based on the ÷2-test, it may be concluded that the distribution of tumour budding in relation to lymphatic invasion (p<0.001) is statistically very significant, which was not confirmed in the case of metastases developing in lymphatic nodes (p>0.05). In conclusion, tumour budding is highly linked to lymphatic invasion, which it most probably precedes. 

The objective of this study that included 34 patients with psoriasis was to assess the reliability of the disease severity measures (i.e. Psoriasis Area and Severity Index - PASI) and the reliability of the health related quality of life measures (i.e. EuroQol EQ-5D Quality of Life Scale - EQ-5D, Dermatology Life Quality Index - DLQI and Psoriasis Disability Index -PDI). High interobserver correlation reliability and good test-retest reliability of PASI scores, as well as good test-retest reliability of EQ-5D, DLQI and PDI scores were achieved. Correlation coefficients between the test and retest scores on DLQI and PDI were higher than those on the dimensions and on EQ-VAS in EQ-5D. Disease severity scores given by PASI and the quality of lify scores given by EQ-5D, DLQI and PDI offered the reliable assessment of both the psoriasis severity and the quality of life of the people with psoriasis.

Cominution of bone fragments and weakness of soft tissues dominate in cominuted fractures of ancle joint. This conditions representing big problem for proper osteofixation. Authors demonstrated external fixation tip Mitkoviæ for operative treatment of cominuted fractures of ancle in two patients. In both cases they achieved excellent functional outcome (by AOFAS score). This method distinguish easily aplication, stability of bone fragments, good biodynamic conditions. Those caracteristics provide optimal conditions for bone healing and authors recomended this method for treatment cominuted fratures of ancle.

Introduction: Upon teeth are lost, morphological and functional disorders are caused on stomatognathic system. Since a longer period of time, total dentures made on conventional way were the best choice for treating toothless patients. Because of specific configuration of the toothless lower jaw, patients with total dentures mostly suffer problems with lower jaw total denture. From the time when osseointegration was applied as a successful clinical concept, implants have been used as well as for retention and stabilization of the total dentures. Case report: 66 years old male patient underwent surgery where implant-prosthetics rehabilitation of lower jaw is attained with application of four Bredent mini implants, used for retention and rehabilitation of total acrylic denture. The overall process was completed in one session within approximately one and a half hours, with the regular post surgical care and immediate load of implants. Conclusion: Taking into consideration simplicity, safety and non invasive procedure of placing mini implants, as well as their effect on improving quality of life of toothless patients, and economic aspect, we can conclude that along with classical and small implants they present future and method of choice for the rehabilitation of toothless patients.

Hydatid disease is a parasitic infestation by a tapeworm of the genus Echinococcus which represent significant healthcare problem in Montenegro as in many other regions of the earth. The incidence in Montenegro is 4.57/100.000. Communications with bile ducts is one of the most frequent complications of the hydatid disease. Wide communications can be followed with cholangitis and obstructive jaundice. We presented 51 years old patient with obstructive jaundice and hydatid cyst of the liver. Total pericystectomy is golden standard of the surgical treatment, which is, unfortunately possible only in 6-10% of the cases. The usage of the intraoperative ultrasound is standard procedure.

Bacterial meningitis is an infectious disease, with potentially fatal outcome, where the main event reflects inflammation of soft meninges and associated phenomena on the other structures of the central nervous system. Despite the use of powerful antibiotics and other drugs and therapeutical measurements, the number of diseased, as well as the mortality from this suerious disease, are not changed for years. The most common pathogens of bacterial meningitis in children age are H.influenzae, S.pneumoniae and N. meningitidis. Other significant causes are Streptococcus B, E.colli, L.monocytogenes, Salmonella, Pseudomonas and other Gram-negative bacteria. Our research included 120 children sufferin from bacterial meningitis. Out of the total number of treated children, the highest incidence was in age of infants (51,6%), and regarding to the gender structure, male were somewhat more frequent (54,6%). The most significant unfavorable factors for occurrence of sequalea were: younger age, the type of bacteria, bacterial concentration in cerebrospinal fluid, the time required for liquor sterilization, hypoglycorrhachia, focal neurological sings and convulsions. Complications could relate to the central nervous system or some other organic systems. Convulsions are the early complications of bacterial meningitis. Hearing impairment is often present with severe forms of bacterial meningitis with convulsions, prolonged febrile state and presence of hypoglycorrhachia. Epilepsy is rare, late sequelae, while hydrocephalus is more likely to occur in neonatal meningitis. Heavy neurological damage occures in 5% of the children.

We treated 15 subfertile men with varicocele with combination of subinguinal ligature of spermatic vein or plexus pampiniformis and medicaments. In a five-year period , we registered 5 pregnancies (30%) in female partners of our patients. We consider subinguinal ligature of spermatic vein as minimally invasive and cost-effective initial treatment of "infertile couples".

Introduction: Most permanent teeth erupt and establish proper occlusion. In some cases, the permanent teeth have a problem in the eruption and remain impacted in bone.There are two possibilities. 1. Extraction of impacted tooth and its replacement implant or a prosthetic replacement, 2. Surgical release of the impacted teeth and orthodontic traction in the dental arch. The time of treatment, type of surgery release impacted teeth, orthodontic techniques and possible problems during treatment, depending on the type of the impacted tooth and its location. Case report: Clinical examination 14-year-old patients concluded the lack of maxillary canine teeth in the dental arch. Panoramic image showed bilateral canine impaction in the upper jaw. The analysis of X-ray image was recorded axial and in the middle alveolar position of both the impacted tooth. This is why we chose the of closed eruption method. Discussion: Impacted maxillary canines, the middle alveolar ridge treated by closed eruption, except for a slight increase in clinical crown of the tooth does not show other changes deteriorate.

Gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract. Anatomic locations, in decreasing, are: stomach (60%), small intestine (30%), colon and rectum (5%), oesophagus (5%). Histogenesis is still unclear, criteria of malignancies are not adapted, biological behavior in not known, and the diagnosis and prognosis are questionaly. Although usually asymptomatic, large gastrointestinal stromal tumor may present with repeated bleeding. Most often diagnosis in mode during the explorative laparotomy and postoperative immunohistochemical analysis of specimen. In this paper we have analized patients with gastrointestinal stromal tumors of the oesophagus. The patient preoperatively diagnosed submucosal tumor of the esophagus presented with repeated gastrointestinal bleeding. After the resuscitation, we performed total gastrectomy. The immunohistochemical analysis proved benign GIST. Surgical resection is a treatment of choice gastrointestinal stromal tumors presented with gastrointestinal bleeding.